110 research outputs found

    Improving the methodological tools of market pricing in exhibition marketing

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    Purpose: The purpose of the study is to determine ways to improve the methodological pricing tools in exhibition marketing from market positions. Design/Methodology/Approach: The leading method of research is a systematic approach, which is used to substantiate the economic and mathematical model of the optimal market price of the exhibition area, which is set depending on the quality of the exhibition. In order to measure differences in the quality of exhibition events, authors proposed to use reference-exhibition benchmarking characterized by the best price / quality ratio. Findings: The results of the study form the methodological basis for improving pricing not only in the exhibition business, but also in other areas of business activity. This is possible if the goods (services) are produced in the conditions of a monopolistic competition, and the quality of an individual product (service) could be quantified in a conventional unit, which should be scientifically substantiated. Practical implications: This study is of practical value for both exhibition organizers and their participants. Using of expo-activities of the developed methodological tools of market pricing allows strengthening their competitive positions and increasing the profitability of exhibitions, if the optimal market price of the exposition calculated by the proposed method compensates the average total costs of the exhibition company. Originality/Value: The article substantiates the original conceptual approach to exhibition pricing, which is based on interaction marketing, benchmarking and extremely high price, which prevents the formation of demand from exhibitors, that is proposed to be called the alternative price. It becomes possible to provide a scientific basis for determining the optimal market price of the exhibition area, that maximizes the profit of the organizing company.peer-reviewe

    Stress and arterial hypertension: ISIAH rat strain

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    The main views of the issue of stress and hypertension are briefly reviewed. It is well known that stress is one of the major risk factors for cardiovascular disease development. Increase in blood pressure is a typical manifestation of the acute stress response. This fact is the reason to hypothesize that chronic stress causes the development of hypertensive disease. An association of hypertension with psychological stress in humans was shown in several works. In addition, it was demonstrated that hypertension was accompanied by an increase in sympathetic tone. On the other hand, there were many population studies in which no association was found between different types of chronic stress and arterial hyper­tension. Thus, the question is far from being answered. Even in the cases when one managed to obtain a signi­ficant hypertensive effect in experimental studies with emotional stress, it was difficult to explain the mechanisms mediating the formation of stressinduced hypertension. To clarify the situation, one of the authors of this review decided to begin the breeding of a rat strain with increased blood pressure response to emotional stress. This breeding gave rise to inbred rats with persistent stress-induced arterial hypertension. A brief history of the development of the genetic model ofstress-induced arterial hypertension, the ISIAH rat strain, is given. A retrospective review of the studies performed with ISIAH rats is presented. The contribution of genotype changes in the neuroendocrine systems involved in stress and blood pressure regulation to the development ofstress-dependent hypertension in the ISIAH rat strain is shown

    Nearby Doorways, Parity Doublets and Parity Mixing in Compound Nuclear States

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    We discuss the implications of a doorway state model for parity mixing in compound nuclear states. We argue that in order to explain the tendency of parity violating asymmetries measured in 233^{233}Th to have a common sign, doorways that contribute to parity mixing must be found in the same energy neighbourhood of the measured resonance. The mechanism of parity mixing in this case of nearby doorways is closely related to the intermediate structure observed in nuclear reactions in which compound states are excited. We note that in the region of interest (233^{233}Th) nuclei exhibit octupole deformations which leads to the existence of nearby parity doublets. These parity doublets are then used as doorways in a model for parity mixing. The contribution of such mechanism is estimated in a simple model.Comment: 11 pages, REVTE

    Interaction Of Law Enforcement Authorities As The Basis Of Effective Combating Economic Crime

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    The relevance of this article is due to the place of law enforcement agencies in the system of economic security of Ukraine. The purpose of the article is to conduct a scientific study on the issues of organizing interaction of law enforcement agencies to ensure economic security of Ukraine. The leading research methods are general scientific and special research methods, including methods of logic, analysis, comparison etc. The results of this study are a theoretical and practical study of the economic security sphere in Ukraine, outlining general scientific categories and identifying ways to increase the level of cooperation of law enforcement agencies in this field. The significance of the obtained results is reflected in fact that this study may serve as a basis for outlining future changes to the current legislation of Ukraine on increasing levels of cooperation of law enforcement agencies to ensure the economic security system in Ukraine

    The ART-XC telescope on board the SRG observatory

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    ART-XC (Astronomical Roentgen Telescope - X-ray Concentrator) is the hard X-ray instrument with grazing incidence imaging optics on board the Spektr-Roentgen-Gamma (SRG) observatory. The SRG observatory is the flagship astrophysical mission of the Russian Federal Space Program, which was successively launched into orbit around the second Lagrangian point (L2) of the Earth-Sun system with a Proton rocket from the Baikonur cosmodrome on 13 July 2019. The ART-XC telescope will provide the first ever true imaging all-sky survey performed with grazing incidence optics in the 4-30 keV energy band and will obtain the deepest and sharpest map of the sky in the energy range of 4-12 keV. Observations performed during the early calibration and performance verification phase as well as during the on-going all-sky survey that started on 12 Dec. 2019 have demonstrated that the in-flight characteristics of the ART-XC telescope are very close to expectations based on the results of ground calibrations. Upon completion of its 4-year all-sky survey, ART-XC is expected to detect ~5000 sources (~3000 active galactic nuclei, including heavily obscured ones, several hundred clusters of galaxies, ~1000 cataclysmic variables and other Galactic sources), and to provide a high-quality map of the Galactic background emission in the 4-12 keV energy band. ART-XC is also well suited for discovering transient X-ray sources. In this paper, we describe the telescope, results of its ground calibrations, major aspects of the mission, the in-flight performance of ART-XC and first scientific results.Comment: 19 pages, 30 figures, accepted for publication in Astronomy and Astrophysic

    Педиатрический мультисистемный воспалительный синдром, ассоциированный с новой коронавирусной инфекцией: нерешенные проблемы

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    Since March 2020, the first reports have appeared about the increasing, almost everywhere, number of children who have undergone a new coronovirus infection caused by SARS-Cov-2 with a symptom complex resembling the manifestations of Kawasaki disease. A special feature of the clinical manifestations of this syndrome, which is called “Pediatric multisystem inflammatory syndrome associated with COVID-19”, is the high incidence of life-threatening conditions caused by the sharp development of arterial hypotension against the background of cardiogenic or vasogenic shock.In St. Petersburg, since the end of November 2020, there has been a sharp surge in admissions of children to the ICU of various hospitals with the clinic of Pediatric multisystem inflammatory syndrome, who have laboratory confirmation of the transferred COVID-19.The purpose of this article is to attract the attention of doctors of various profiles, to combine efforts to study this pathology, to determine the criteria for verifying the diagnosis, optimal treatment regimens and dispensary monitoring of patients who have been ill.С марта 2020 г. появились первые сообщения о возрастающем практически повсеместно количестве детей, перенесших новую короновирусную инфекцию, вызванную SARS-Co2v, с симптомокомплексом, напоминающим проявления болезни Кавасаки. Особенностью клинических проявлений при данном синдроме, который получил название «педиатрический мультисистемный воспалительный синдром, ассоциированный с COVID-19», является высокая частота возникновения жизнеугрожающих состояний, обусловленных резким развитием артериальной гипотензии на фоне кардиогенного или вазогенношого шока.В Санкт-Петербурге с конца декабря 2020 г. наблюдается резкий всплеск поступлений в ОРИТ различных стационаров детей с клиникой педиатрического мультисистемного воспалительного синдрома, имеющих лабораторное подтверждение перенесенного COVID-19.Целью настоящей статьи является привлечение внимания врачей различного профиля для объединения усилий по изучению данной патологии, определения критериев верификации диагноза, оптимальных схем терапии и диспансерного наблюдения за переболевшими

    Differential expression of alternatively spliced transcripts related to energy metabolism in colorectal cancer

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    Medicinal plants – prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review

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    Simulating Functional Safety of Information Computer Systems

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    The analytical view of simulation tools for information computer systems (ICS) is presented. The concept of functional safety is introduced in terms of reliable implementation of the basic ICS functions. The research results in advanced technique for ISC functional safety simulation. This technique was practically used for three critical ICS designs

    Generalized Simulation of Functional Safety for Fault Tolerant Computing Cluster

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    Standard cluster configurations are considered usable for quality data processing. The term functional safety is introduced based on the concepts of reliability and performance in query processing. The general simulation technique is proposed for estimating functional safety of cluster. The technique is implemented in GPSS World Programming Environment, and it has provided the estimates of data processing quality in cluster
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