Propuesta de modelo de vivienda flotante de un piso, como solución a la problemática por inundación en el barrio Villa Juliana, localizada en el municipio de Cartago - Valle del Cauca

CD-T 728.78 P21;150 p.Propuesta de un modelo de vivienda que resiste inundaciones para la problemática que se presenta en temporadas de invierno en Cartago Valle del Cauca. La propuesta consiste en definir los materiales adecuados para el sistema construtivo de la vivienda, proponer una estructura que permita la flotabilidad teniendo en cuenta que cambia de nivel dependiendo de la cota de inundación, determinar los costos de producción del modelo y realizar apropiados diseños como: arquitectónico, estructural y de flotación adaptados al barrio Villa Juliana de Cartago Valle del Cauca.Universidad Libre Seccional Pereir

GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm.

In vertebrates, GATA2 is a master regulator of hematopoiesis and is expressed throughout embryo development and in adult life. Although the essential role of GATA2 in mouse hematopoiesis is well established, its involvement during early human hematopoietic development is not clear. By combining time-controlled overexpression of GATA2 with genetic knockout experiments, we found that GATA2, at the mesoderm specification stage, promotes the generation of hemogenic endothelial progenitors and their further differentiation to hematopoietic progenitor cells, and negatively regulates cardiac differentiation. Surprisingly, genome-wide transcriptional and chromatin immunoprecipitation analysis showed that GATA2 bound to regulatory regions, and repressed the expression of cardiac development-related genes. Moreover, genes important for hematopoietic differentiation were upregulated by GATA2 in a mostly indirect manner. Collectively, our data reveal a hitherto unrecognized role of GATA2 as a repressor of cardiac fates, and highlight the importance of coordinating the specification and repression of alternative cell fates.Ramón y Cajal Program, Spanish Ministry of Economy, Industry, and Competitiveness, Spanish Cancer Association, FERO, Instituto de Salud Carlos III, European Social Fund, MINECO, PERIS Program of the Generalitat de Catalunya, Obra Social la Caixa-Fundacion Josep Carreras, Spanish Institute of Health Carlos III, Wellcome Trust, MRC, CRUK, NIH-NIDD

Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre

We provide an updated assessment of the power of the Cherenkov Telescope Array (CTA) to search for thermally produced dark matter at the TeV scale, via the associated gamma-ray signal from pair-annihilating dark matter particles in the region around the Galactic centre. We find that CTA will open a new window of discovery potential, significantly extending the range of robustly testable models given a standard cuspy profile of the dark matter density distribution. Importantly, even for a cored profile, the projected sensitivity of CTA will be sufficient to probe various well-motivated models of thermally produced dark matter at the TeV scale. This is due to CTA's unprecedented sensitivity, angular and energy resolutions, and the planned observational strategy. The survey of the inner Galaxy will cover a much larger region than corresponding previous observational campaigns with imaging atmospheric Cherenkov telescopes. CTA will map with unprecedented precision the large-scale diffuse emission in high-energy gamma rays, constituting a background for dark matter searches for which we adopt state-of-the-art models based on current data. Throughout our analysis, we use up-to-date event reconstruction Monte Carlo tools developed by the CTA consortium, and pay special attention to quantifying the level of instrumental systematic uncertainties, as well as background template systematic errors, required to probe thermally produced dark matter at these energies

Actualización e internacionalización del catálogo "OSCAR" de experiencias de Física General

En convocatorias anteriores de la convocatorias de Proyectos de Innovación Docente de l UCM, la última de ellas correspondiente a 2014, desarrollamos un Catálogo de experiencias de cátedra para la docencia de Física General, OSCAR. En esta edición los hemos ampliado con nuevas experiencias. Asimismo se ha desarrollado un programa de visitas de colegios a la Facultad de Ciencias Físicas de la UCM

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Dark Matter constrains from high energy astrophysical observations

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Físicas, leída el 28/02/2012. Textos en inglés y español.Depto. de Estructura de la Materia, Física Térmica y ElectrónicaFac. de Ciencias FísicasTRUEunpu

Direct measurement of stellar angular diameters by the VERITAS Cherenkov telescopes

Artículo firmado por más de 10 autores.The angular size of a star is a critical factor in determining its basic properties. Direct measurement of stellar angular diameters is difficult: at interstellar distances stars are generally too small to resolve by any individual imaging telescope. This fundamental limitation can be overcome by studying the diffraction pattern in the shadow cast when an asteroid occults a star, but only when the photometric uncertainty is smaller than the noise added by atmospheric scintillation. Atmospheric Cherenkov telescopes used for particle astrophysics observations have not generally been exploited for optical astronomy due to the modest optical quality of the mirror surface. However, their large mirror area makes them well suited for such high-time-resolution precision photometry measurements. Here we report two occultations of stars observed by the VERITAS Cherenkov telescopes with millisecond sampling, from which we are able to provide a direct measurement of the occulted stars’ angular diameter at the _ 0:1 milliarcsecond scale. This is a resolution never achieved before with optical measurements and represents an order of magnitude improvement over the equivalent lunar occultation method. We compare the resulting stellar radius with empirically derived estimates from temperature and brightness measurements, confirming the latter can be biased for stars with ambiguous stellar classifications.United States Department of EnergyNational Science Foundation (United States)Smithsonian InstitutionNatural Sciences and Engineering Research Council of CanadaHelmholtz AssociationDepto. de Estructura de la Materia, Física Térmica y ElectrónicaFac. de Ciencias FísicasInstituto de Física de Partículas y del Cosmos (IPARCOS)TRUEpu

“Identificación de la prevalencia del riesgo de los Administrativos de la Universidad del Quindío de desarrollar diabetes aplicando la escala FINDRISK”

En Colombia, según datos de la Organización Mundial de la Salud (OMS) para el año 2016, se reportaron 2670 fallecimientos asociados a complicaciones causadas por la diabetes, siendo las mujeres las principales afectadas con una mayor prevalencia . Para el departamento del Quindío, no se han realizado estudios significativos que muestren el comportamiento de esta enfermedad sobre la población en general. La DM no solo afecta el estado de glucosa en sangre, también genera un impacto en la calidad de vida de las personas con una serie de complicaciones que conllevan a un deterioro físico, social y mental como lo engloba la OMS en su concepto de salud. Las personas que padecen de DM corren un riesgo mayor de desarrollar enfermedad periodontal, una probabilidad entre 2 y 3 veces mayor de tener enfermedades cardiovasculares, un riesgo 10 veces más alto de desarrollar enfermedad renal terminal y un tercio de estos pacientes terminarán con una retinopatía diabética, cada 30 segundos un diabético pierde su extremidad inferior total o parcialmente; lo que conlleva a una afectación emocional, laboral y social de estas personas. Según Kaan et al. La DM en las personas jóvenes de edad productiva es cada vez más común, y sus complicaciones representan causas de bajas laborales o incapacidades, además de disminución de la productividad. Además, se ha encontrado que en algunos sitios evitan contratar personas que cursan con diabetes en trabajo que implican riesgos debido a la probabilidad de cursar con hipoglicemia o por el ideal de que trabajan poco debido a su enfermedad . Lo anterior, es solo una pequeña muestra de las repercusiones que puede tener una enfermedad crónica, sobre todo si cursa con complicaciones.EpidemiológicaSalud Labora

vFAB: Facilitando el método de clase invertida mediante la producción de material audiovisual aplicado a los seminarios de Física Aplicada a la Biología (II)

Depto. de Estructura de la Materia, Física Térmica y ElectrónicaFac. de Ciencias FísicasFALSEsubmitte