Multi-component Reaction Synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles Using Ultrasonication and Dmap as Catalyst

4-(Dimethylamino)pyridine was found to be the homogenous and efficient catalyst for one-pot, multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using ultrasonication at room temperature in ethanol solution within 35-50 min with yields of over 90%. This procedure offers various remarkable features such as short reaction times, clean reaction condition, excellent yields, and easy work-up methods

An efficient method for synthesis of stable phosphorus ylides and 1,4-diionic organophosphorus compounds in the presence of sodium dodecyl sulfate in aqueous media

AbstractStable crystalline phosphorus ylides and 1,4-diionic organophosphorus compounds were obtained in good to excellent yields from the 1:1:1 addition reaction between triphenylphosphine, dialkyl acetylenedicarboxylates and β-dicarbonyl or heterocyclic compounds, such as diethyl malonate, acetyl acetone, 1,3-diphenyl propane-1,3-dione, 1,3-dimethylbarbituric acid, meldrum’s acid, 2-benzoxazolinone, benzotirazole, and 2-thiazoline-2-thiol in the presence of sodium dodecyl sulfate as a surfactant in water. Green synthesis, mild conditions, decreasing timescale of reaction, low cost, and easy workup are the main advantages of this method

An efficient solvent-free synthesis of pyrido[2,3-d]pyrimidine derivatives utilizing lactic acid as green and eco-friendly catalyst

1368-1372An efficient, solvent-free and one-pot procedure for the synthesis of pyrido[2,3-d]pyrimidine derivatives by condensation of aromatic aldehydes, malononitrile and 6-amino-1,3-dimethyl uracil at 90°C catalyzed by lactic acid as an inexpensive, biological and eco-friendly compound is described. The remarkable benefits of this procedure are green and environmentally friendly reaction conditions, high yields, short reaction time, simple methodology and easy workup

An efficient solvent-free synthesis of pyrido[2,3-d]pyrimidine derivatives utilizing lactic acid as green and eco-friendly catalyst

An efficient, solvent-free and one-pot procedure for the synthesis of pyrido[2,3-d]pyrimidine derivatives by condensation of aromatic aldehydes, malononitrile and 6-amino-1,3-dimethyl uracil at 90°C catalyzed by lactic acid as an inexpensive, biological and eco-friendly compound is described. The remarkable benefits of this procedure are green and environmentally friendly reaction conditions, high yields, short reaction time, simple methodology and easy workup

Green Synthesis of Polysubstituted Quinolines and Xanthene Derivatives Promoted by Tartaric Acid as a Naturally Green Catalyst under Solvent-free Conditions

This method reported the use of tartaric acid as a green and highly efficient catalyst for the convenient synthesis of polysubstituted quinolines and xanthenes derivatives in excellent yields under solvent-free conditions. The main advantages of this one-pot procedure are the green and economic availability of the catalyst, simple experimental and work-up procedures

Three-component coupling approach for the synthesis of 4H-pyrans and pyran-annulated heterocyclic scaffolds utilizing Ag/TiO2 nano-thin films as robust recoverable catalyst

127-135As a segment of ongoing surveys and with the aim of expansion of environmentally benign processes, a series of biologically varied type of substituted 2-amino-3-cyano-4H-pyrans and pyran-annulated Scaffolds have been synthesized by tandem Knoevenagel-cyclocondensation of aldehydes, malononitrile, and C-H-activated acidic compounds in aqueous ethanol in the presence of Ag/TiO2 nano-thin films as an eco-friendly, recyclable, and, robust catalyst at 60°C. The salient features of this protocol are mild reaction conditions, producing target compounds in high yields, short reaction times, high atom economy, eco-friendly catalyst, easy isolation of products and no column chromatographic separation. Also, it is observed that the catalyst is highly stable during the reaction and several reuse times without observable loss in catalytic performance

Piperidine, an efficient base catalyst for the one-pot synthesis of 3,4-dihydropyrano[3,2-<i>c</i>]chromene derivatives

649-655An efficient and simple protocol for the one-pot three-component synthesis of 3,4-dihydropyrano[3,2-c]chromenes 4 is described, via the reaction of aromatic aldehydes 1, malononitril 2 and 4-hydroxycumarin 3 in the presence of 10 mol% of piperidine as catalyst, in ethanol (EtOH) at ambient temperature. Short reaction times, environmentally friendly procedure and excellent yields are the main advantages of this procedure, which makes it more economical than other environment-friendly methods

One-Pot Eco-Safe Saccharin-Catalyzed Procedure for Expedient and Convenient Synthesis of Dihydropyrano[2,3-<i>c</i>]pyrazole, Tetrahydrobenzo[<i>b</i>]pyran and Pyrano[2,3-<i>d</i>]pyrimidinone Scaffolds as a Green and Versatile Catalyst

A green and facile saccharin-catalyzed procedure is developed for the one-pot convenient synthesis of dihydropyrano[2,3-c]pyrazole, tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone scaffolds via multi-component tandem Knoevenagel cyclocondensation reaction. This procedure has the chief advantages of green, inexpensive and readily available catalyst, high atom-economy, high to quantitative yields and the reaction procedure is mild and involves facile workup procedure to obtain the desired products in short reaction times

Synthesis of pyrrole and furan derivatives in the presence of lactic acid as a catalyst

For the first time lactic acid was applied as an efficient and green catalyst for the one-pot synthesis of pyrrole and furan derivatives at ambient temperature in EtOH. This methodology includes a number of advantages such as: short reaction time, clean work-up, use of non toxic and expensive catalyst and high yield

Four-component clean process for the eco-friendly synthesis of 1<em>H</em>-pyrazolo [1,2-<em>b</em>]phthalazine-5,10-dione derivatives using Zn(OAc)₂.2H₂</em>O as an efficient catalyst under solvent-free conditions

843-851An efficient and convenient zinc acetate dihydrate (Zn(OAc)2.2H2O) catalyzed synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives has been accomplished via one-pot four-condensation of phthalic anhydride, hydrazine monohydrate, aromatic aldehydes derivatives and malononitrile under solvent-free conditions. The notable advantages of the present procedure are: operational simplicity, eco-friendly, environmentally benign nature, low-cost and non-toxic catalyst, no necessity of chromatographic purification steps, short reaction times and good to high yields