The Incidence of Low-Metallicity Lyman-Limit Systems at z~3.5: Implications for the Cold-Flow Hypothesis of Baryonic Accretion

Cold accretion is a primary growth mechanism of simulated galaxies, yet observational evidence of "cold flows" at redshifts where they should be most efficient ($z=2$-4) is scarce. In simulations, cold streams manifest as Lyman-limit absorption systems (LLSs) with low heavy-element abundances similar to those of the diffuse IGM. Here we report on an abundance survey of 17 H I-selected LLSs at $z=3.2$-4.4 which exhibit no metal absorption in SDSS spectra. Using medium-resolution spectra obtained at Magellan, we derive ionization-corrected metallicities (or limits) with a Markov-Chain Monte Carlo sampling that accounts for the large uncertainty in $N_{\rm HI}$ measurements typical of LLSs. The metal-poor LLS sample overlaps with the IGM in metallicity and is best described by a model where $71^{+13}_{-11}\%$ are drawn from the IGM chemical abundance distribution. These represent roughly half of all LLSs at these redshifts, suggesting that 28-40$\%$ of the general LLS population at $z\sim3.7$ could trace unprocessed gas. An ancillary sample of ten LLSs without any a priori metal-line selection is best fit with $48^{+14}_{-12}\%$ of metallicities drawn from the IGM. We compare these results with regions of a moving-mesh simulation; the simulation finds only half as many baryons in IGM-metallicity LLSs, and most of these lie beyond the virial radius of the nearest galaxy halo. A statistically significant fraction of all LLSs have low metallicity and therefore represent candidates for accreting gas; large-volume simulations can establish what fraction of these candidates actually lie near galaxies and the observational prospects for detecting the presumed hosts in emission.Comment: 19 pages, 17 figures; Submitted to ApJ; Corrected figure 16

The Kast Ground Based UV Spectral Survey of 79 QSOs at Redshift 2 for Lyman Alpha Forest and Metal Absorption

We present a moderate resolution (~1.15 Angstroms/pixel) survey of 79 quasars obtained using the Kast spectrograph on the Shane 3m telescope at Lick observatory. The spectra span the wavelength range of 3175-5880 Angstroms, and have typical signal to noise of 6-20 in the regions of the spectra showing Lyman alpha forest absorption. The quasars have a mean emission redshift of z=2.17, and nearly all cover the entire Lyman alpha forest between Lyman alpha and Lyman beta. Although the quasars were selected to avoid BAL, two quasars in the survey are BAL, one of which is a new discovery. We list the HI and metal ions observed in a total of 140 absorption systems. We also identify 526 emission lines, and list their observed wavelengths, along with new redshifts of the quasars. We determine the rest wavelengths of 3 emission lines or line blends in the forest to be 1070.95 +/- 1.00, 1123.13 +/- 0.51, and 1175.88 +/- 0.30 Angstroms.Comment: Submitted to the Astronomical Journa

Andromeda's Parachute: A Bright Quadruply Lensed Quasar at z=2.377

We present Keck Cosmic Web Imager spectroscopy of the four putative images of the lensed quasar candidate J014709+463037 recently discovered by Berghea et al. (2017). The data verify the source as a quadruply lensed, broad absorption-line quasar having z_S = 2.377 +/- 0.007. We detect intervening absorption in the FeII 2586, 2600, MgII 2796, 2803, and/or CIV 1548, 1550 transitions in eight foreground systems, three of which have redshifts consistent with the photometric-redshift estimate reported for the lensing galaxy (z_L ~ 0.57). By virtue of their positions on the sky, the source images probe these absorbers over transverse physical scales of ~0.3-21 kpc, permitting assessment of the variation in metal-line equivalent width W_r as a function of sight-line separation. We measure differences in W_r,2796 of <40% across all sight-line pairs subtending 7-21 kpc, suggestive of a high degree of spatial coherence for MgII-absorbing material. W_r,2600 is observed to vary by >50% over the same scales across the majority of sight-line pairs, while CIV absorption exhibits a wide range in W_r,1548 differences of ~5-80% within transverse distances less than ~3 kpc. J014709+463037 is one of only a handful of z > 2 quadruply lensed systems for which all four source images are very bright (r = 15.4-17.7 mag) and are easily separated in ground-based seeing conditions. As such, it is an ideal candidate for higher-resolution spectroscopy probing the spatial variation in the kinematic structure and physical state of intervening absorbers.Comment: Submitted to ApJL. 9 pages, 3 figures. Uses aastex61 forma

Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival

MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of cancer, including neuroblastoma, an often fatal paediatric cancer originating from precursor cells of the sympathetic nervous system. We have analyzed a set of neuroblastoma (n = 145) that is broadly representative of the genetic subtypes of this disease for miRNA expression (430 loci by stem-loop RT qPCR) and for DNA copy number alterations (array CGH) to assess miRNA involvement in disease pathogenesis. The tumors were stratified and then randomly split into a training set (n = 96) and a validation set (n = 49) for data analysis. Thirty-seven miRNAs were significantly over-or under-expressed in MYCN amplified tumors relative to MYCN single copy tumors, indicating a potential role for the MYCN transcription factor in either the direct or indirect dysregulation of these loci. In addition, we also determined that there was a highly significant correlation between miRNA expression levels and DNA copy number, indicating a role for large-scale genomic imbalances in the dysregulation of miRNA expression. In order to directly assess whether miRNA expression was predictive of clinical outcome, we used the Random Forest classifier to identify miRNAs that were most significantly associated with poor overall patient survival and developed a 15 miRNA signature that was predictive of overall survival with 72.7% sensitivity and 86.5% specificity in the validation set of tumors. We conclude that there is widespread dysregulation of miRNA expression in neuroblastoma tumors caused by both over-expression of the MYCN transcription factor and by large-scale chromosomal imbalances. MiRNA expression patterns are also predicative of clinical outcome, highlighting the potential for miRNA mediated diagnostics and therapeutics

Reconstructing the primordial power spectrum from the CMB

We propose a straightforward and model independent methodology for characterizing the sensitivity of CMB and other experiments to wiggles, irregularities, and features in the primordial power spectrum. Assuming that the primordial cosmological perturbations are adiabatic, we present a function space generalization of the usual Fisher matrix formalism, applied to a CMB experiment resembling Planck with and without ancillary data. This work is closely related to other work on recovering the inflationary potential and exploring specific models of non-minimal, or perhaps baroque, primordial power spectra. The approach adopted here, however, most directly expresses what the data is really telling us. We explore in detail the structure of the available information and quantify exactly what features can be reconstructed and at what statistical significance.Comment: 43 pages Revtex, 23 figure

Precious Metals in SDSS Quasar Spectra. II. Tracking the Evolution of Strong, 0.4 < z < 2.3 Mg II Absorbers with Thousands of Systems

We have performed an analysis of over 34,000 Mg II doublets at 0.36 < z < 2.29 in Sloan Digital Sky Survey (SDSS) Data Release 7 quasar spectra; the catalog, advanced data products, and tools for analysis are publicly available. The catalog was divided into 14 small redshift bins with roughly 2500 doublets in each and from Monte Carlo simulations, we estimate 50% completeness at rest equivalent width W_r ≈ 0.8 Å. The equivalent width frequency distribution is described well by an exponential model at all redshifts, and the distribution becomes flatter with increasing redshift, i.e., there are more strong systems relative to weak ones. Direct comparison with previous SDSS Mg II surveys reveals that we recover at least 70% of the doublets in these other catalogs, in addition to detecting thousands of new systems. We discuss how these surveys came by their different results, which qualitatively agree but because of the very small uncertainties, differ by a statistically significant amount. The estimated physical cross section of Mg II-absorbing galaxy halos increased approximately threefold from z = 0.4 to z = 2.3, while the W_r ≥ 1 Å absorber line density, dN_(Mg II)/dX, grew by roughly 45%. Finally, we explore the different evolution of various absorber populations—damped Lyα absorbers, Lyman limit systems, strong C IV absorbers, and strong and weaker Mg II systems—across cosmic time (0 < z < 6)

Precious Metals in SDSS Quasar Spectra I: Tracking the Evolution of Strong, 1.5 < z < 4.5 CIV Absorbers with Thousands of Systems

We have vastly increased the CIV statistics at intermediate redshift by surveying the thousands of quasars in the Sloan Digital Sky Survey Data-Release 7. We visually verified over 16,000 CIV systems with 1.46 < z < 4.55---a sample size that renders Poisson error negligible. Detailed Monte Carlo simulations show we are approximately 50% complete down to rest equivalent widths W_r ~ 0.6 \AA. We analyzed the sample as a whole and in ten small redshift bins with approximately 1500 doublets each. The equivalent width frequency distributions f(W_r) were well modeled by an exponential, with little evolution in shape. In contrast with previous studies that modeled the frequency distribution as a single power law, the fitted exponential gives a finite mass density for the CIV ions. The co-moving line density dN_CIV/dX evolved smoothly with redshift, increasing by a factor of 2.37+/-0.09 from z = 4.55 to 1.96, then plateauing at dN_CIV/dX ~ 0.34 for z = 1.96 to 1.46. Comparing our SDSS sample with z < 1 (ultraviolet) and z > 5 (infrared) surveys, we see an approximately 10-fold increase in dN_CIV/dX over z ~ 6 --> 0, for W_r >= 0.6 \AA. This suggests a monotonic and significant increase in the enrichment of gas outside galaxies over the 12 Gyr lifetime of the universe.Comment: 17 pages (emulateapj), 13 figures, 4 tables; accepted to ApJ and in press; also see http://igmabsorbers.inf

Constraints on neutrino masses from WMAP5 and BBN in the lepton asymmetric universe

In this paper, we put constraints on neutrino properties such as mass $m_{\nu}$ and degeneracy parameters $\xi_i$ from WMAP5 data and light element abundances by using a Markov chain Monte Carlo (MCMC) approach. In order to take consistently into account the effects of the degeneracy parameters, we run the Big Bang Nucleosynthesis code for each value of $\xi_i$ and the other cosmological parameters to estimate the Helium abundance, which is then used to calculate CMB anisotropy spectra instead of treating it as a free parameter. We find that the constraint on $m_{\nu}$ is fairly robust and does not vary very much even if the lepton asymmetry is allowed, and is given by $\sum m_\nu < 1.3 \rm eV$ ($95$).Comment: 19 pages, 7 figures, 5 table