Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects

The lipase inhibitor, orlistat, is used in the treatment of obesity and reduces fat absorption by about 30%. However, the mean weight loss induced by orlistat is less than expected for the degree of fat malabsorption. It was hypothesised that lipase inhibition with orlistat attenuates the suppressive effects of oral fat on subsequent energy intake in normal-weight subjects. Fourteen healthy, lean subjects (nine males, five females; aged 25 +/- 1.3 years) were studied twice, in a double-blind fashion. The subjects received a high-fat yoghurt 'preload' (males 400 g (2562 kJ); females 300 g (1923 kJ)), containing orlistat (120 mg) on one study day (and no orlistat on the other 'control' day), 30 min before ad libitum access to food and drinks; energy intake was assessed during the following 8 h. Blood samples were taken at regular intervals for the measurement of plasma cholecystokinin (CCK). Each subject performed a 3 d faecal fat collection following each study. Energy intake during the day was greater following orlistat (10,220 (SEM 928) kJ) v. control (9405 (SEM 824) kJ) (P=0.02). On both days plasma CCK increased (P<0.05) after the preload. Plasma CCK 20 min following ingestion of the preload was less after orlistat (4.1 (SEM 0.9) pmol/l) v. control (5.3 (SEM 0.9) pmol/l (P=0.028); however there was no difference in the area under the curve 0-510 min between the two study days. Fat excretion was greater following orlistat (1017 (SEM 168) kJ) v. control (484 (SEM 90) kJ) (P=0.004). In conclusion, in healthy, lean subjects the acute inhibitory effect of fat on subsequent energy intake is attenuated by orlistat and the increase in energy intake approximates the energy lost due to fat malabsorption.Deirdre O’Donovan, Christine Feinle-Bisset, Judith Wishart and Michael Horowit

An a priori investigation of astrophysical false positives in ground-based transiting planet surveys

Astrophysical false positives due to stellar eclipsing binaries pose one of the greatest challenges to ground-based surveys for transiting Hot Jupiters. We have used known properties of multiple star systems and Hot Jupiter systems to predict, a priori, the number of such false detections and the number of genuine planet detections recovered in two hypothetical but realistic ground-based transit surveys targeting fields close to the galactic plane (b~10 degrees): a shallow survey covering a magnitude range 10<V<13, and a deep survey covering a magnitude range 15<V<19. Our results are consistent with the commonly-reported experience of false detections outnumbering planet detections by a factor of ~10 in shallow surveys, while in our synthetic deep survey we find ~1-2 false detections for every planet detection. We characterize the eclipsing binary configurations that are most likely to cause false detections and find that they can be divided into three main types: (i) two dwarfs undergoing grazing transits, (ii) two dwarfs undergoing low-latitude transits in which one component has a substantially smaller radius than the other, and (iii) two eclipsing dwarfs blended with one or more physically unassociated foreground stars. We also predict that a significant fraction of Hot Jupiter detections are blended with the light from other stars, showing that care must be taken to identify the presence of any unresolved neighbors in order to obtain accurate estimates of planetary radii. This issue is likely to extend to terrestrial planet candidates in the CoRoT and Kepler transit surveys, for which neighbors of much fainter relative brightness will be important.Comment: 33 pages, 7 figures, 4 tables; To be published in The Astrophysical Journa

Future Directions in Astronomy Visualisation

Despite the large budgets spent annually on astronomical research equipment such as telescopes, instruments and supercomputers, the general trend is to analyse and view the resulting datasets using small, two-dimensional displays. We report here on alternative advanced image displays, with an emphasis on displays that we have constructed, including stereoscopic projection, multiple projector tiled displays and a digital dome. These displays can provide astronomers with new ways of exploring the terabyte and petabyte datasets that are now regularly being produced from all-sky surveys, high-resolution computer simulations, and Virtual Observatory projects. We also present a summary of the Advanced Image Displays for Astronomy (AIDA) survey which we conducted from March-May 2005, in order to raise some issues pertitent to the current and future level of use of advanced image displays.Comment: 13 pages, 2 figures, accepted for publication in PAS

Labour efficiency on-farm

End of project reportImprovements in milking efficiency have a greater influence than any other aspect of the dairy farmers work on overall farm labour inputs (Whipp, 1992). In order to facilitate the examination of milking process labour inputs, the milking process may be divided into the following three components: herding pre and post milking (transfer of cows to and from the milking parlour); milking (milking tasks / work routines within the parlour); and washing (washing of milking machine and yard). Meanwhile, within milking specifically, the number of cows milked per operator per hour is the best measure of both the performance of the operator and the milking installation (Clough, 1978). This is affected by the following three factors: the milking times of the cows, the number and arrangement of the milking units, and the operator’s work routine (Whipp, 1992). The addition of extra milking units will only increase milking performance if the operator has idle time during milking (Hansen, 1999)

Gastrointestinal tract size, total-tract digestibility, and rumen microflora in different dairy cow genotypes

peer-reviewedThe superior milk production efficiency of Jersey (JE) and Jersey × Holstein-Friesian (JE × HF) cows compared with Holstein-Friesian (HF) has been widely published. The biological differences among dairy cow genotypes, which could contribute to the milk production efficiency differences, have not been as widely studied however. A series of component studies were conducted using cows sourced from a longer-term genotype comparison study (JE, JE × HF, and HF). The objectives were to (1) determine if differences exist among genotypes regarding gastrointestinal tract (GIT) weight, (2) assess and quantify whether the genotypes tested differ in their ability to digest perennial ryegrass, and (3) examine the relative abundance of specific rumen microbial populations potentially relating to feed digestibility. Over 3 yr, the GIT weight was obtained from 33 HF, 35 JE, and 27 JE × HF nonlactating cows postslaughter. During the dry period the cows were offered a perennial ryegrass silage diet at maintenance level. The unadjusted GIT weight was heavier for the HF than for JE and JE × HF. When expressed as a proportion of body weight (BW), JE and JE × HF had a heavier GIT weight than HF. In vivo digestibility was evaluated on 16 each of JE, JE × HF, and HF lactating dairy cows. Cows were individually stalled, allowing for the total collection of feces and were offered freshly cut grass twice daily. During this time, daily milk yield, BW, and dry matter intake (DMI) were greater for HF and JE × HF than for JE; milk fat and protein concentration ranked oppositely. Daily milk solids yield did not differ among the 3 genotypes. Intake capacity, expressed as DMI per BW, tended to be different among treatments, with JE having the greatest DMI per BW, HF the lowest, and JE × HF being intermediate. Production efficiency, expressed as milk solids per DMI, was higher for JE than HF and JE × HF. Digestive efficiency, expressed as digestibility of dry matter, organic matter, N, neutral detergent fiber, and acid detergent fiber, was higher for JE than HF. In grazing cows (n = 15 per genotype) samples of rumen fluid, collected using a transesophageal sampling device, were analyzed to determine the relative abundance of rumen microbial populations of cellulolytic bacteria, protozoa, and fungi. These are critically important for fermentation of feed into short-chain fatty acids. A decrease was observed in the relative abundance of Ruminococcus flavefaciens in the JE rumen compared with HF and JE × HF. We can deduce from this study that the JE genotype has greater digestibility and a different rumen microbial population than HF. Jersey and JE × HF cows had a proportionally greater GIT weight than HF. These differences are likely to contribute to the production efficiency differences among genotypes previously reported

c-axis Josephson Tunnelling in Twinned and Untwinned YBCO-Pb Junctions

Within a microscopic two band model of planes and chains with a pairing potential in the planes and off diagonal pairing between planes and chains we find that the chains make the largest contribution to the Josephson tunnelling current and that through them the d-wave part of the gap contributes to the current. This is contrary to the usual assumption that for a d-wave tetragonal superconductor the c-axis Josephson current for incoherent tunnelling into an s-wave superconductor is zero while that of a d-wave orthorhombic superconductor with a small s-wave component to its gap it is small but non-zero. Nevertheless it has been argued that the effect of twins in YBCO would lead to cancellation between pairs of twins and so the observation of a current in c-axis YBCO-Pb experiments is evidence against a d-wave type order parameter. We argue that both theory and experiment give evidence that the two twin orientations are not necessarily equally abundant and that the ratio of tunnelling currents in twinned and untwinned materials should be related to the relative abundance of the two twin orientations.Comment: 6 pages, RevTeX 3.0, 15 PostScript figur

Absolute properties of the low-mass eclipsing binary CM Draconis

Spectroscopic and eclipsing binary systems offer the best means for determining accurate physical properties of stars, including their masses and radii. The data available for low-mass stars have yielded firm evidence that stellar structure models predict smaller radii and higher effective temperatures than observed, but the number of systems with detailed analyses is still small. In this paper we present a complete reanalysis of one of such eclipsing systems, CM Dra, composed of two dM4.5 stars. New and existing light curves as well as a radial velocity curve are modeled to measure the physical properties of both components. The masses and radii determined for the components of CM Dra are M1=0.2310+/-0.0009 Msun, M2=0.2141+/-0.0010 Msun, R1=0.2534+/-0.0019 Rsun, and R2=0.2396+/-0.0015 Rsun. With relative uncertainties well below the 1% level, these values constitute the most accurate properties to date for fully convective stars. This makes CM Dra a valuable benchmark for testing theoretical models. In comparing our measurements with theory, we confirm the discrepancies reported previously for other low-mass eclipsing binaries. These discrepancies seem likely to be due to the effects of magnetic activity. We find that the orbit of this system is slightly eccentric, and we have made use of eclipse timings spanning three decades to infer the apsidal motion and other related properties.Comment: 19 pages, 9 figures. Accepted for publication in Ap

Evaluation of the theoretical and in-use performance of Exhaust Air Heat Pumps

Integrated units that combine Exhaust Air Heat Pumps (EAHPs) with Heat Recovery Ventilation (HRV) and, in some instances, Domestic Hot Water Storage (DHW), are becoming increasingly popular in the domestic market across Europe with over 24,000 EAHPs purchased in the EU in 2017 alone. Early research into using EAHPs demonstrated energy savings being conservatively between 20% and 50% when compared to conventional systems. Recent research has suggested that, in reality, EAHPs in-use energy performance can be worse than that estimated by various standardised theoretical assessment methods (COP/SPF in the range of 0.4 to 6.0). More worryingly, published data on this in-use operation is effectively non-existent for NZEB type dwellings and few studies have stress tested the robustness of the EN standards in accounting for the effects of in-use operation. The study presented in this paper investigated whether the standard methods used to predict in-use energy performance are sufficiently robust and adequately capture operational performance for EAHP systems. The energy performance of two identical EAHP systems in Ireland (one rural/ one urban) were monitored for close to 12 months. During the live in-use monitoring period, the EAHPs had ‘heat-pump/heat recovery only’ operating mode ratios of 16%/84% and 22%/77% for rural and urban systems respectively. The average HRE in-use efficiency was 92% and 64% for the rural and urban systems respectively. While the manufacturers stated Seasonal performance factors (SPF) ranging from 2.2 (for DHW) to 5.8 (for Space Heating), the average in-use SPF was found to vary between 1.7 and 3.8 depending on the boundary reported and the location. More research is urgently required in order to bring much needed clarity for designers and energy assessors regarding which boundaries can be universally applied to EAHP systems. Given the range of SPF which could apply to the HP’s examined, the paper highlights the importance of ensuring that realistic indicators of in use performance are provided, aiding appropriate decision-making by policymakers, industry and end-users