An interesting case of metastatic brain abscess

Klebsiella pneumoniae is a Gram-negative, non-motile, lactose fermenting, aerobic rod-shaped bacterium with three different subspecies, K. pneumoniae, Klebsiella ozaenae, and Klebsiella rhinoscleromatis. Here, we report the case of a 32-year-old male, chronic alcoholic presented with fever, hemoptysis, and headache of 20 days duration. Over a period of 4 days, the patient worsened with the development of altered sensorium and respiratory distress, connected to a mechanical ventilator. Computed tomography and chest X-ray showed consolidation involving the left lower lobe with an air-fluid level. Magnetic resonance imaging brain showed multiple metastatic brain abscess involving cerebrum and cerebellum and culture reports of sputum and blood showed K. pneumoniae. The patient was started on antibiotics along with anti-tubercular drugs. In spite of effective management, the patient developed recurrent episodes of hemoptysis and died of respiratory failure. For the concomitant involvement of both cerebrum and cerebellum for the first time

Vanishing headache in a young female: An interesting case report

Headache is one of the most common neurological symptom occurring worldwide. Here, we present a unique case of secondary headache in a young female which got reversed with appropriate treatment. A young female who presented with a severe subacute unilateral left-sided intractable headache with papilledema and obstructive hydrocephalus was found to have 4th ventricular neurocysticercosis causing obstruction of the foramen of Magendi and Luschka, relieved on timely surgical excision and with medical management. This case is reported to highlight the rare causes of secondary headache and various presentations of neurocysticercosis, in endemic areas like India as it causes neurological morbidity which can be alleviated on appropriate treatment, thereby preventing economic hardship and improving the quality of life

ANTIOXIDANT POTENTIAL OF MALAYSIAN FRUIT EXTRACT (MYRISTICA FRAGRANS)

The aim of this experiment is to study the phytochemical content of Malaysian fruit (Myristica fragrans), commonly known as nutmeg. This study also includes the optimization of extraction conditions for both soxhlet and ultrasonic extraction to yield the highest total phenolic content, total flavonoid content and 2, 2-diphenyl picryl hydrazyl scavenging activity of nutmegs using Response surface methodology. Soxhlet extraction is carried out with different extraction time and type of solvent. However, ultrasonic-assisted extraction is carried out with different extraction time, concentration of solvent and temperature of ultrasonic water bath. It has been shown that the optimum value of total phenolic content, total flavonoid content and 2, 2-diphenyl picryl hydrazyl scavenging activity of soxhlet extraction on nutmegs are 12.290 mg, 17.09 mg and 95.837%, respectively with a desirability of 0.671. The optimum condition for soxhlet extraction of nutmegs to obtain optimum yield of total phenolic content, total flavonoid content and 2, 2-diphenyl picryl hydrazyl scavenging are by using methanol as solvent at 184 minutes extraction time. However, for the optimization value of total phenolic content, total flavonoid content and 2, 2- diphenyl picryl hydrazyl scavenging activity for ultrasonic- assisted extraction of nutmegs are 28.722 mg, 46.600 mg and 98.565%, respectively with a desirability of 0.977. The optimum condition for ultrasonic assisted extraction of nutmegs to obtain optimum yield of total phenolic content, total flavonoid content and 2, 2- diphenyl picryl hydrazyl scavenging are by extracting nutmeg at 40 minutes at 50 ℃ and at 40% ethanol concentration

Plasmablastic lymphoma mimicking orbital cellulitis

Introduction Orbital cellulitis is an uncommon, potentially devastating condition that, when not promptly and adequately treated, can lead to serious sequelae. The presenting clinical signs are proptosis, swelling, ophthalmoplegia, pain and redness of the peri-orbital tissues. A number of case

Charge and discharge behavior of elemental sulfur in isochoric high temperature thermal energy storage systems

Thermal energy storage with elemental sulfur is a low-cost alternative to molten salts for many medium to high-temperature energy applications (200–600 °C). In this effort, by examining elemental sulfur stored isochorically inside isolated pipes, we find that sulfur provides attractive charge/discharge performance since it operates in the liquid-vapor regime at the temperatures relevant to many important applications, such as combined heat and power (CHP) plants and concentrating solar power (CSP) plants with advanced power cycle systems. The isolated pipe configuration is relevant to shell-and-tube thermal battery applications where the heat transfer fluid flows over the storage pipes through the shell. We analyze the transient charge and discharge behavior of sulfur inside the pipes using detailed computational modeling of the complex conjugate heat transfer and fluid flow phenomena. The computational model is validated against experiments of a single tube with well-defined temperature boundary conditions and internal temperature measurements. The model results evaluate the influence of pipe diameter on charge and discharge times, heat transfer rate, and Nusselt number due to buoyancy driven convection currents. Depending on the Rayleigh number (pipe diameter), the average Nusselt number obtained for discharge is 3–14 times higher than proposed solid-liquid phase change technologies based on molten salt, which are limited in their performance due to conduction based solidification and low thermal conductivity. The results show competing trade-offs between increase in heat transfer coefficient, thermal energy stored in sulfur, and increase in charge and discharge time with increase in pipe diameter. A preferred pipe diameter can be determined for target applications based on their requirements and these competing trade-offs. A validated fundamental correlation for Nusselt number as a function of Rayleigh number for charge and discharge is developed that can be used to design the sulfur-based thermal storage system for transient operation

Charge and discharge behavior of elemental sulfur in isochoric high temperature thermal energy storage systems

Thermal energy storage with elemental sulfur is a low-cost alternative to molten salts for many medium to high-temperature energy applications (200–600 °C). In this effort, by examining elemental sulfur stored isochorically inside isolated pipes, we find that sulfur provides attractive charge/discharge performance since it operates in the liquid-vapor regime at the temperatures relevant to many important applications, such as combined heat and power (CHP) plants and concentrating solar power (CSP) plants with advanced power cycle systems. The isolated pipe configuration is relevant to shell-and-tube thermal battery applications where the heat transfer fluid flows over the storage pipes through the shell. We analyze the transient charge and discharge behavior of sulfur inside the pipes using detailed computational modeling of the complex conjugate heat transfer and fluid flow phenomena. The computational model is validated against experiments of a single tube with well-defined temperature boundary conditions and internal temperature measurements. The model results evaluate the influence of pipe diameter on charge and discharge times, heat transfer rate, and Nusselt number due to buoyancy driven convection currents. Depending on the Rayleigh number (pipe diameter), the average Nusselt number obtained for discharge is 3–14 times higher than proposed solid-liquid phase change technologies based on molten salt, which are limited in their performance due to conduction based solidification and low thermal conductivity. The results show competing trade-offs between increase in heat transfer coefficient, thermal energy stored in sulfur, and increase in charge and discharge time with increase in pipe diameter. A preferred pipe diameter can be determined for target applications based on their requirements and these competing trade-offs. A validated fundamental correlation for Nusselt number as a function of Rayleigh number for charge and discharge is developed that can be used to design the sulfur-based thermal storage system for transient operation