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Not AvailableRetrospective study on necropsy data pertaining to urolithiasis in sheep was conducted to observe the epidemiological profile in semi-arid Rajasthan. Subsequently in year 2008, a total of 27 weaner lambs comprised of 23 clinically affected with urolithiasis and 4 clinically healthy lambs were undertaken to study the mineral and haemato biochemical profile in an attempt to find out the probable cause of the menace. During the period, out of 23 diseased lambs 11 were and they subjected to post-mortem examination for confirmation of urolithiasis. The confirmed urolith cases had slightly higher Hb, PCV, TEC, RBC, WBC and epithelial casts in urine, and significantly higher serum urea creatinine, magnesium and copper compared to suspected and healthy animals. The study revealed that abnormal calcium–phosphorus ratio is predisposing the animals to urolithiasis; however; other interrelated factors needs to be explored to formulate the effective preventive measuresICAR-CSWRI Avikanaga