Volume of distribution model for¹⁸F-TPP⁺ in a PET image voxel.

<p>The outer black line represents the voxel boundary. C_p, C_inter, C_cyto, and C_mito represent the concentrations of the plasma, interstitial space, cytosol, and mitochondria respectively. The arrows represent ¹⁸F-TPP⁺ transport between the different compartments. <i>f</i>_ECS represents the voxel volume fraction occupied by ECS and <i>f</i>_mito represents the cellular volume fraction occupied by mitochondria.</p

Comparison of <i>ΔΨ</i>_<i>T</i> in 17 "bull’s eye" segments Results shown for five control (blue squares) and three pigs with injury to the LAD territory (red circles).

<p>Comparison of <i>ΔΨ</i>_<i>T</i> in 17 "bull’s eye" segments Results shown for five control (blue squares) and three pigs with injury to the LAD territory (red circles).</p

Typical ¹⁸F-TPP⁺ SUV image, integrated from 60–120 minutes after IV bolus injection.

<p>SUV is highest in liver, followed by LV myocardium, with lower activity in the visible in bone marrow.</p

Dependence of <i>V</i>_<i>T</i> on mitochondrial membrane potential and fractional ECS computed with Eq 3.

<p><i>ΔΨ</i>_<i>T</i> is more negative inside membranes. Black lines indicate variation (systematic error) in <i>ΔΨ</i>_<i>T</i> range at constant volume of distribution due to neglecting fractional ECS volume.</p

Parametric images of V_T and ΔΨ_T.

<p>Each panel of three x two images shows short axis, vertical and horizontal slices. Images of a representative control pig are shown in the left panel. Images of a representative scar pig are shown in the right panel. The top row of each panel depicts the TPP⁺ volume of distribution and bottom row the membrane potential.</p

Measured values of mitochondrial membrane potential (milliVolts).

<p>Measured values of mitochondrial membrane potential (milliVolts).</p

Whole blood-to-plasma concentration ratio measured as a function of time after bolus injection of ¹⁸F-TPP⁺.

<p>After about 15 minutes, whole blood and plasma concentrations equilibrate with equal concentration.</p