The RAG Model: a new paradigm for genetic risk stratification in multiple myeloma

Molecular studies have shown that multiple myeloma is a highly genetically heterogonous disease which may manifest itself as any number of diverse subtypes each with variable clinicopathological features and outcomes. Given this genetic heterogeneity, a universal approach to treatment of myeloma is unlikely to be successful for all patients and instead we should strive for the goal of personalised therapy using rationally informed targeted strategies. Current DNA sequencing technologies allow for whole genome and exome analysis of patient myeloma samples that yield vast amounts of genetic data and provide a mutational overview of the disease. However, the clinical utility of this information currently lags far behind the sequencing technology which is increasingly being incorporated into clinical practice. This paper attempts to address this shortcoming by proposing a novel genetically based “traffic-light” risk stratification system for myeloma, termed the RAG (Red, Amber, Green) model, which represents a simplified concept of how complex genetic data may be compressed into an aggregate risk score. The model aims to incorporate all known clinically important trisomies, translocations, and mutations in myeloma and utilise these to produce a score between 1.0 and 3.0 that can be incorporated into diagnostic, prognostic, and treatment algorithms for the patient

A Buffer Stocks Model for Stabilizing Price of Staple Food with Considering the Expectation of Non Speculative Wholesaler

This paper is a study of price stabilization in the staple food distribution system. All stakeholders experience market risks due to some possibility causes of price volatility. Many models of price stabilization had been developed by employing several approaches such as floor-ceiling prices, buffer funds, export or import taxes, and subsidies. In the previous researches, the models were expanded to increase the purchasing price for producer and decrease the selling price for consumer. Therefore, the policy can influence the losses for non-speculative wholesaler that is reflected by the descending of selling quantity and ascending of the stocks. The objective of this model is not only to keep the expectation of both producer and consumer, but also to protect non-speculative wholesaler from the undesirable result of the stabilization policy. A nonlinear programming model was addressed to determine the instruments of intervention program. Moreover, the result shows that the wholesaler behavior affects the intervention costs. Index Terms Buffer stocks, Price stabilization, Nonlinear programming, Wholesaler behavior

Swift observations of the 2006 outburst of the recurrent nova RS Ophiuchi: II. 1D hydrodynamical models of wind driven shocks

Following the early Swift X-ray observations of the latest outburst of the recurrent nova RS Ophiuchi in February 2006 (Paper I), we present new 1D hydrodynamical models of the system which take into account all three phases of the remnant evolution. The models suggest a novel way of modelling the system by treating the outburst as a sudden increase then decrease in wind mass-loss rate and velocity. The differences between this wind model and previous Primakoff-type simulations are described. A more complex structure, even in 1D, is revealed through the presence of both forward and reverse shocks, with a separating contact discontinuity. The effects of radiative cooling are investigated and key outburst parameters such as mass-loss rate, ejecta velocity and mass are varied. The shock velocities as a function of time are compared to the ones derived in Paper I. We show how the manner in which the matter is ejected controls the evolution of the shock and that for a well-cooled remnant, the shock deceleration rate depends on the amount of energy that is radiated away.Comment: 9 pages, 5 figure

Improving wafer-scale Josephson junction resistance variation in superconducting quantum coherent circuits

Quantum bits, or qubits, are an example of coherent circuits envisioned for next-generation computers and detectors. A robust superconducting qubit with a coherent lifetime of $O$(100 $\mu$s) is the transmon: a Josephson junction functioning as a non-linear inductor shunted with a capacitor to form an anharmonic oscillator. In a complex device with many such transmons, precise control over each qubit frequency is often required, and thus variations of the junction area and tunnel barrier thickness must be sufficiently minimized to achieve optimal performance while avoiding spectral overlap between neighboring circuits. Simply transplanting our recipe optimized for single, stand-alone devices to wafer-scale (producing 64, 1x1 cm dies from a 150 mm wafer) initially resulted in global drifts in room-temperature tunneling resistance of $\pm$ 30%. Inferring a critical current $I_{\rm c}$ variation from this resistance distribution, we present an optimized process developed from a systematic 38 wafer study that results in $<$ 3.5% relative standard deviation (RSD) in critical current ($\equiv \sigma_{I_{\rm c}}/\left\langle I_{\rm c} \right\rangle$) for 3000 Josephson junctions (both single-junctions and asymmetric SQUIDs) across an area of 49 cm$^2$. Looking within a 1x1 cm moving window across the substrate gives an estimate of the variation characteristic of a given qubit chip. Our best process, utilizing ultrasonically assisted development, uniform ashing, and dynamic oxidation has shown $\sigma_{I_{\rm c}}/\left\langle I_{\rm c} \right\rangle$ = 1.8% within 1x1 cm, on average, with a few 1x1 cm areas having $\sigma_{I_{\rm c}}/\left\langle I_{\rm c} \right\rangle$ $<$ 1.0% (equivalent to $\sigma_{f}/\left\langle f \right\rangle$ $<$ 0.5%). Such stability would drastically improve the yield of multi-junction chips with strict critical current requirements.Comment: 10 pages, 4 figures. Revision includes supplementary materia

Violation of the Leggett-Garg inequality with weak measurements of photons

By weakly measuring the polarization of a photon between two strong polarization measurements, we experimentally investigate the correlation between the appearance of anomalous values in quantum weak measurements, and the violation of realism and non-intrusiveness of measurements. A quantitative formulation of the latter concept is expressed in terms of a Leggett-Garg inequality for the outcomes of subsequent measurements of an individual quantum system. We experimentally violate the Leggett-Garg inequality for several measurement strengths. Furthermore, we experimentally demonstrate that there is a one-to-one correlation between achieving strange weak values and violating the Leggett-Garg inequality.Comment: 5 pages, 4 figure

The Distance to Nova V959 Mon from VLA Imaging

Determining reliable distances to classical novae is a challenging but crucial step in deriving their ejected masses and explosion energetics. Here we combine radio expansion measurements from the Karl G. Jansky Very Large Array with velocities derived from optical spectra to estimate an expansion parallax for nova V959 Mon, the first nova discovered through its gamma-ray emission. We spatially resolve the nova at frequencies of 4.5-36.5 GHz in nine different imaging epochs. The first five epochs cover the expansion of the ejecta from 2012 October to 2013 January, while the final four epochs span 2014 February to 2014 May. These observations correspond to days 126 through 199 and days 615 through 703 after the first detection of the nova. The images clearly show a non-spherical ejecta geometry. Utilizing ejecta velocities derived from 3D modelling of optical spectroscopy, the radio expansion implies a distance between 0.9 +/- 0.2 and 2.2 +/- 0.4 kpc, with a most probable distance of 1.4 +/- 0.4 kpc. This distance implies a gamma-ray luminosity much less than the prototype gamma-ray-detected nova, V407 Cyg, possibly due to the lack of a red giant companion in the V959 Mon system. V959 Mon also has a much lower gamma-ray luminosity than other classical novae detected in gamma-rays to date, indicating a range of at least a factor of 10 in the gamma-ray luminosities for these explosions.Comment: 11 pages, 8 figures, 3 tables, submitted to ApJ 2015-01-21, under revie

Using Intelligent Agents to Manage Business Processes

This paper describes work undertaken in the ADEPT (Advanced Decision Environment for Process Tasks) project towards developing an agent-based infrastructure for managing business processes. We describe how the key technology of negotiating, service providing, autonomous agents was realised and demonstrate how this was applied to the BT business process of providing a customer quote for network services

Twisted Fermi surface of a thin-film Weyl semimetal

The Fermi surface of a conventional two-dimensional electron gas is equivalent to a circle, up to smooth deformations that preserve the orientation of the equi-energy contour. Here we show that a Weyl semimetal confined to a thin film with an in-plane magnetization and broken spatial inversion symmetry can have a topologically distinct Fermi surface that is twisted into a \mbox{figure-8} $-$ opposite orientations are coupled at a crossing which is protected up to an exponentially small gap. The twisted spectral response to a perpendicular magnetic field $B$ is distinct from that of a deformed Fermi circle, because the two lobes of a \mbox{figure-8} cyclotron orbit give opposite contributions to the Aharonov-Bohm phase. The magnetic edge channels come in two counterpropagating types, a wide channel of width $\beta l_m^2\propto 1/B$ and a narrow channel of width $l_m\propto 1/\sqrt B$ (with $l_m=\sqrt{\hbar/eB}$ the magnetic length and $\beta$ the momentum separation of the Weyl points). Only one of the two is transmitted into a metallic contact, providing unique magnetotransport signatures.Comment: V4: 10 pages, 14 figures. Added figure and discussion about "uncrossing deformations" of oriented contours, plus minor corrections. Published in NJ

The Economics of Selling Crop Residue Biomass for Cellulosic Ethanol Production at the Farm Level

A partial budget decision making framework has been developed to assist crop producers in analyzing the profitability of selling cellulosic biomass from their fields for ethanol production. A multidisciplinary approach is taken in assessing the agronomic and economic factors relevant to biomass contract sales decisions – with direct application made to western Great Plains cropping systems and enterprises. Within this framework the benefits of increased revenue from cellulosic biomass contract sales and potential government assistance payments are considered against possible decreased revenue from diminished crop yields resulting from less crop residue cover and subsequent soil moisture evaporation. Increased biomass harvesting and handling are also considered, as is the cost of replacing crop nutrients removed as part of biomass harvest operations. Examples of the profitability of cellulosic biomass contract sales in center pivot irrigated corn and non-irrigated wheat enterprises are shown.Resource /Energy Economics and Policy,

Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies

Acknowledgements We thank Craig Lambert for his help in processing the MRS data. The study was funded by the Sir Jules Thorn Charitable Trust (grant ref: 05/JTA) and was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre and the Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust and Newcastle University and the NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia based at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge.Peer reviewedPublisher PD