Enfermedad de von gierke: reporte de tres casos

La enfermedad de Von Gierke es un defecto en la glucosa 6 fosfatasa, degrada el glucógeno en el hígado, riñón e intestino. Asociada con hipoglicemia, acidosis láctica e hiperuricemia

Surface anisotropy and particle size influence on hysteresis loops in La2/3Ca1/3MnO3 nanoparticles : A simulation approach

Thermal and hysteretic magnetic properties of La2/3Ca1/3MnO3 nanoparticles were studied using Monte Carlo simulations, with emphasis on the influence of anisotropy. In this work, several nanoparticle sizes ranging from 2.32 to 11.58 nm were analyzed and their properties were compared to those of the bulk material. The magnetic behavior of the material was modeled using the three dimensional Heisenberg model with nearest neighbor interactions. Furthermore, both uniaxial and Néel anisotropies were considered for core and surface magnetic sites respectively. Deviations in the critical temperature and coercive field were observed for nanoparticles when compared with those of the bulk material. In addition to these properties, the special spin configurations that arise from the competition between the exchange, anisotropy and external magnetic field were also studied. All these effects are interpreted in terms of the surface properties such as the Néel anisotropy and the decrease in the coordination number

American College of Clinical Pharmacy White Paper: Cultural Competency in Health Care and Its Implications for Pharmacy Part 3A: Emphasis on Pharmacy Education, Curriculums, and Future Directions

Culture influences patients\u27 beliefs and behaviors toward health and illness. As the U.S. population becomes more diverse, a critical need exists for pharmacy education to incorporate patient-centered culturally sensitive health care knowledge and skills into the curriculum. Nursing was the first profession to incorporate this type of learning and training into its curriculums, followed by medicine. Pharmacy has also made great progress to revise curriculums, but inconsistency exists in depth, breadth, and methods across pharmacy colleges. This article addresses important aspects of pharmacy education such as curriculum development, incorporation of educational innovations and techniques into the teaching of patient-centered culturally sensitive health care across the curriculum from didactic to experiential learning, assessment tools, and global education. A preliminary model curriculum with objectives and examples of teaching methods is proposed. Future directions in pharmacy education, teaching and learning scholarship, postgraduate education, licensure, and continuing education are also presented

Transmisión de ondas electromagnéticas a través de cristales fotónicos periódicos y cuasiperiódicos dieléctrico –superconductor.

Con base en el método de matriz de transferencia y en el marco del modelo fenomenológico de Gorter-Casimir, se estudia la estructura de bandas fotónica y el coeficiente de transmisión de los modos TE y TM en películas delgadas superconductoras y en cristales fotónicos unidimensionales conformados por capas de materiales convencionales alternadas por capas de materiales superconductores, prestando especial atención a arreglos cuasi periódicos de dichas capas en la secuencia de Fibonacci. Al examinar el comportamiento de estas propiedades ópticas al variar la temperatura de la capa superconductora se estableció en particular que la variación de la temperatura permite modificar las frecuencias en las que ocurre la máxima transmisión de energía, así como las posiciones y los anchos de los intervalos de transmisión de energía. Se demuestra además que la cuasiperiodicidad disminuye (en todo el rango de temperaturas por debajo de la temperatura crítica) tanto el ancho de las frecuencias de transmisión como el de las brechas

Global Antifungal Profile Optimization of Chlorophenyl Derivatives against Botrytis cinerea and Colletotrichum gloeosporioides

Twenty-two aromatic derivatives bearing a chlorine atom and a different chain in the para or meta position were prepared and evaluated for their in vitro antifungal activity against the phytopathogenic fungi Botrytis cinerea and Colletotrichum gloeosporioides. The results showed that maximum inhibition of the growth of these fungi was exhibited for enantiomers S and R of 1-(40-chlorophenyl)- 2-phenylethanol (3 and 4). Furthermore, their antifungal activity showed a clear structure-activity relationship (SAR) trend confirming the importance of the benzyl hydroxyl group in the inhibitory mechanism of the compounds studied. Additionally, a multiobjective optimization study of the global antifungal profile of chlorophenyl derivatives was conducted in order to establish a rational strategy for the filtering of new fungicide candidates from combinatorial libraries. The MOOPDESIRE methodology was used for this purpose providing reliable ranking models that can be used later

El monotributo: ventajas y desventajas frente al régimen ordinario para los comerciantes informales de Buenaventura, a partir de estudio de casos.

El monotributo en todos los países latinoamericanos que lo han implementado ha sido con el objetivo de fomentar la formalización y disminuir la evasión fiscal para mejorar la calidad de vida de los comerciantes al por menor y favorecer el crecimiento económico del país; la evasión fiscal y la formalidad son las promotoras del surgimiento del monotributo, con la aplicación de este mecanismo se formalizará gran cantidad de comerciantes los cuales estará bajo la supervisión de la DIAN y al ser estos vigilados son más bajas las probabilidades de que evadan; sin embargo, este modelo no beneficia de la misma forma a todos los contribuyentes, esto depende de sus características, por esta razón se debe realizar un análisis de los beneficios que ofrece y conocer sus ventajas y desventajas frente al régimen ordinario

The Regenerative Capacity of the Zebrafish Caudal Fin Is Not Affected by Repeated Amputations

Background: The zebrafish has the capacity to regenerate many tissues and organs. The caudal fin is one of the most convenient tissues to approach experimentally due to its accessibility, simple structure and fast regeneration. In this work we investigate how the regenerative capacity is affected by recurrent fin amputations and by experimental manipulations that block regeneration. Methodology/Principal Findings: We show that consecutive repeated amputations of zebrafish caudal fin do not reduce its regeneration capacity and do not compromise any of the successive regeneration steps: wound healing, blastema formation and regenerative outgrowth. Interfering with Wnt/ß-catenin signalling using heat-shock-mediated overexpression of Dickkopf1 completely blocks fin regeneration. Notably, if these fins were re-amputated at the non-inhibitory temperature, the regenerated caudal fin reached the original length, even after several rounds of consecutive Wnt/ß-catenin signalling inhibition and re-amputation. Conclusions/Significance: We show that the caudal fin has an almost unlimited capacity to regenerate. Even after inhibition of regeneration caused by the loss of Wnt/ß-catenin signalling, a new amputation resets the regeneration capacity within the caudal fin, suggesting that blastema formation does not depend on a pool of stem/progenitor cells that require Wnt/ßcateni