Accelerating exhaustive pairwise metagenomic comparisons

In this manuscript, we present an optimized and parallel version of our previous work IMSAME, an exhaustive gapped aligner for the pairwise and accurate comparison of metagenomes. Parallelization strategies are applied to take advantage of modern multiprocessor architectures. In addition, sequential optimizations in CPU time and memory consumption are provided. These algorithmic and computational enhancements enable IMSAME to calculate near optimal alignments which are used to directly assess similarity between metagenomes without requiring reference databases. We show that the overall efficiency of the parallel implementation is superior to 80% while retaining scalability as the number of parallel cores used increases. Moreover, we also show thats equential optimizations yield up to 8x speedup for scenarios with larger data.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

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This project is a 15 to 20 minute short film giving visibility on the reality of how success is measured in the digital world of social media and the consequences of not being able to translate one\u27s online career success to their offline life. The proponents ensured that everything in the production phase progressed smoothly, from holding online script reading and acting workshops to providing all necessary equipment to the talent on set. On the first production day, the team was in constant contact with the talent throughout the equipment set-up process and in between takes to guide him. On his second shooting day, the talent basically went through the same processes as his first day. However, the challenge he faced on his second shooting day was to create a montage of content on various social media platforms his character used in the film. This consumed more time than the team had initially planned, which is why the talent had to use the extra day they allotted for the shoot just in case of emergency. On his final day, the talent had finished shooting every sequence as well as recorded the voice-overs through a microphone which the production team had to send over to the location earlier that day. The team also assessed his needs during his stay at the shoot location occasionally to make sure that the talent had everything he needed to get through each day. Every expense made by the talent, including his transportation/gas fees, was fully reimbursed on top of his talent fee. 1080p MP4 format

Galectin-9 binds IgM-BCR to regulate B cell signaling

The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9. In resting naive cells, they show that galectin-9 mediates a close association between IgM and CD22