Improving the Sensitivity of Advanced LIGO Using Noise Subtraction

This paper presents an adaptable, parallelizable method for subtracting linearly coupled noise from Advanced LIGO data. We explain the features developed to ensure that the process is robust enough to handle the variability present in Advanced LIGO data. In this work, we target subtraction of noise due to beam jitter, detector calibration lines, and mains power lines. We demonstrate noise subtraction over the entirety of the second observing run, resulting in increases in sensitivity comparable to those reported in previous targeted efforts. Over the course of the second observing run, we see a 30% increase in Advanced LIGO sensitivity to gravitational waves from a broad range of compact binary systems. We expect the use of this method to result in a higher rate of detected gravitational-wave signals in Advanced LIGO data.Comment: 15 pages, 6 figure

The inter-rater reliability of the diagnosis of surgical site infection in the context of a clinical trial.

ObjectivesThe diagnosis of surgical site infection following endoprosthetic reconstruction for bone tumours is frequently a subjective diagnosis. Large clinical trials use blinded Central Adjudication Committees (CACs) to minimise the variability and bias associated with assessing a clinical outcome. The aim of this study was to determine the level of inter-rater and intra-rater agreement in the diagnosis of surgical site infection in the context of a clinical trial.Materials and methodsThe Prophylactic Antibiotic Regimens in Tumour Surgery (PARITY) trial CAC adjudicated 29 non-PARITY cases of lower extremity endoprosthetic reconstruction. The CAC members classified each case according to the Centers for Disease Control (CDC) criteria for surgical site infection (superficial, deep, or organ space). Combinatorial analysis was used to calculate the smallest CAC panel size required to maximise agreement. A final meeting was held to establish a consensus.ResultsFull or near consensus was reached in 20 of the 29 cases. The Fleiss kappa value was calculated as 0.44 (95% confidence interval (CI) 0.35 to 0.53), or moderate agreement. The greatest statistical agreement was observed in the outcome of no infection, 0.61 (95% CI 0.49 to 0.72, substantial agreement). Panelists reached a full consensus in 12 of 29 cases and near consensus in five of 29 cases when CDC criteria were used (superficial, deep or organ space). A stable maximum Fleiss kappa of 0.46 (95% CI 0.50 to 0.35) at CAC sizes greater than three members was obtained.ConclusionsThere is substantial agreement among the members of the PARITY CAC regarding the presence or absence of surgical site infection. Agreement on the level of infection, however, is more challenging. Additional clinical information routinely collected by the prospective PARITY trial may improve the discriminatory capacity of the CAC in the parent study for the diagnosis of infection.Cite this article: J. Nuttall, N. Evaniew, P. Thornley, A. Griffin, B. Deheshi, T. O'Shea, J. Wunder, P. Ferguson, R. L. Randall, R. Turcotte, P. Schneider, P. McKay, M. Bhandari, M. Ghert. The inter-rater reliability of the diagnosis of surgical site infection in the context of a clinical trial. Bone Joint Res 2016;5:347-352. DOI: 10.1302/2046-3758.58.BJR-2016-0036.R1

Large-Scale Image Processing with the ROTSE Pipeline for Follow-Up of Gravitational Wave Events

Electromagnetic (EM) observations of gravitational-wave (GW) sources would bring unique insights into a source which are not available from either channel alone. However EM follow-up of GW events presents new challenges. GW events will have large sky error regions, on the order of 10-100 square degrees, which can be made up of many disjoint patches. When searching such large areas there is potential contamination by EM transients unrelated to the GW event. Furthermore, the characteristics of possible EM counterparts to GW events are also uncertain. It is therefore desirable to be able to assess the statistical significance of a candidate EM counterpart, which can only be done by performing background studies of large data sets. Current image processing pipelines such as that used by ROTSE are not usually optimised for large-scale processing. We have automated the ROTSE image analysis, and supplemented it with a post-processing unit for candidate validation and classification. We also propose a simple ad hoc statistic for ranking candidates as more likely to be associated with the GW trigger. We demonstrate the performance of the automated pipeline and ranking statistic using archival ROTSE data. EM candidates from a randomly selected set of images are compared to a background estimated from the analysis of 102 additional sets of archival images. The pipeline's detection efficiency is computed empirically by re-analysis of the images after adding simulated optical transients that follow typical light curves for gamma-ray burst afterglows and kilonovae. We show that the automated pipeline rejects most background events and is sensitive to simulated transients to limiting magnitudes consistent with the limiting magnitude of the images

Energy requirements of a thermally processed ISRU radiation shield for a lunar habitat

The purpose of this study was to establish, on a first principles basis, the order of magnitude of energy requirements for a thermally processed, lunar regolith radiation shield constructed using an in-situ resource utilisation (ISRU) approach. This was done by developing a reference scenario habitat and using thermodynamic relationships and specific heat capacity expressions to determine the energy required to bring such a regolith volume up to sintering temperatures (c. 1375 K). Once the energy requirements were developed some power system architectures were outlined conceptually and a nuclear power plant of c. 400 kW was suggested as a means to supply the necessary energy. This is well beyond current space nuclear applications. The study concludes that it is likely that the most efficient near-term solution is chemical processing of regolith, from an energy requirements perspective. The technology is also more mature and likely to be delivered on near term projects as it does not require such scaled-up power system architectures. Alternatively, bringing storm shelters up with the habitat to provide a means of weathering major solar events, and adding additional radiation protection to habitat quarters, possibly through a water blanket or similar mechanism, could provide a non-ISRU solution with current technology. However, in the longer term, the development of MW-scale reactors or other power system architectures may permit a very large volume of material to be processed thermally for both construction material and volatile extraction, making a large, permanent human presence on the Moon more easily realisable

Introduction:Conceptualizing Hinterlands

This introduction first considers the history of the hinterland as not just any spatial distribution but one driven by and instrumental to the workings of the capitalist-colonialist-climatic assemblage. Subsequently, it contends that an interdisciplinary conceptual approach to hinterlands that straddles the humanities and social sciences allows for critical and engaged reflection on the haunting afterlives of colonialism, the logistical turn of global capitalism, the impending threat of environmental collapse, and persistent urban-suburban-rural-wilderness divides. The introduction closes by outlining how, together, the contributions to this volume make clear that while hinterlands are primarily realms of extraction and abandonment, they are places of possibility as well, where alternative ways of living together and new forms of care, including for the planet, may flourish

An analysis of the Research Fellowship Scheme of the Royal College of Surgeons of England.

BACKGROUND: The Research Fellowship Scheme of the Royal College of Surgeons of England commenced in 1993 with the aim of exposing selected surgical trainees to research techniques and methodology, with the hope of having an impact on surgical research and increasing the cadre of young surgeons who might decide to pursue an academic career in surgery. Over 11 million pounds sterling (approximately US 20 million dollars) has been invested in 264 fellowships. The College wished to evaluate the impact of the Scheme on the careers of research fellows, surgical research, and patient care. As the 10th anniversary of the Scheme approached. STUDY DESIGN: Two-hundred and sixty research fellows whose current addresses were available were sent a questionnaire. Two-hundred and thirty-eight (91.5%) responded. RESULTS: Three-quarters of the research fellows conducted laboratory-based research, with most of the remainder conducting patient-based clinical research. One-third of the fellows who have reached consultant status have an academic component to their post. The total number of publications based on fellowship projects was 531, with a median impact factor of 3.5. Almost all fellows had been awarded a higher degree or were working toward this. Half of the fellows received subsequent funding for research, mostly awarded by national or international funding bodies. CONCLUSIONS: The Research Fellowship Scheme of the Royal College of Surgeons of England has successfully supported many trainee surgeons in the initial phase of their research career. It has helped surgical research by increasing the pool of surgeons willing to embark on an academic career. Indirectly, patient care has benefited by promoting an evidence-based culture among young surgeons. Such schemes are relevant to surgical training programs elsewhere if more young surgeons are to be attracted into academic surgery

The causal role of left and right superior temporal gyri in speech perception in noise, a TMS study

Successful perception of speech in everyday listening conditions requires effective listening strategies to overcome common acoustic distortions, such as background noise. Convergent evidence from neuroimaging and clinical studies identify activation within the temporal lobes as key to successful speech perception. However, current neurobiological models disagree on whether the left temporal lobe is sufficient for successful speech perception or whether bilateral processing is required. We addressed this issue using TMS to selectively disrupt processing in either the left or right superior temporal gyrus (STG) of healthy participants to test whether the left temporal lobe is sufficient or whether both left and right STG are essential. Participants repeated keywords from sentences presented in background noise in a speech reception threshold task while receiving online repetitive TMS separately to the left STG, right STG, or vertex or while receiving no TMS. Results show an equal drop in performance following application of TMS to either left or right STG during the task. A separate group of participants performed a visual discrimination threshold task to control for the confounding side effects of TMS. Results show no effect of TMS on the control task, supporting the notion that the results of Experiment 1 can be attributed to modulation of cortical functioning in STG rather than to side effects associated with online TMS. These results indicate that successful speech perception in everyday listening conditions requires both left and right STG and thus have ramifications for our understanding of the neural organization of spoken language processing

Humanitarian aid as an integral part of the European Union's external action: the challenge of reconciling coherence and independence

The article focuses on the European Union's (EU) humanitarian aid policy. It addresses the challenge for the EU to deliver independent humanitarian aid while simultaneously seeking to establish more coherence between its external policies. The article examines how the EU tries to reconcile these potentially conflicting policy goals, both de jure and in practice. Empirically, it explores the interaction between EU humanitarian aid and development cooperation, the Common Foreign and Security Policy, and trade policy. While the independence of the humanitarian aid delivery is, for the most part, not being undermined, it remains difficult to establish positive synergies with other external policies because of institutional hurdles and legal constraints, as well as political obstacles and operational incompatibilities

Tick-borne Thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1

We show that tick-transmitted Thogoto virus is sensitive to interferon- induced nuclear Mx1 protein, which is known for its specific antiviral action against orthomyxoviruses. Influenza virus-susceptible BALB/c mice (lacking a functional Mx1 gene) developed severe disease symptoms and died within days after intracerebral or intraperitoneal infection with a lethal challenge dose of Thogoto virus. In contrast, Mx1-positive congenic, influenza virus- resistant BALB·A2G-Mx1 mice remained healthy and survived. Likewise, A2G, congenic B6·A2G-Mx1 and CBA·T9-Mx1 mice (derived from influenza virus- resistant wild mice) as well as Mx1-transgenic 979 mice proved to be resistant. Peritoneal macrophages and interferon-treated embryo cells from resistant mice exhibited the same resistance phenotype in vitro. Moreover, stable lines of transfected mouse 3T3 cells that constitutively express Mx1 protein showed increased resistance to Thogoto virus infection. We conclude that an Mx1-sensitive step has been conserved during evolution of orthomyxoviruses and suggest that the Mx1 gene in rodents may serve to combat infections by influenza virus-like arboviruses.</p