14 research outputs found
ΠΠ°ΡΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΡΠΈ ΠΏΡΠΎΡΡΠ°ΡΠΈΡΠ΅/ΡΠΈΠ½Π΄ΡΠΎΠΌΠ΅ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΎΠ»ΠΈ
ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π½Π΅Π»Π΅ΡΠ΅Π½Π½ΠΎΠ΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠΏΠ΅ΡΠΌΠΎΠ³ΡΠ°ΠΌΠΌΡ ΠΈ Π² ΡΡΠ΄Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΠΊ Π±Π΅ΡΠΏΠ»ΠΎΠ΄ΠΈΡ ΠΏΡΠΈ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΏΠΎΠ»ΠΎΠ²ΡΡ
ΠΆΠ΅Π»Π΅Π· ΠΈ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΌ Π³ΠΎΡΠΌΠΎΠ½Π°Π»ΡΠ½ΠΎΠΌ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°. ΠΠ°ΠΊΡΠ΅ΡΠΈΠΈ, Π²ΠΈΡΡΡΡ, Π»Π΅ΠΉΠΊΠΎΡΠΈΡΡ, ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΠ΅ ΡΠ°Π΄ΠΈΠΊΠ°Π»Ρ, ΡΠΈΡΠΎΠΊΠΈΠ½Ρ, ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΡ ΡΠ΅ΠΌΡΠ²ΡΠ²ΠΎΠ΄ΡΡΠΈΡ
ΠΏΡΡΠ΅ΠΉ ΠΏΡΠΈ ΠΏΡΠΎΡΡΠ°ΡΠ΅ ΡΠ²Π»ΡΡΡΡΡ ΠΊΠΎΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π±Π΅ΡΠΏΠ»ΠΎΠ΄ΠΈΡ.It is shown that untreated chronic inflammation of the prostate gland causes disturbances of spermogram count and strility in a number of cases at normal development of sex glands and sufficient hormone supply of the organism. Bacteria, viruses, leukocytes, free radicals, cytokines, immunological changes and obstruction of the deferent ducts in prostatitis are coβfactors of sterility development
ΠΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ Π²Π°Π»ΡΠΏΡΠΎΡΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Ρ ΠΊΡΠΎΠ²Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π°ΠΊΡΡΠΉΠ½ΠΎΡ Π²ΠΈΡΠΎΠΊΠΎΠ΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡ ΡΡΠ΄ΠΈΠ½Π½ΠΎΡ Ρ ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΡΡ
ΠΠ΄ΡΠΉΡΠ½Π΅Π½Π° Π²Π·Π°ΡΠΌΠΎΠ΄ΡΡ Π²Π°Π»ΡΠΏΡΠΎΡΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ Π· 3-(2'-Π±ΡΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ»)-7-ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΡΠΌΠ°ΡΠΈΠ½ΠΎΠΌ Ρ ΡΠΎΠ·ΡΠΎΠ±Π»Π΅Π½ΠΎ ΡΡ Π²ΠΈΠ·Π½Π°ΡΠ΅Π½Π½Ρ Ρ ΠΊΡΠΎΠ²Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π°ΠΊΡΡΠΉΠ½ΠΎΡ Π²ΠΈΡΠΎΠΊΠΎΠ΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡ ΡΡΠ΄ΠΈΠ½Π½ΠΎΡ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΡΡ. ΠΠΈΠ²ΡΠ΅Π½ΠΈΠΉ Π²ΠΏΠ»ΠΈΠ² ΡΡΠ·Π½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ² Π΄Π΅ΠΏΡΠΎΡΠΎΡΠ½ΡΠ·Π°ΡΡΡ Π½Π° Π²ΠΈΠ²ΡΠ»ΡΠ½Π΅Π½Π½Ρ Π²Π°Π»ΡΠΏΡΠΎΡΠ²ΠΎΡ ΠΊΠΈΡΠ»ΠΎΡΠΈ ΡΠ° ΠΎΠΏΡΠΈΠΌΡΠ·ΠΎΠ²Π°Π½Ρ ΡΠΌΠΎΠ²ΠΈ ΠΏΡΠΎΠ±ΠΎΠΏΡΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ.ΠΡΡΡΠ΅ΡΡΠ²Π»Π΅Π½ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π²Π°Π»ΡΠΏΡΠΎΠ΅Π²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Ρ 3-(2'-Π±ΡΠΎΠΌΠ°ΡΠ΅ΡΠΈΠ»)-7-ΠΌΠ΅ΡΠΎΠΊΡΠΈΠΊΡΠΌΠ°ΡΠΈΠ½ΠΎΠΌ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ΠΎ Π΅Π΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π² ΠΊΡΠΎΠ²ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΉ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ. ΠΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄Π΅ΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΈΠ·Π°ΡΠΈΠΈ Π½Π° Π²ΡΡ
ΠΎΠ΄Ρ Π²Π°Π»ΡΠΏΡΠΎΠ΅Π²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΈ ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΏΡΠΎΠ±ΠΎΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ.The interaction of the valproic acid with 3-(2'-bromoacetyl)-7-methoxicoumarin has been carried out and its determination in blood by the reaction high performance liquid chromatography method has been developed. The influence of various methods of deproteinization on the yields of the valproic acid has been studied and the conditions of the sample preparing has been optimized
ΠΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π³Π΅ΡΡΠ°Π³Π΅Π½/ΡΡΡΡΠΎΠ³Π΅Π½Π½ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π³ΠΈΠΏΠ΅ΡΠ°Π½Π΄ΡΠΎΠ³Π΅Π½ΠΈΠΈ
Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³Π΅ΡΡΠ°Π³Π΅Π½/ΡΡΡΡΠΎΠ³Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Π³ΠΈΠΏΠ΅ΡΠ°Π½Π΄ΡΠΎΠ³Π΅Π½ΠΈΠΈ. ΠΠΏΠΈΡΠ°Π½Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ Π΄ΡΠΎΡΠΏΠΈΡΠ΅Π½ΠΎΠ½Π° Ρ ΡΡΠΈΠ½ΠΈΠ΄ΡΡΡΡΠ°Π΄ΠΈΠΎΠ»ΠΎΠΌ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ Π°ΠΊΠ½Π΅, ΡΠ΅Π±ΠΎΡΠ΅ΠΈ ΠΈ Π³ΠΈΡΡΡΡΠΈΠ·ΠΌΠ° Ρ ΠΆΠ΅Π½ΡΠΈΠ½, ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ Π½ΡΠΆΠ΄Π°ΡΡΠΈΡ
ΡΡ Π² ΠΊΠΎΠ½ΡΡΠ°ΡΠ΅ΠΏΡΠΈΠΈ.The biochemical mechanisms of action of gestagen/estrogen drugs in treatment for syndrome of hyperandrogeny are featured. The advantages of Drospirenon and Etinidestradiol combination in treatment of acne, seborrhea and hirsutism in women simultaneously requiring contraception are described
Regenerative medicine interventions for orthopedic disorders: ethical issues in the translation into patients
Regenerative medicine (RM) technologies, such as cell therapy, gene transfer and tissue engineering, are expected to move the field of orthopedics into a new era. Now that more and more attempts are underway to translate preclinical research into clinical studies, it is time to proactively discuss the ethical issues associated with first-in-human applications of RM interventions for musculoskeletal disorders. The design and launch of early clinical trials will be ethically challenging due to the specific features of RM in general, and the application for musculoskeletal disorders specifically. In this paper, we identify three sets of ethical issues that need to be addressed when considering initiating early clinical trials: assessment of risks and benefits; designing a study in terms of outcome measures and comparators; and participant selection. These issues are particularly emphasized in RM research that aims to apply these approaches in an early stage of degenerative musculoskeletal disorders
Reconsidering the ethics of sham interventions in an era of emerging technologies
Background. Our aim was to ethically evaluate the arguments in favor and against sham interventions, as presented in literature. Two developments underscore the need to reconsider the ethics of sham interventions. First, the number of clinical trials investigating interventions in the field of regenerative medicine are increasing, in which the choice for a placebo requires an invasive intervention. Second, the increased awareness of the lack of systematic research in surgery stresses the need to discuss the necessity and acceptability of sham-controlled clinical trials. Methods. A systematic search in Medline was performed, of which 104 articles were considered relevant. Results. Arguments in favor of a sham controlled design are that it increases the scientific validity and the benefits to society while at the same time the risks and harm can be acceptable. Arguments against sham controls include that they pose unacceptable risks to participants, present difficulties with informed consent, that the use of deceptive tactics is unethical, and that the feasibility of such controls is compromised because of a lack of public support. Conclusion. None of the published literature fully rejects sham interventions, and many regard sham interventions acceptable provided the conditions of scientific necessity, reasonable risks, and valid informed consent are fulfilled. Further debate should no longer address whether a sham control is ethically acceptable but rather when these conditions are fulfilled
Societal impacts of regenerative medicine : reflections on the views of orthopedic professionals
As the amount of clinical studies in orthopedic regenerative medicine (RM) is increasing, it is time to take into account its impact on society. A total of 36 biomedical professionals working at the front row of orthopedic RM were interviewed to explore their attitudes, opinions and expectations regarding the societal impacts of RM. Professionals mainly recognized the societal impacts of counteraction of aging, prevention of disease and social justice. The 'soft' sides of these impacts were hardly mentioned. Whereas they did not perceive themselves in the position to mitigate these impacts, professionals should take up their role as actor and become involved in the societal debate. This is important as they can co-shape the societal impacts during the developmental process of technologies and thereby stimulate responsible innovation