Research Journal of Pharmaceutical, Biological and Chemical Sciences Studies on hepatoprotective effect of hexane extract of Dillenia indica against CCl 4 induced toxicity and its safety evaluation in wistar albino rats

ABSTRACT The present study was carried out to evaluate the hepatoprotective effect and safety evaluation of hexane extract of Dillenia indica seed in wistar albino rats. The different groups of animals were administered with 30% CCl 4 (1 ml kg-1b wt) in olive oil intraperitoneally. The seed extract at the dose of 250 and 500 mg kg-1b wt were administered to the CCl 4 treated rats. The seed extract produced significant (p<0.01) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, urea, creatinine and lipid peroxidation and significantly (p<0.01) increased the level of SOD, CAT, GPx, GR, GST, GSH, Vitamin C and E and protein. Sub-acute toxicity studies showed no alteration in biochemical parameters (p<0.01) compared to control groups. DNA damage of rat WBC caused by CCl 4 injection was considerably counteracted by treatment with the extract. From the results it was suggested that seed extract possess potent hepatoprotective antioxidant properties and no toxic effects

Deaths associated with anaethesia and surgery

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Althesin (CT 1341) - A New Intravenous Anaesthetic Agent

Althesin (CT 1341), a new intravenous steroid anaesthetic agent without steroid activity, was given as induction agent to a total of 104 patients and the side-effects noted. Two dosage ranges were used and the side-effects compared. The drug was found to be a safe induction agent, but side-effects were often troublesome. It can be used as a substitute for thiopentone sodium, especially in patients who are going home the same day.S. Afr. Med. J. 47, 1 (1973)

Production of ethanol from mango (Mangifera indica L.) peel by Saccharomyces cerevisiae CFTRI101

Mango fruit processing industries generate two types of waste, including solid waste (peel and stones) and liquid waste (juice and wash water). Utilization of this waste is both a necessity and challenge. This work was aimed to investigate the suitability of dried mango peel for ethanol production. The mango peel contained good amount of reducing sugars up to 40% (w/v). Direct fermentation of mango peel extract gave only 5.13% (w/v) of ethanol. The rate of the fermentation was very slow. Nutrients such as yeast extract, peptone and wheat bran extract were tested for the supplementation of mango peel medium and it was observed that the nutrient supplementation increased the ethanol production significantly up to 7.14% (w/v). The suitability of wheat bran extract (WBE) based medium, which is cheap and  abundantly available for mango peel fermentation was also discussed.Key words: Mango peel, ethanol fermentation, nutrient supplementation, wheat bran extract