Orbiter thermal pressure drop characteristics for shuttle orbiter thermal protection system components: High density tile, low density tile, densified low density tile, and strain isolation pad

Pressure drop tests were conducted on available samples of low and high density tile, densified low density tile, and strain isolation pads. The results are presented in terms of pressure drop, material thickness and volume flow rate. Although the test apparatus was only capable of a small part of the range of conditions to be encountered in a Shuttle Orbiter flight, the data serve to determine the type of flow characteristics to be expected for each material type tested; the measured quantities also should serve as input for initial venting and flow through analysis

Noise reduction evaluation of grids in a supersonic air stream with application to Space Shuttle

Near field acoustic measurements were obtained for a model supersonic air jet perturbed by a screen. Noise reduction potential in the vicinity of the space shuttle vehicle during ground launch when the rocket exhaust flow is perturbed by a grid was determined. Both 10 and 12 mesh screens were utilized for this experiment, and each exhibited a noise reduction only at very low frequencies in the near field forward arc. A power spectrum analysis revealed that a modest reduction of from 3 to 5 decibels exists below a Strouhal number S sub t = 0.11. Above S sub t = 0.11 screen harmonics increased the observed sound pressure level. The favorable noise reductions obtained with screens for S sub t 0.11 may be of substantial interest for the space shuttle at ground launch

Pre- and post-operative gait analysis for evaluation of neck pain in chronic whiplash

<p>Abstract</p> <p>Introduction</p> <p>Chronic neck pain after whiplash is notoriously refractory to conservative treatment, and positive radiological findings to explain the symptoms are scarce. The apparent disproportionality between subjective complaints and objective findings is significant for the planning of treatment, impairment ratings, and judicial questions on causation. However, failure to identify a symptom's focal origin with routine imaging studies does not invalidate the symptom per se. It is therefore of a general interest both to develop effective therapeutic strategies in chronic whiplash, and to establish techniques for objectively evaluation of treatment outcomes.</p> <p>Methods</p> <p>Twelve patients with chronic neck pain after whiplash underwent pre- and postoperative computerized 3D gait analysis.</p> <p>Results</p> <p>Significant improvement was found in all gait parameters, cervical range-of-motion, and self reported pain (VAS).</p> <p>Conclusion</p> <p>Chronic neck pain is associated with abnormal cervical spine motion and gait patterns. 3D gait analysis is a useful instrument to assess the outcome of treatment for neck pain.</p

Advantages of additive manufacturing for biomedical applications of polyhydroxyalkanoates

In recent years, biopolymers have been attracting the attention of researchers and special-ists from different fields, including biotechnology, material science, engineering, and medicine. The reason is the possibility of combining sustainability with scientific and technological progress. This is an extremely broad research topic, and a distinction has to be made among different classes and types of biopolymers. Polyhydroxyalkanoate (PHA) is a particular family of polyesters, synthetized by microorganisms under unbalanced growth conditions, making them both bio-based and biodegradable polymers with a thermoplastic behavior. Recently, PHAs were used more intensively in biomedical applications because of their tunable mechanical properties, cytocompatibility, adhesion for cells, and controllable biodegradability. Similarly, the 3D-printing technologies show increasing potential in this particular field of application, due to their advantages in tailor-made design, rapid prototyping, and manufacturing of complex structures. In this review, first, the synthesis and the production of PHAs are described, and different production techniques of medical implants are compared. Then, an overview is given on the most recent and relevant medical applications of PHA for drug delivery, vessel stenting, and tissue engineering. A special focus is reserved for the inno-vations brought by the introduction of additive manufacturing in this field, as compared to the traditional techniques. All of these advances are expected to have important scientific and commer-cial applications in the near future

Exploring Wave-Wave Interactions in a General Circulation Model

Nonlinear interactions involving Kelvin waves with (periods, zonal wave numbers) = (3.7d, s =− 1) (UFKW1) and = (2.4d, s =− 1) (UFKW2) and s = 0 and s = 1 quasi 9 day waves (Q9DW) with diurnal tides DW1, DW2, DW3, DE2, and DE3 are explored within a National Center for Atmospheric Research (NCAR) thermosphere-ionosphere-mesosphere electrodynamics general circulation model (TIME-GCM) simulation driven at its ∼30 km lower boundary by interpolated 3-hourly output from Modern-Era Retrospective Analysis for Research and Applications (MERRA). The existence of nonlinear wave-wave interactions between the above primary waves is determined by the presence of secondary waves (SWs) with frequencies and zonal wave numbers that are the sums and differences of those of the primary (interacting) waves. Focus is on 10–21 April 2009, when the nontidal dynamics in the mesosphere-lower thermosphere (MLT) region is dominated by UFKW and when identification of SW is robust. Fifteen SWs are identified in all. An interesting triad is identified involving UFKW1, DE3, and a secondary UFKW4 = (1.5d, s =− 2): The UFKW1-DE3 interaction produces UFKW4, the UFKW4-DE3 interaction produces UFKW1, and the UFKW1 interaction with UFKW4 produces DE3. At 120 km the dynamic range of the reconstructed latitude-longitude zonal wind field due to all of the SW is roughly half that of the primary waves, which produced them. This suggests that nonlinear wave-wave interactions could significantly modify the way that the lower atmosphere couples with the ionosphere

Hyperfine-structure study in the P sequence of 23 Na using quantum-beam spectroscopy

Describes use of the quantum-beat method to study hyperfine structure in the 5 2 P 3/2 and 6 2 P 3/2 states of 23 Na. A pulsed dye laser, frequency-doubled into the UV region, was used to excite sodium atoms abruptly in a beam. The fluorescent light was recorded with a fast transient digitiser, interfaced to a micro-computer. Theoretical calculations using many-body perturbation theory were performed for the entire P sequence measured so far, taking polarisation and correlation effects into account separately. Very good agreement between experimental and theoretical values was obtained

Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats

<p>Abstract</p> <p>Background</p> <p>Acute alcohol (EtOH) intoxication decreases muscle protein synthesis via inhibition of mTOR-dependent translation initiation. However, these studies have been performed in relatively young rapidly growing rats in which muscle protein accretion is more sensitive to growth factor and nutrient stimulation. Furthermore, some in vivo-produced effects of EtOH vary in an age-dependent manner. The hypothesis tested in the present study was that young rats will show a more pronounced decrement in muscle protein synthesis than older mature rats in response to acute EtOH intoxication.</p> <p>Methods</p> <p>Male F344 rats were studied at approximately 3 (young) or 12 (mature) months of age. Young rats were injected intraperitoneally with 75 mmol/kg of EtOH, and mature rats injected with either 75 or 90 mmol/kg EtOH. Time-matched saline-injected control rats were included for both age groups. Gastrocnemius protein synthesis and the activity of the mTOR pathway were assessed 2.5 h after EtOH using [³H]-labeled phenylalanine and the phosphorylation of various protein factors known to regulate peptide-chain initiation.</p> <p>Results</p> <p>Blood alcohol levels (BALs) were lower in mature rats compared to young rats after administration of 75 mmol/kg EtOH (154 ± 23 vs 265 ± 24 mg/dL). However, injection of 90 mmol/kg EtOH in mature rats produced BALs comparable to that of young rats (281 ± 33 mg/dL). EtOH decreased muscle protein synthesis similarly in both young and high-dose EtOH-treated mature rats. The EtOH-induced changes in both groups were associated with a concomitant reduction in 4E-BP1 phosphorylation, and redistribution of eIF4E between the active eIF4E·eIF4G and inactive eIF4E·4EBP1 complex. Moreover, EtOH increased the binding of mTOR with raptor in a manner which appeared to be AMPK- and TSC-independent. In contrast, although muscle protein synthesis was unchanged in mature rats given low-dose EtOH, compared to control values, the phosphorylation of rpS6 and eIF4G was decreased.</p> <p>Conclusion</p> <p>These data indicate that muscle protein synthesis is equally sensitive to the inhibitory effects of EtOH in young rapidly growing rats and older mature rats which are growing more slowly, but that mature rats must be given a relatively larger dose of EtOH to achieve the same BAL. Based on the differential response in mature rats to low- and high-dose EtOH, the decreased protein synthesis was associated with a reduction in mTOR activity which was selectively mediated via a reduction in 4E-BP1 phosphorylation and an increase in mTOR·raptor formation.</p

On Assessing the Scope of Missing Native Americans in Nebraska: Results From a State-Wide Study and Recommendations for Future Research: On Assessing the Scope of Missing Native American Persons: Results From a State-Wide Study and Recommendations for Future Research

Recent legislation in multiple states has called for studies on the scope of missing Native American persons. Here we report on one such study from Nebraska by first describing the practical and methodological issues for researchers to consider when examining data on missing Native persons. Then, using data from four point-in-time-counts in 2020, rates of Native American missing persons as well as case contexts over the study period are reported. Findings show that Native Americans are disproportionately represented among Nebraska\u27s missing persons, that reports often involve minor boys, and that cases are dynamic and most are resolved quickly. Relatedly, most Native missing persons cases are only listed on the state clearinghouse, not the national missing persons lists. The paper is concluded with a discussion of specific directions for future research and policy regarding missing Native Americans

Identifying multiple coral reef regimes and their drivers across the Hawaiian archipelago

Loss of coral reef resilience can lead to dramatic changes in benthic structure, often called regime shifts, which significantly alter ecosystem processes and functioning. In the face of global change and increasing direct human impacts, there is an urgent need to anticipate and prevent undesirable regime shifts and, conversely, to reverse shifts in already degraded reef systems. Such challenges require a better understanding of the human and natural drivers that support or undermine different reef regimes. The Hawaiian archipelago extends across a wide gradient of natural and anthropogenic conditions and provides us a unique opportunity to investigate the relationships between multiple reef regimes, their dynamics and potential drivers. We applied a combination of exploratory ordination methods and inferential statistics to one of the most comprehensive coral reef datasets available in order to detect, visualize and define potential multiple ecosystem regimes. This study demonstrates the existence of three distinct reef regimes dominated by hard corals, turf algae or macroalgae. Results from boosted regression trees show nonlinear patterns among predictors that help to explain the occurrence of these regimes, and highlight herbivore biomass as the key driver in addition to effluent, latitude and depth