Management of compressed gas cylinders in university laboratories

大学の安全管理上ならびに教職員・学生の健康障害防止上の観点からも，大学内の高圧ガスボンベの使用実態と作業環境を適切に把握し，管理することは重要な問題である。本研究では，大学における高圧ガスボンベの管理システムに関する課題とあり方について考察することを目的としている。高圧ガスボンベ管理の課題として，長期滞留ボンベの解決がある。課題解決の推進のために，新しい仕組みを導入し，管理方法を改善する取り組みを行った。新しい仕組みの導入に合わせて，共通仕様のタグの取り付けを検討した。共通仕様のタグの取り付けにより，効率良く学内の高圧ガスボンベ管理を行うことができると考えている。また，高圧ガスの取り扱いに関する教育コンテンツの充実を図り，より多くの教育を実践することが必要である。The purpose of this study was to perceive and to consider the management of compressed gas cylinders (CGC) in university laboratories. We examined the present conditions of CGC on campus, and pointed out the problems which should be improved. Cylinders were found to be preserved for an extended period of time. A new system was considered to propel this problem. Standardized tags were put on the CGCs to simplify management. There is also a need to educate students and staffs with enhanced educational material about CGC handling

Functional Food Targeting the Regulation of Obesity-Induced Inflammatory Responses and Pathologies

Obesity is associated with a low-grade systemic chronic inflammatory state, characterized by the abnormal production of pro- and anti-inflammatory adipocytokines. It has been found that immune cells such as macrophages can infiltrate adipose tissue and are responsible for the majority of inflammatory cytokine production. Obesity-induced inflammation is considered a potential mechanism linking obesity to its related pathologies, such as insulin resistance, cardiovascular diseases, type-2 diabetes, and some immune disorders. Therefore, targeting obesity-related inflammatory components may be a useful strategy to prevent or ameliorate the development of such obesity-related diseases. It has been shown that several food components can modulate inflammatory responses in adipose tissue via various mechanisms, some of which are dependent on peroxisome proliferator-activated receptor γ (PPARγ), whereas others are independent on PPARγ, by attenuating signals of nuclear factor-κB (NF-κB) and/or c-Jun amino-terminal kinase (JNK). In this review, we introduce the beneficial effects of anti-inflammatory phytochemicals that can help prevent obesity-induced inflammatory responses and pathologies

Associations between Dietary Patterns, ADRβ2 Gln27Glu and ADRβ3 Trp64Arg with Regard to Serum Triglyceride Levels : J-MICC Study

Interactions between dietary patterns and 2 β-adrenergic receptor (ADRβ) gene polymorphisms (ADRβ2 Gln27Glu and ADRβ3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35–69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADRβ3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADRβ polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADRβ3 polymorphism modifies the effects of the bread pattern on triglyceride levels

Simultaneous MITSuME gRI monitoring of S5 0716+714

We present results of our intra-night optical flux monitoring observations of S5 0716+714 done simultaneously in gRI filters. The observations were done using Multicolor Imaging Telescopes for Survey and Monstrous Explosions (MITSuME) instrument on the 50 cm telescope at the Okayama Astrophysical Observatory over 30 nights between 11 March 2008 and 8 May 2008. Of these 30 nights, 22 nights have continuous (without any break) observations with duration ranging from 1 to 6 hours and hence were considered for intra-night optical variability (INOV). In total we have 4888 datapoints which were simultaneous in gR and I filters. Of the 22 nights considered for INOV, the object showed flux variability on 19 nights with the amplitude of variability in the I-band ranging from ~4% to ~55%. The duty cycle for INOV was thus found to be 83%. No time lag between different bands was noticed on most of the nights, except for 3 nights where the variation in g was found to lead that of the I band by 0.3 to 1.5 hrs. On inter-night timescales, no lag was found between g and I bands. On inter-night timescales as well as intra-night timescales on most of the nights, the amplitude of variability was found to increase toward shorter wavelengths. The flux variations in the different bands were not achromatic, with the blazar tending to become bluer when brighter both on inter-night and intra-night timescales; and this might be attributed to the larger amplitude variation at shorter wavelengths. A clear periodic variation of 3.3 hrs was found on 1 April 2008 and a hint for another possible periodic variability of 4 hrs was found on 31 March 2008. During our 30 days of observations over a 2 month period the source has varied with an amplitude of variability as large as ~80%.Comment: 11 pages, 8 figures and 5 tables, Accepted in MNRA

Superhump Evolution in the Ultrashort Period Dwarf Nova 1RXS J232953.9+062814

Abstract We report on the evolution of superhumps and late superhumps in an ultrashort period dwarf nova, 1RXS J232953.9$+$062814, during the superoutburst in 2001 November. Ordinary superhumps were observed throughout a plateau phase, a rapid fading phase, and a rebrightening phase. During the plateau phase, the superhump period increased with time at a large rate of $P_\mathrm{dot} = 1.19 \pm 0.24 \times 10^{-4}$. In conjunction with the rebrightening phenomenon, these characteristics indicate that an accretion disk expanded further outward from the $3:1$ resonance radius, which caused a large amount of left over matter at the outer disk, even after the superoutburst. In the post-outburst phase, we detected late superhumps superimposed on dominant double-peak modulations. Late superhumps were observed at least for 10 d without a significant period change. We detected the first normal outburst of this object on 2001 December 26. The interval between the superoutburst and this normal one is 53 d. This short recurrence time supports a high mass-transfer rate in this system. Concerning the evolutionary status of 1RXS J232953.9$+$062814, we propose that it is a progenitor of AM CVn stars on the evolutionary course of the cataclysmic variable channel in which systems have a secondary star with a hydrogen-exhausted core

Multiple transcripts of Ca 2ϩ channel ␣ 1 -subunits and a novel spliced variant of the ␣ 1C -subunit in rat ductus arteriosus

3 H]thymidine incorporation, suggesting that L-and T-type Ca 2ϩ channels are involved in smooth muscle cell proliferation in the DA. Third, we found that a novel alternatively spliced variant of the ␣ 1C-isoform was highly expressed in the neointimal cushion of the DA, where proliferating and migrating smooth muscle cells are abundant. The basic channel properties of the spliced variant did not differ from those of the conventional ␣1C-subunit. We conclude that multiple VDCC subunits were identified in the DA, and, in particular, ␣ 1C-and ␣1G-subunits were predominant in the DA. A novel spliced variant of the ␣1C-subunit gene may play a distinct role in neointimal cushion formation in the DA. alternative spliced; development; gene expression; fetal circulation THE DUCTUS ARTERIOSUS (DA) is a fetal arterial connection between the pulmonary artery and the descending aorta. After birth, the DA closes immediately, in accordance with its smooth muscle contraction. An increase in oxygen tension and a dramatic decline in circulating prostaglandins are the most important triggers of DA contraction (5). Generally, vascular smooth muscle contraction is induced by Ca 2ϩ / calmodulin-dependent phosphorylation of the regulatory myosin light chain, which is mediated by an increase in intracellular Ca 2ϩ . Ca 2ϩ influx through voltage-dependent Ca 2ϩ channels (VDCCs) and Ca 2ϩ release from intracellular stores are major sources of this increase (8, 26). Thus VDCCs must play an important role in vascular myogenic reactivity and tone of the DA. VDCCs are classified, according to their distinct electrophysiological and pharmacological properties, into low (Ttype) and high (L-, N-, P-, Q-, and R-type) VDCCs (20, In addition to their role in determining contractile state, a growing body of evidence has demonstrated that VDCCs play an important role in regulating differentiation and remodeling of vascular smooth muscle cells (SMCs) (14, In the present study, we identified multiple VDCC subunits in the DA by semiquantitative and quantitative RT-PCR and immunodetection. In particular, ␣ 1C -and ␣ 1G -subunits were predominant in the DA. Furthermore, we will demonstrate the identification of a novel spliced variant of the ␣ 1C -subunit gene that may play a role in neointimal cushion formation of the DA

Des-γ-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma

Abstract Background and Aims

A Multicenter Phase 2 Trial Evaluating the Efficacy and Safety of Preoperative Lenvatinib Therapy for Patients with Advanced Hepatocellular Carcinoma (LENS-HCC Trial)

Introduction: The phase III REFLECT trial demonstrated that lenvatinib was superior to sorafenib in terms of progression-free survival (PFS), time to progression, and objective response rate (ORR) for patients with unresectable hepatocellular carcinoma (HCC). This study assessed the efficacy and safety of preoperative lenvatinib therapy for patients with oncologically or technically unresectable HCC. Methods: In this multicenter single-arm phase II trial, patients with advanced HCC and factors suggestive of a poor prognosis (macroscopic vascular invasion, extrahepatic metastasis, or multinodular tumors) were enrolled. Patients with these factors, even with technically resectable HCC, were defined as oncologically unresectable because of the expected poor prognosis after surgery. After 8 weeks of lenvatinib therapy, the patients were assessed for resectability, and tumor resection was performed if the tumor was considered technically resectable. The primary endpoint was the surgical resection rate. The secondary endpoints were the macroscopic curative resection rate, overall survival (OS), ORR, PFS, and the change in the indocyanine green retention rate at 15 min as measured before and after lenvatinib therapy. The trial was registered with the Japan Registry of Clinical Trials (s031190057). Results: Between July 2019 and January 2021, 49 patients (42 oncologically unresectable patients and 7 technically unresectable patients) from 11 centers were enrolled. The ORR was 37.5% based on mRECIST and 12.5% based on RECIST version 1.1. Thirty-three patients underwent surgery (surgical resection rate: 67.3%) without perioperative mortality. The surgical resection rate was 76.2% for oncologically unresectable patients and 14.3% for technically unresectable patients. The 1-year OS rate and median PFS were 75.9% and 7.2 months, respectively, with a median follow-up period of 9.3 months. Conclusions: The relatively high surgical resection rate seen in this study suggests the safety and feasibility of lenvatinib therapy followed by surgical resection for patients with oncologically or technically unresectable HCC

Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae

We systematically surveyed period variations of superhumps in SU UMa-type dwarf novae based on newly obtained data and past publications. In many systems, the evolution of superhump period are found to be composed of three distinct stages: early evolutionary stage with a longer superhump period, middle stage with systematically varying periods, final stage with a shorter, stable superhump period. During the middle stage, many systems with superhump periods less than 0.08 d show positive period derivatives. Contrary to the earlier claim, we found no clear evidence for variation of period derivatives between superoutburst of the same object. We present an interpretation that the lengthening of the superhump period is a result of outward propagation of the eccentricity wave and is limited by the radius near the tidal truncation. We interpret that late stage superhumps are rejuvenized excitation of 3:1 resonance when the superhumps in the outer disk is effectively quenched. Many of WZ Sge-type dwarf novae showed long-enduring superhumps during the post-superoutburst stage having periods longer than those during the main superoutburst. The period derivatives in WZ Sge-type dwarf novae are found to be strongly correlated with the fractional superhump excess, or consequently, mass ratio. WZ Sge-type dwarf novae with a long-lasting rebrightening or with multiple rebrightenings tend to have smaller period derivatives and are excellent candidate for the systems around or after the period minimum of evolution of cataclysmic variables (abridged).Comment: 239 pages, 225 figures, PASJ accepte