Understanding Contextual Differences in Residential LTC Provision for Cross-National Research : Identifying Internationally Relevant CDEs

Long-term care (LTC) reflects a growing emphasis on person-centered care (PCC), with services oriented around individuals' needs and preferences. Addressing contextual and cultural differences across countries offers important insight into factors that facilitate or hinder application of PCC practices within and across countries. This article takes an international lens to consider country-specific contexts of LTC, describing preliminary steps to develop common data elements that capture contextual differences across LTC settings globally. Through an iterative series of online, telephone, and in-person sessions, we engaged in in-depth discussions with 11 colleague experts in residential LTC and coauthors from six countries (China and Hong Kong, England, Sweden, Thailand, Trinidad and Tobago, and the United States). Our discussions yielded rich narrative describing a vast range in types of LTC settings, leading to our development of a working definition of residential LTC. Scope of services, funding, ownership, and regulations varied greatly across countries and across different residential LTC settings within countries. Moving forward, we recommend expanding our activities to countries that reflect different stages of residential LTC development. Our goal is to contribute to a larger initiative underway by the WE-THRIVE consortium to establish a global research measurement infrastructure that advances PCC internationally.Peer reviewe

Molecular mechanisms of metastasis in prostate cancer

Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone

The Management and Creation of Knowledge: Do Wikis Help?

Wikis are frequently cited in Higher Education research as appropriate and powerful web spaces which provide opportunities to capture, discuss, and review individual, group, project or organisational activities. These activities, in turn, offer possibilities for knowledge development by utilising wiki collaborative active spaces. The chapter uses selected case studies examples to illustrate the use of wikis to support online community based tasks, project development/process, collaborative materials development and various student and peer supported activities. A key focus of the chapter centres on evaluating the effectiveness (or otherwise) of wikis to create online communities to support knowledge management (development, retention and transfer). See Choy & Ng (2007), Lamb (2004), Elgort (2008), Raman et al. (2005). By way of contextualising the studies, a variety of uses of wikis in higher education are reviewed as part of this chapter. See, for example, Lamb, (2004) Choy, & Ng, (2007), Doolan, (2006) Jones P. (2007) Raman, et al. (2005) Grierson, et al.,, (2004). Creation of knowledge sentence + refs? The chapter concludes with a review of the emergent themes arising and lessons learned from the case studies. This leads into a series of recommendations relating to the effective establishment, design, management and support and use of wikis to support knowledge creation and collaborative enterprise

Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration:disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling

The Notch ligand Jagged1 is subject to regulated intramembrane proteolysis (RIP) which yields a soluble ectodomain (sJag) and a soluble Jagged1 intracellular domain (JICD). The full-length Jagged1 protein enhances prostate cancer (PCa) cell proliferation and is highly expressed in metastatic cells. However, little is known regarding the mechanisms by which Jagged1 or its RIP-generated fragments might promote PCa bone metastasis. In the current study we show that bone marrow stroma (BMS) induces Jagged1 expression in bone metastatic prostate cancer PC3 cells and that this enhanced expression is mechanistically linked to the promotion of cell migration. We also show that RIP-generated Jagged1 fragments exert disparate effects on PC3 cell behaviour and Notch signaling. In conclusion, the expression of both the full-length ligand and its RIP-generated fragments must be considered in tandem when attempting to regulate Jagged1 as a possible PCa therapy

Studying and modeling of submerged aquatic vegetation environments seen by a single beam echosounder

International audienceFor both environmental and economic reasons, it is important to map the distribution of submerged aquatic vegetation. Acoustic technologies seem to be the more efficient and cost effective methods for that. Many papers have been published on underwater vegetation detection using an acoustic echo-sounder. However, few general studies have been performed to quantitatively understand the acoustic process of scattering from underwater vegetation. First, the effect of fields of vegetation on the temporal signal of the echo-sounder is studied. Real echo-sounder data obtained from different sites and different kinds of submerged aquatic vegetation was used. In most cases, the vegetation signal has a relatively strong backscatter signal before the bottom detection time and a less abrupt leading edge. However, different species-dependant behaviors were found. In order to explain this phenomenon and to characterize underwater vegetation, a model, based on the sonar equation, is developed to highlight the interaction between the acoustic wave and the environment composed of underwater vegetation. The result is a submerged aquatic vegetation apparent scattering index which can be used to help to characterize underwater vegetation

Drug and alcohol use as barriers to employment : a review of the literature

This report contains the findings of a literature review commissioned as part of a larger research project concerned with estimating the number of drug and alcohol users in private households in Britain and with identifying their barriers to work. The literature and programme review found few examples of employment service programmes for substance users and even fewer, which had been evaluated. All support programmes combined employment with treatment services, either through external linkages or internal provision. Successful programmes were found to have established a high level of inter-agency co-ordination, collaboration and communication, thus generating a climate of trust between support service providers as well as between providers and substance users. Employment service providers had in-depth knowledge of drug- or alcohol-related issues (health, behaviour etc.), as well as close links with the local labour market. Support for substance users involved one-to-one case management, continuity of support after placement, relapse prevention and referrals to other support services (e.g. benefits/financial; childcare; transport). Successful support dealt with a range of personal and perceptual problems that substance users articulated, including the risk of a profound distrust between users and support workers. Support work benefited from workers skilled in developing users’ social and communication skills as well as their confidence and assertiveness. Flexibility and diversity of support (e.g. financial advice) and the development of realistic short- and medium-term goals were critical to successful intervention. Organisational and spatially integrated provision of treatment and employment services appeared to increase the effectiveness of interventions providing they improved mutual understanding and the referral of substance users between task groups. Such integration enabled greater continuity of one-to-one support and thus improved the rapport between clients and service providers

Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signaling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells

A disintegrin and metalloproteinases (ADAMs) and matrix metalloproteinases (MMPs) are zinc metalloproteinases (ZMPs) that catalyse the 'ectodomain shedding' of a range of cell surface proteins including signalling and adhesion molecules. These 'sheddases' are associated with the invasion and metastasis of a range of cancers. Increased serum and tumour tissue levels of copper are also observed in several cancers although little is known about how the metal might promote disease progression at the molecular level. In the current study, we investigated whether copper might regulate the ectodomain shedding of two key cell surface proteins implicated in the invasion and metastasis of prostate cancer, the Notch ligand Jagged1 and the adhesion molecule E-cadherin, and whether the metal was able to influence the invasion of the prostate cancer epithelial cell line PC3. Physiological copper concentrations stimulated the ZMP-mediated proteolysis of Jagged1 and E-cadherin in cell culture models whilst other divalent metals had no effect. Copper-mediated Jagged1 proteolysis was also observed following the pre-treatment of cells with cycloheximide and in a cell-free membrane system, indicating a post-translational mechanism of sheddase activation. Finally, the concentrations of copper that stimulated ZMP-mediated protein shedding also enhanced PC3 invasion; an effect which could be negated using a sheddase inhibitor or copper chelators. Collectively, these data implicate copper as an important factor in promoting prostate cancer cell invasion and indicate that the selective post-translational activation of ZMP-mediated protein shedding might play a role in this process.

Multi-Industry Simplex : A Probabilistic Extension of GICS

Accurate industry classification is a critical tool for many asset management applications. While the current industry gold-standard GICS (Global Industry Classification Standard) has proven to be reliable and robust in many settings, it has limitations that cannot be ignored. Fundamentally, GICS is a single-industry model, in which every firm is assigned to exactly one group - regardless of how diversified that firm may be. This approach breaks down for large conglomerates like Amazon, which have risk exposure spread out across multiple sectors. We attempt to overcome these limitations by developing MIS (Multi-Industry Simplex), a probabilistic model that can flexibly assign a firm to as many industries as can be supported by the data. In particular, we utilize topic modeling, an natural language processing approach that utilizes business descriptions to extract and identify corresponding industries. Each identified industry comes with a relevance probability, allowing for high interpretability and easy auditing, circumventing the black-box nature of alternative machine learning approaches. We describe this model in detail and provide two use-cases that are relevant to asset management - thematic portfolios and nearest neighbor identification. While our approach has limitations of its own, we demonstrate the viability of probabilistic industry classification and hope to inspire future research in this field.Comment: 17 pages, 10 figure