Monte-Carlo simulation of the Siemens Artiste linear accelerator flat 6 MV and flattening-filter-free 7 MV beam line.

The aim of our work is to provide the up-to-now missing information on the Siemens Artiste FFF 7 MV beam line using a Monte-Carlo model fit to the realistic dosimetric measurements at the linear accelerator in clinical use at our department. The main Siemens Artiste 6MV and FFF 7MV beams were simulated using the Geant4 toolkit. The simulations were compared with the measurements with an ionization chamber in a water phantom to verify the validation of simulation and tuning the primary electron parameters. Hereafter, other parameters such as surface dose, spectrum, electron contamination, symmetry, flatness/unflatness, slope, and characteristic off-axis changes were discussed for both Flat and FFF mode. The mean electron energy for the FFF beam was 8.8 MeV and 7.5 MeV for Flat 6 MV, the spread energy and spot size of the selected Gaussian distribution source were 0.4 MeV and 1mm, respectively. The dose rate of the FFF beam was 2.8 (2.96) times higher than for the flattened beam for a field size of 10×10 (20×20) cm2. The electron contamination has significant contribution to the surface dose especially for the flattened beam. The penumbra, surface dose and the mean energy of photons decrease by removing the flattening filter. Finally, the results show that off-axis changes have no strong effect on the mean energy of FFF beams, while this effect was more considerable for the flattened beam

Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number.

Although highly conformal dose distributions can be achieved by IMRT planning, this often requires a large number of segments or beams, resulting in increased treatment times. While flattening-filter-free beams offer a higher dose rate, even more segments may be required to create homogeneous target coverage. Therefore, it is worthwhile to systematically investigate the dependence of plan quality on gantry angles and number of segments for flat vs. FFF beams in IMRT planning. For the practical example of hypopharynx cancer, we present a planning study of flat vs. FFF beams using three different configurations of gantry angles and different segment numbers. The two beams are very similar in physical properties, and are hence well-suited for comparative planning. Starting with a set of plans of equal quality for flat and FFF beams, we assess how far the number of segments can be reduced before the plan quality is markedly compromised, and compare monitor units and treatment times for the resulting plans. As long as a sufficiently large number of segments is permitted, all planning scenarios give good results, independently of gantry angles and flat or FFF beams. For smaller numbers of segments, plan quality decreases both for flat and FFF energies; this effect is stronger for fewer gantry angles and for FFF beams. For low segment numbers, FFF plans are generally worse than the corresponding flat beam plans, but they are less sensitive to a decrease in segment number if many gantry angles are used (18 beams); in this case the quality of flat and FFF plans remains comparable even for few segments

Early Eocene magnetostratigraphy and tectonic evolution of the Xining Basin, NE Tibet

The Cenozoic strata of the Xining Basin, NE Tibet, have provided crucial records for understanding the tectonic and palaeo‐environmental evolution of the region. Yet, the age of the lower part of the sedimentary stratigraphy and, consequently, the early tectonic evolution of the basin remain debated. Here, we present the litho‐ and magnetostratigraphy of various early Eocene sections throughout the Xining Basin independently constrained by the U–Pb radiometric age of a carbonate bed. Our study extends the dated stratigraphy down to 53.0 Ma (C24n.1r) and reveals highly variable accumulation rates during the early Eocene ranging from 0.5 to 8 cm/ka. This is in stark contrast to the low but stable accumulation rates (2–3 cm/ka) observed throughout the overlying Palaeogene and Neogene strata. Such a pattern of basin infill is not characteristic of flexural subsidence as previously proposed, but rather supports an extensional origin of the Xining Basin with multiple depocentres, which subsequently coalesced into a more stable and slowly subsiding basin. Whether this extension was related to the far‐field effects of the subducting Pacific Plate or the India–Asia collision remains to be confirmed by future studies.European Research Council http://dx.doi.org/10.13039/501100000781Hessisches Ministerium für Wissenschaft und Kunst http://dx.doi.org/10.13039/50110000349

Results of the two-way anova with repeated measures and interactions (p-values of pairwise tests for the measures of quality).

<p>Results of the two-way anova with repeated measures and interactions (p-values of pairwise tests for the measures of quality).</p

mARC Treatment of Hypopharynx Carcinoma with Flat and Flattening-Filter-Free Beam Energies – A Planning Study

<div><p>Background</p><p>The recently implemented mARC-rotation-technique is capable to deliver high dose rate bursts. For the case of hypopharynx cancer plans we evaluate whether the mARC can achieve an advantage in treatment time in comparison to IMRT. These plans consider two arcs with flat and flattening filter free (FFF) beam energies.</p><p>Materials and Methods</p><p>For 8 hypopharynx-cancer patients step-and-shoot-IMRT and mARC plans were created retrospectively using flat and FFF beam energy. The comparison of the plan scenarios considered measures of quality for PTV coverage and sparing of organs at risk. All plans were irradiated on an anthromorphic phantom equipped with thermoluminescent dosimeters to measure scattered dose and treatment times.</p><p>Results</p><p>A visual comparison of the dose distribution did not show a marked preference for either technique or energy. The statistical evaluation yielded significant differences in favor of the mARC technique and the FFF energy. Scattered dose could be decreased markedly by the use of the mARC technique. Treatment times could be reduced up to 3 minutes with the use of mARC in comparison to IMRT. The high dose rate energy results in another time advantage of about 1 minute.</p><p>Conclusions</p><p>All four plan scenarios yielded equally good quality plans. A combination of the mARC technique with FFF 7 MV high dose rate resulted in a decrease of treatment times from about 9 minutes to 5–6 minutes in comparison to 6 MV IMRT.</p></div