Microwave Imaging for Early Breast Cancer Detection: Current State, Challenges, and Future Directions

Breast cancer is the most commonly diagnosed cancer type and is the leading cause of cancer-related death among females worldwide. Breast screening and early detection are currently the most successful approaches for the management and treatment of this disease. Several imaging modalities are currently utilized for detecting breast cancer, of which microwave imaging (MWI) is gaining quite a lot of attention as a promising diagnostic tool for early breast cancer detection. MWI is a noninvasive, relatively inexpensive, fast, convenient, and safe screening tool. The purpose of this paper is to provide an up-to-date survey of the principles, developments, and current research status of MWI for breast cancer detection. This paper is structured into two sections; the first is an overview of current MWI techniques used for detecting breast cancer, followed by an explanation of the working principle behind MWI and its various types, namely, microwave tomography and radar-based imaging. In the second section, a review of the initial experiments along with more recent studies on the use of MWI for breast cancer detection is presented. Furthermore, the paper summarizes the challenges facing MWI as a breast cancer detection tool and provides future research directions. On the whole, MWI has proven its potential as a screening tool for breast cancer detection, both as a standalone or complementary technique. However, there are a few challenges that need to be addressed to unlock the full potential of this imaging modality and translate it to clinical settings

A Review on Membrane Biofouling: Prediction, Characterization, and Mitigation

Water scarcity is an increasing problem on every continent, which instigated the search for novel ways to provide clean water suitable for human use; one such way is desalination. Desalination refers to the process of purifying salts and contaminants to produce water suitable for domestic and industrial applications. Due to the high costs and energy consumption associated with some desalination techniques, membrane-based technologies have emerged as a promising alternative water treatment, due to their high energy efficiency, operational simplicity, and lower cost. However, membrane fouling is a major challenge to membrane-based separation as it has detrimental effects on the membrane’s performance and integrity. Based on the type of accumulated foulants, fouling can be classified into particulate, organic, inorganic, and biofouling. Biofouling is considered the most problematic among the four fouling categories. Therefore, proper characterization and prediction of biofouling are essential for creating efficient control and mitigation strategies to minimize the damage associated with biofouling. Moreover, the use of artificial intelligence (AI) in predicting membrane fouling has garnered a great deal of attention due to its adaptive capability and prediction accuracy. This paper presents an overview of the membrane biofouling mechanisms, characterization techniques, and predictive methods with a focus on AI-based techniques, and mitigation strategies

Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging

The field of cancer theranostics has grown rapidly in the past decade and innovative ‘biosmart’ theranostic materials are being synthesized and studied to combat the fast growth of cancer metastases. While current state-of-the-art oncology imaging techniques have decreased mortality rates, patients still face a diminished quality of life due to treatment. Therefore, improved diagnostics are needed to define in vivo tumor growths on a molecular level to achieve image-guided therapies and tailored dosage needs. This review summarizes in vivo studies that utilize contrast agents within the field of photoacoustic imaging—a relatively new imaging modality—for tumor detection, with a special focus on imaging and transducer parameters. This paper also details the different types of contrast agents used in this novel diagnostic field, i.e., organic-based, metal/inorganic-based, and dye-based contrast agents. We conclude this review by discussing the challenges and future direction of photoacoustic imaging

pH-Responsive Nanocarriers in Cancer Therapy

A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumor sites. Different intrinsic and extrinsic stimuli can be used to trigger drug release such as temperature, redox, ultrasound, magnetic field, and pH. The intracellular pH of solid tumors is maintained below the extracellular pH. Thus, pH-sensitive nanoparticles are highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review provides a survey of the different strategies used to develop pH-sensitive nanoparticles used in cancer therapy

Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment

Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. This review highlights the different types of NPs and the physiological characteristics of the tumor microenvironment (TME), and the mechanisms undertaken to safely deliver drugs to specific lesions. We review the principles and latest developments in the field of targeted NPs designed to target tumor vasculature compared to those designed to target cancer cells and their correlation with the TME. We discuss the advantages and limitations of each targeted drug delivery mechanism and future directions aiming to maximize their potential

Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer

Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydrophilic graphene quantum dots and triggered their release with ultrasound with the goal of developing a safer and well-controlled modality to deliver fluorescent markers to tumors. Our results confirmed the successful encapsulation of the QDs inside the core of the liposomes and showed no effect on the size or stability of the prepared liposomes. Our results also showed that low-frequency ultrasound is an effective method to release QDs encapsulated inside the liposomes in a spatially and temporally controlled manner to ensure the effective delivery of QDs to tumors while reducing their systemic toxicity