The role of zeta potential in sand filtration

Issued as Final repor

Truth and the Language of War

According to modernist Friedrich Nietzsche in On Truth and Lies in an Extra-Moral Sense, language is a constructed system which fails to represent reality because of its inherent metaphorical nature. Modernist writer Virginia Woolf and postmodernist writer Tim O’Brien implicitly address Nietzsche’s belief as they warn against and represent the horrors of war in the novels Jacob’s Room and The Things They Carried. Nietzsche and Woolf develop new modernist styles, forsaking the conventions of nineteenth-century realism. O’Brien pays homage to high modernism and to Woolf in his novel through direct reference and through the modernist strategies utilized to present the unpresentable. The strongest bond between these two novels is each text’s metafictional acknowledgement that it has failed even before it has begun, echoing Nietzsche. The novels Jacob’s Room and The Things They Carried circumvent language’s limitations and make the reader feel that s/he understands war and will therefore seek peace

Biomaterial techniques to evaluate and engineer the tumor immune microenvironment in breast cancer and melanoma

Immunotherapy has emerged as the most promising new approach to increase cancer patient survival through its potential to treat both advanced disseminated disease and protect against recurrence. However, response rates in advanced melanoma and the most aggressive and deadliest type of breast cancer, triple-negative breast cancer (TNBC) are disappointingly low: only 20-40% and ~16% of patients, respectively, respond to immune checkpoint blockade (ICB) therapy. Despite immunotherapy’s potential in boosting anti-tumor immune response, tumor-induced immune suppression subverts both its development and effects. Overcoming tumor immune suppression, the mechanisms of which are still poorly understood, is thus a critical hurdle to improving the efficacy of immunotherapy in reducing the mortality associated with advanced melanoma and TNBC. Through this research, sophisticated immunological characterization approaches and engineered biomaterial techniques have been applied to preclinical tumor models to analyze and engineer the in vivo melanoma and breast tumor immune microenvironment. The central hypothesis of this work is that modeling immune suppression underlying melanoma and TNBC disease progression will reveal mechanisms of immunotherapeutic resistance to inform the development of improved immunotherapeutic strategies. The goal of this work is to utilize bioengineering approaches and techniques to manipulate and analyze immune suppressive mechanisms within the tumor microenvironment (TME) that result in disease progression. This has resulted in the following outcomes: 1) improved understanding of the tumor immune microenvironment throughout the development and progression of melanoma and TNBC; 2) novel models with which to analyze antigen (Ag) sensing and model the breast TME; and 3) insight into optimal immunotherapeutic strategies for both melanoma and TNBC.Ph.D

The Sand Filtration Of Algal Suspensions.

PhDSanitationUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/179563/2/6400866.pd