Applying the depreciated replacement cost method when assessing the market value of public property lacking comparables and income data

The growing interest in the enhancement, management, and sale of public building stock has increased the importance of their valuation and, as a result, the need to identify suitable methods for estimating value that take into account their peculiarities. They often boast architectural features (interfloor distance, layout, finishings, types of wiring/heating systems, etc.) that make them ‘extraordinary’ assets; in some cases, these features also endow them with monumental and/or historical importance. Thus, when valuating, it is necessary to adopt suitable methods. Where comparable examples or income-based parameters specifically concerning buildings with special features are lacking, the Depreciated Replacement Cost (DRC) method is the only system that can be used to estimate their market value. This paper aims to show how the DRC method can be applied in this specific market. The theoretical part will be coupled with a practical section where the DRC method will be used to estimate the market value of an extraordinary landmark building in Rome (Italy), the Palazzo degli Archivi di Stato (the State Archives building), in the EUR district, sold by EUR S.p.A. group (formerly known as Ente EUR) in 2015

Applying the depreciated replacement cost method when assessing the market value of public property lacking comparables and income data

The growing interest in the enhancement, management, and sale of public building stock has increased the importance of their valuation and, as a result, the need to identify suitable methods for estimating value that take into account their peculiarities. They often boast architectural features (interfloor distance, layout, finishings, types of wiring/heating systems, etc.) that make them ‘extraordinary’ assets; in some cases, these features also endow them with monumental and/or historical importance. Thus, when valuating, it is necessary to adopt suitable methods. Where comparable examples or income-based parameters specifically concerning buildings with special features are lacking, the Depreciated Replacement Cost (DRC) method is the only system that can be used to estimate their market value. This paper aims to show how the DRC method can be applied in this specific market. The theoretical part will be coupled with a practical section where the DRC method will be used to estimate the market value of an extraordinary landmark building in Rome (Italy), the Palazzo degli Archivi di Stato (the State Archives building), in the EUR district, sold by EUR S.p.A. group (formerly known as Ente EUR) in 2015

Changes in Plasma Sex Steroids in Females of Two Sympatric Leptodactylus from Subtropical South America

Leptodactylus ocellatus is a well-known neotropical anuran in Argentina and Brazil, typically inhabiting marshes and streams, from sea level to 1000-1200 m in the Pampean mountains. Leptodactylus ocellatus is sympatric with L. chaquensis in Paraguay and on the Parana borders. Previous work (Cei, 1948,1949,1950,1980; Cei et al., 1955) with these two sibling species, L. ocellatus and L. chaquensis, revealed diversity in their reproductive cycles. Leptodactylus ocellatus exhibits less gametogenetic discontinuity and variety of secondary sex characters; the annual ovarian cycle of L. chaquensis, involves a fallwinter period of atresia for the residual mature oocytes from the former cycle, and at the same time a progressive auxocytic activity. The spring-summer period of mating and egg-laying of L. chaquensis is followed by resorption of retained oocytes. Moreover, in both sexes, a striking seasonal rhythm in the development of secondary sex characters has been found, together with dramatic growth of skeletal humeri and significant variation in serum calcium values (Cohen 1962a, b, 1963).Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Changes in Plasma Sex Steroids in Females of Two Sympatric Leptodactylus from Subtropical South America

Leptodactylus ocellatus is a well-known neotropical anuran in Argentina and Brazil, typically inhabiting marshes and streams, from sea level to 1000-1200 m in the Pampean mountains. Leptodactylus ocellatus is sympatric with L. chaquensis in Paraguay and on the Parana borders. Previous work (Cei, 1948,1949,1950,1980; Cei et al., 1955) with these two sibling species, L. ocellatus and L. chaquensis, revealed diversity in their reproductive cycles. Leptodactylus ocellatus exhibits less gametogenetic discontinuity and variety of secondary sex characters; the annual ovarian cycle of L. chaquensis, involves a fallwinter period of atresia for the residual mature oocytes from the former cycle, and at the same time a progressive auxocytic activity. The spring-summer period of mating and egg-laying of L. chaquensis is followed by resorption of retained oocytes. Moreover, in both sexes, a striking seasonal rhythm in the development of secondary sex characters has been found, together with dramatic growth of skeletal humeri and significant variation in serum calcium values (Cohen 1962a, b, 1963).Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Changes in Plasma Sex Steroids in Females of Two Sympatric Leptodactylus from Subtropical South America

Leptodactylus ocellatus is a well-known neotropical anuran in Argentina and Brazil, typically inhabiting marshes and streams, from sea level to 1000-1200 m in the Pampean mountains. Leptodactylus ocellatus is sympatric with L. chaquensis in Paraguay and on the Parana borders. Previous work (Cei, 1948,1949,1950,1980; Cei et al., 1955) with these two sibling species, L. ocellatus and L. chaquensis, revealed diversity in their reproductive cycles. Leptodactylus ocellatus exhibits less gametogenetic discontinuity and variety of secondary sex characters; the annual ovarian cycle of L. chaquensis, involves a fallwinter period of atresia for the residual mature oocytes from the former cycle, and at the same time a progressive auxocytic activity. The spring-summer period of mating and egg-laying of L. chaquensis is followed by resorption of retained oocytes. Moreover, in both sexes, a striking seasonal rhythm in the development of secondary sex characters has been found, together with dramatic growth of skeletal humeri and significant variation in serum calcium values (Cohen 1962a, b, 1963).Material digitalizado en SEDICI gracias a la colaboración del Dr. Jorge Williams (FCNM-UNLP).Facultad de Ciencias Naturales y Muse

Produção de base ecológica e agroecologia na percepção de estudantes de Ciências Agrárias da Universidade Federal de Santa Maria (UFSM)

O artigo analisa as percepções de estudantes de graduação do Centro de Ciências Rurais da Universidade Federal de Santa Maria (UFSM) referentes á Agroecologia e técnicas de produção sustentável. Pressupondo que Agroecologia e técnicas correlatas fazem parte de complexo sistema de estudos e práticas, em um novo paradigma científico e produtivo, não há consenso quanto aos conteúdos. Para verificar o nível de entendimento dos temas por parte de estudantes de ensino superior, foi realizado um questionário com amostra da população universitária da UFSM, tratando questões particulares, de entendimento dos temas, e da abordagem em aula. Observa-se alto nível de interesse para com as temáticas. Entretanto, os dados mostram dúvidas em relação aos conteúdos e insatisfação quanto ao modo e frequência como são tratados em aula. O fator ambiental predominou no entendimento do paradigma e a Agroecologia é abordada como conjunto de práticas, não sendo considerada, pela maioria, como ciência.The article analyzes the perceptions of Rural Sciences Center undergraduate students, of the Federal University of Santa Maria (UFSM), regarding Agroecology and sustainable production techniques. Assuming Agroecology and related technics as part of complex studies and a practical system in a new scientific and productive paradigm, no consensus was found in contents. To check the understanding level of the issues by undergraduate students, it was done a questionnaire applied to a sample of the UFSM university population addressing personal, understanding of the issues, and approach in class questions. It is observed high level of interest related to the main issue. However, the data showed doubts about the content and no satisfaction regarding the manner and frequency these subjects are handled in class. The environmental aspect prevailed regarding to the paradigm’s understanding and, Agroecology was addressed as practices set, it was not considered for most a science.Eje A5: Sistemas de conocimientoFacultad de Ciencias Agrarias y Forestale

Produção de base ecológica e agroecologia na percepção de estudantes de Ciências Agrárias da Universidade Federal de Santa Maria (UFSM)

O artigo analisa as percepções de estudantes de graduação do Centro de Ciências Rurais da Universidade Federal de Santa Maria (UFSM) referentes á Agroecologia e técnicas de produção sustentável. Pressupondo que Agroecologia e técnicas correlatas fazem parte de complexo sistema de estudos e práticas, em um novo paradigma científico e produtivo, não há consenso quanto aos conteúdos. Para verificar o nível de entendimento dos temas por parte de estudantes de ensino superior, foi realizado um questionário com amostra da população universitária da UFSM, tratando questões particulares, de entendimento dos temas, e da abordagem em aula. Observa-se alto nível de interesse para com as temáticas. Entretanto, os dados mostram dúvidas em relação aos conteúdos e insatisfação quanto ao modo e frequência como são tratados em aula. O fator ambiental predominou no entendimento do paradigma e a Agroecologia é abordada como conjunto de práticas, não sendo considerada, pela maioria, como ciência.The article analyzes the perceptions of Rural Sciences Center undergraduate students, of the Federal University of Santa Maria (UFSM), regarding Agroecology and sustainable production techniques. Assuming Agroecology and related technics as part of complex studies and a practical system in a new scientific and productive paradigm, no consensus was found in contents. To check the understanding level of the issues by undergraduate students, it was done a questionnaire applied to a sample of the UFSM university population addressing personal, understanding of the issues, and approach in class questions. It is observed high level of interest related to the main issue. However, the data showed doubts about the content and no satisfaction regarding the manner and frequency these subjects are handled in class. The environmental aspect prevailed regarding to the paradigm’s understanding and, Agroecology was addressed as practices set, it was not considered for most a science.Eje A5: Sistemas de conocimientoFacultad de Ciencias Agrarias y Forestale

The nuclear stellar disc of the Milky Way: A dynamically cool and metal-rich component possibly formed from the central molecular zone

Context. The nuclear stellar disc (NSD) is, together with the nuclear star cluster (NSC) and the central massive black hole, one of the main components in the central parts of our Milky Way. However, until recently, only a few studies of the stellar content of the NSD have been obtained owing to extreme extinction and stellar crowding.Aims. We study the kinematics and global metallicities of the NSD based on the observations of K/M giant stars via a dedicated KMOS (VLT, ESO) spectroscopic survey.Methods. We traced radial velocities and metallicities, which were derived based on spectral indices (Na I and CO) along the NSD, and compared those with a Galactic bulge sample of APOGEE (DR16) and data from the NSC.Results. We find that the metallicity distribution function and the fraction of metal-rich and metal-poor stars in the NSD are different from the corresponding distributions and ratios of the NSC and the Galactic bulge. By tracing the velocity dispersion as a function of metallicity, we clearly see that the NSD is kinematically cool and that the velocity dispersion decreases with increasing metallicity contrary to the inner bulge sample of APOGEE (|b|< 4 degrees). Using molecular gas tracers (H2CO, CO(4-3)) of the central molecular zone (CMZ), we find an astonishing agreement between the gas rotation and the rotation of the metal-rich population. This agreement indicates that the metal-rich stars could have formed from gas in the CMZ. On the other hand, the metal-poor stars show a much slower rotation profile with signs of counter-rotation, thereby indicating that these stars have a different origin.Conclusions. Coupling kinematics with global metallicities, our results demonstrate that the NSD is chemically and kinematically distinct with respect to the inner bulge, which indicates a different formation scenario

Effect of dynamic random leaks on the monitoring accuracy of home mechanical ventilators: a bench study

BACKGROUND: So far, the accuracy of tidal volume (VT) and leak measures provided by the built-in software of commercial home ventilators has only been tested using bench linear models with fixed calibrated and continuous leaks. The objective was to assess the reliability of the estimation of tidal volume (VT) and unintentional leaks in a single tubing bench model which introduces random dynamic leaks during inspiratory or expiratory phases. METHODS: The built-in software of four commercial home ventilators and a fifth ventilator-independent ad hoc designed external software tool were tested with two levels of leaks and two different models with excess leaks (inspiration or expiration). The external software analyzed separately the inspiratory and expiratory unintentional leaks. RESULTS: In basal condition, all ventilators but one underestimated tidal volume with values ranging between -1.5 ± 3.3% to -8.7% ± 3.27%. In the model with excess of inspiratory leaks, VT was overestimated by all four commercial software tools, with values ranging from 18.27 ± 7.05% to 35.92 ± 17.7%, whereas the ventilator independent-software gave a smaller difference (3.03 ± 2.6%). Leaks were underestimated by two applications with values of -11.47 ± 6.32 and -5.9 ± 0.52 L/min. With expiratory leaks, VT was overestimated by the software of one ventilator and the ventilator-independent software and significantly underestimated by the other three, with deviations ranging from +10.94 ± 7.1 to -48 ± 23.08%. The four commercial tools tested overestimated unintentional leaks, with values between 2.19 ± 0.85 to 3.08 ± 0.43 L/min. CONCLUSIONS: In a bench model, the presence of unintentional random leaks may be a source of error in the measurement of VT and leaks provided by the software of home ventilators. Analyzing leaks during inspiration and expiration separately may reduce this source of error

Expérience du blinatumomab dans les leucémies aiguës lymphoblastiques de l’enfant et de l’adolescent dans l’interrégion Grand Ouest : une chance pour tous

INTRODUCTION: Relapsed/refractory acute lymphoblastic leukemia (ALL) in children has a pejorative prognosis and justifies to be treated by hematopoietic stem cell transplantation (HSCT). A minimal residual disease (MRD) before transplantation is a major part of prognosis. Blinatumomab, a bispecific antibody CD19/CD3, allowed to achieve a cytologic and molecular complete remission in adults with refractory B-precursor ALL. This retrospective study analyses results from a pediatric cohort treated by blinatumomab thanks to an interregional structuring consortium. PATIENTS AND METHODS: Patients between 0 and 23 years old, from the 7 centers of the french "Grand Ouest" interregional network, treated by blinatumomab for a relapsed or refractory ALL, from January 2015 to January 2018, were included. The efficiency of blinatumomab was assessed in terms of complete remission, minimal residual disease, overall survival, and tolerability of treatment. RESULTS: Thirteen of 18 patients achieved a complete remission, with negative minimal residual disease for ten of them. Fourteen patients proceeded to stem cell transplantation,. Eight out of 14 patients obtained long term remission after HSCT. As far as tolerance is concerned, no serious adverse event, neurological or psychiatric disorder, was observed. CONCLUSION: Thanks to an interregional network collaboration, all children with high risk ALL coming from the western french interregion could be treated by blinatumomab. Blinatumomab offered good hematological conditions to undergo HSCT with a good tolerability