Variety of narrow-leaved lupine (<i>Lupinus angustifolius L.</i>) Mezenat

The purpose of the study was to create of an early ripening variety of narrow-leaved lupine with a seed and green mass yield above the standard, resistant to unfavorable biotic and abiotic environmental factors in the North-West region of the Russian Federation. As the result of many years of breeding, an early ripening variety of narrow-leaved lupine Metsenat has been developed. In a competitive varietal trial conducted in the conditions of the Leningrad Region, the seed yield of the variety Metsenat averaged 4.3 t/ha in 2015-2017 that was 1.1 t/ha higher than the standard (Kristall), the yield of green hay was 48.4 t/ha (13.9 t/ha higher than the standard). According to the results of the structural analysis of plants, the variety Metsenat was characterized by an increased number of seeds per plant (90.4 pcs.) and a good seeding of the beans (4.4 pcs.). It is a variety of universal use, with a low content of alkaloids (0.0072 %), it is technological, resistant to lodging (7 points), to cracking of beans and shedding of seeds on the vine, resistant to anthracnose (9 points). It is characterized by a rapid growth rate of plants in the initial period of vegetation. In 2018 the Metsenat variety was included into the State Register of Breeding Achievements of the Russian Federation approved for use in agricultural production in 12 regions (Patent No. 9559)

On Convergence of Solutions of Singularly Perturbed Boundary-Value Problems

A perturbation of the Poisson equation by a biharmonic operator with a small multiplier ε is considered. The asymptotic behavior of the solution of the Dirichlet problem for this equation as ε → 0 is studied. The gradient of the solution is proved to converge to the gradient of the solution to Poisson equation in L₁ (Ω) as ε → 0. The di erence of the gradients is also estimated

Stochastic effects at ripple formation processes in anisotropic systems with multiplicative noise

We study pattern formation processes in anisotropic system governed by the Kuramoto-Sivashinsky equation with multiplicative noise as a generalization of the Bradley-Harper model for ripple formation induced by ion bombardment. For both linear and nonlinear systems we study noise induced effects at ripple formation and discuss scaling behavior of the surface growth and roughness characteristics. It was found that the secondary parameters of the ion beam (beam profile and variations of an incidence angle) can crucially change the topology of patterns and the corresponding dynamics

Investigation of oxidation process of mechanically activated ultrafine iron powders

The oxidation of mechanically activated ultrafine iron powders was studied using X-ray powder diffraction and thermogravimetric analyzes. The powders with average particles size of 100 nm were made by the electric explosion of wire, and were subjected to mechanical activation in planetary ball mill for 15 and 40 minutes. It was shown that a certain amount of FeO phase is formed during mechanical activation of ultrafine iron powders. According to thermogravimetric analysis, the oxidation process of non-milled ultrafine iron powders is a complex process and occurs in three stages. The preliminary mechanical activation of powders considerably changes the nature of the iron powders oxidation, leads to increasing in the temperature of oxidation onset and shifts the reaction to higher temperatures. For the milled powders, the oxidation is more simple process and occurs in a single step

Improving Diagnostic and Eliminating Techniques of Bovine Leukemia in the Russian Federation

Leukemia occupies a leading place in the structure of infectious diseases of cattle, as it causes significant economic damage to livestock and poses a serious social danger. The dynamics of infection with the bovine leukemia virus (LV) have been studied in the Krasnodar Territory for ten years. A decrease in the level of infection of animals with the bovine leukemia virus was noted at livestock enterprises in the public sector and in breeding farms. In the individual sector, due to an imperfect animal insurance system, farmers try to keep IDT+ animals on their farms. Some progress in reducing the infection of cattle with the leukemia virus in the Krasnodar Territory has been achieved through a whole range of measures. This includes the publication of relevant regulations governing the solution of this problem by the state and regional authorities, the coordination of recreational activities by scientists of the Russian Academy of Sciences and employees of the Department of Veterinary Medicine, propaganda work among the population and heads of livestock enterprises, and the introduction by veterinary specialists of modern methods of the early diagnosis of bovine leukemia virus. The order of the Ministry of Agriculture No. 156 dated 03/24/2021 became a timely document to reduce the time of the recovery of cattle from leukemia in Russia. It significantly tightens the requirements to the terms of recovery, regulates the introduction of new methods of the early diagnosis of leukemia. As a part of the implementation of the research topic, the authors proposed a new diagnostic kit for the detection of bovine LV provirus in finished dairy products, which makes it possible to accelerate the identification of infected animals in farms that supply products to dairy plants, and in general, accelerates the elimination of leukemia in Russia

Signs and symptoms of the musculoskeletal and connective tissue system disorders

Lecture in internal medicine propaedeutic

Signs and symptoms of endocrine organs. Diseases and metabolic disorders (accents on thyroid gland and pancreas).

Lecture in internal medicine propaedeutic

Recent achievements in CAR-T cell immunotherapy for glioblastoma treatment

Glioblastoma remains the most common and aggressive primary brain tumor today. Because of the neuroanatomical location of glioblastoma, conventional chemotherapy and radiation therapy have limited efficacy in patients with these tumors. Over the past decade, antitumor immunotherapy has become widespread among modern therapeutic approaches. The importance of immunotherapeutic methods lies in their ability to increase the effectiveness of cancer treatment and prevent relapses by enhancing the systemic and local immune response against tumor cells.One of the most promising directions in modern immunotherapy is CAR-T therapy, or adoptive cell therapy using genetically modified T-lymphocytes. The functional advantage of CAR-T therapy is its ability to genetically modify lymphocytes, leading to their activation in vitro.This review examines the key principles of CAR-T therapy and analyzes the published results of clinical trials for the treatment of glioblastoma using several modifications of CAR-T cells

Dynamics and structure of disability in the Sverdlovsk region and the Russian Federation

The aim of the study – to analysis of the dynamics of disability rates in adults and children for the period from 2011 to 2020 and the structure of primary disability in the Sverdlovsk region and the Russian Federation.Цель исследования – анализ динамики показателей инвалидности у взрослых и детей за период с 2011 по 2020 годы и структуры первичной инвалидности в Свердловской области и Российской Федерации