The suppression of DNA repair induced by PARP-1 inhibitors rucaparib and olaparib in combination with the radiopharmaceutical 131I-MIBG in noradrenaline transporter-expressing xenograft tumors

No abstract available

Biological vulnerability to depression: Linked structural and functional brain network findings

Background: Patients in recovery following episodes of major depressive disorder (MDD) remain highly vulnerable to future recurrence. Although psychological determinants of this risk are well established, little is known about associated biological mechanisms. Recent work has implicated the default mode network (DMN) in this vulnerability but specific hypotheses remain untested within the high risk, recovered state of MDD. Aims: To test the hypothesis that there is excessive DMN functional connectivity during task performance within recovered-state MDD and to test for connected DMN cortical gyrification abnormalities. Method: A multimodal structural and functional magnetic resonance imaging (fMRI) study, including task-based functional connectivity and cortical folding analysis, comparing 20 recoveredstate patients with MDD with 20 matched healthy controls. Results: The MDD group showed significant task-based DMN hyperconnectivity, associated with hypogyrification of key DMN regions (bilateral precuneus). Conclusions: This is the first evidence of connected structural and functional DMN abnormalities in recovered-state MDD, supporting recent hypotheses on biological-level vulnerability

Plant cover, soil temperature, freeze, water stress, and evapotranspiration conditions

There are no author-identified significant results in this report

Plant cover, soil temperature, freeze, water stress, and evapotranspiration conditions

There are no author-identified significant results in this report

AgRISTARS: Early warning and crop condition assessment. Plant cover, soil temperature, freeze, water stress, and evapotranspiration conditions

Emissive (10.5 to 12.5 microns) and reflective (0.55 to 1.1 microns) data for ten day scenes and infrared data for six night scenes of southern Texas were analyzed for plant cover, soil temperature, freeze, water stress, and evapotranspiration. Heat capacity mapping mission radiometric temperatures were: within 2 C of dewpoint temperatures, significantly correlated with variables important in evapotranspiration, and related to freeze severity and planting depth soil temperatures

Plant cover, soil temperature, freeze, water stress, and evapotranspiration conditions

There are no author-identified significant results in this report

Plant cover, soil temperature, freeze, water stress, and evapotranspiration conditions

The author has identified the following significant results. HCMM day/night coverage 12 hours apart cannot be obtained at 26 deg N latitude; nor have any pairs 36 hours apart been obtained. A day-IR scene and a night scene for two different dates were analyzed. A profile across the test site for the same latitude shows that the two profiles are near mirror images of each other over land surfaces and that the temperature of two large water bodies, Falcon Reservoir and the Gulf of Mexico, are nearly identical on two dates. During the time interval between overpasses, the vegetative cover remained static due to winter dormancy. The data suggest that day/night temperature differences measured weeks apart may yield meaningful information about the contrast between daytime maximum and nighttime minimum temperatures for a given site

Plant cover, soil temperature, freeze, water stress, and evapotranspiration conditions

The author has identified the following significant results. Procedures to edit cloud-contaminated pixels from those pixels representing Earth surface features were investigated. Because clouds are more reflective than Earth features and are colder than Earth surface features most of the year at 26 N latitude, either a raw digital count ratio or a ratio of reflectance percentage for the VIS band to the temperature works well. For this procedure, the two bands of data need to be registered to the ground scene

Plant cover, soil temperature, freeze, water stress, and evapotranspiration

There are no author-identified significant results in this report

Plant cover, soil temperature, freeze, water stress, and evapotranspiration conditions

Emissive and reflective data for 10 days, and IR data for 6 nights in south Texas scenes were analyzed after procedures were developed for removing cloud-affected data. HCMM radiometric temperatures were: within 2 C of dewpoint temperatures on nights when air temperature approached dewpoint temperatures; significantly correlated with variables important in evapotranspiration; and, related to freeze severity and planting depth soil temperatures. Vegetation greenness indexes calculated from visible and reflective IR bands of NOAA-6 to -9 meteorological satellites will be useful in the AgRISTARS program for seasonal crop development, crop condition, and drought applications