Expression levels of TLR2 and TLR4 on monocytes (A) and granulocytes (B) FFR-positive and FFR-negative patients and healthy control subjects.

<p>*Comparison by Kruskal-Wallis test for all groups.** Between subgroups with Mann Whitney U test. TLR = toll-like receptor.</p

Baseline Characteristics of patients with stable angina.

<p> <i>Continuous values are presented as means ± standard deviation (SD). Categorical values are presented as number (percentages).</i></p>*<p> <i>Significance level 0.05. FFR = fractional flow reserve BMI = body mass index ;DM = diabetes mellitus; MI = myocardial infarction; PCI = percutaneous coronary intervention; CABG = coronary artery bypass grafting; LVEF = left ventricular ejection fraction.</i></p>**<p> <i>Defined as a serum creatinin >150 µmol/l.</i></p

Concentrations of cytokines and surface markers on monocytes and granulocytes according to FSS tertiles and FFR-negative patients.

<p>Concentrations of cytokines (A) and surface markers on monocytes (B) and granulocytes (C) according to FSS tertiles (of FFR-positive patients) and FFR-negative patients. Comparison of all subgroups was performed with the Jonckheere-Terpstra test. FSS = functional syntax score.</p

Comparison of levels of cytokines for FFR-positive and FFR-negative patients and healthy controls.

<p>*Comparison by Kruskal-Wallis test.** Between subgroup differences compared with Mann Whitney U test.</p

Medication use of patients with stable angina at inclusion.

<p> <i>Proportions were compared using Chi-square testing.</i></p>*<p> <i>Significance level 0.05. FFR = fractional flow reserve; ASA = Acetylsalicylic acid; ACE = angiotensin-converting enzyme.</i></p

Cumulative expression of P-selectin after stimulation with ADP (A), TRAP (B), CRP (C) and Iloprost with substimulatory ADP (D). Lines indicate median values with interquartile range.

<p>Cumulative expression of P-selectin after stimulation with ADP (A), TRAP (B), CRP (C) and Iloprost with substimulatory ADP (D). Lines indicate median values with interquartile range.</p

Maximal expression of P-selectin after stimulation with ADP (A), TRAP (B), CRP (C) and Iloprost with substimulatory ADP (D). Lines indicate median values with interquartile range.

<p>Maximal expression of P-selectin after stimulation with ADP (A), TRAP (B), CRP (C) and Iloprost with substimulatory ADP (D). Lines indicate median values with interquartile range.</p

Percentages of platelet-monocyte (A) and platelet-neutrophile (B) complexes in FFR-negative and FFR-positive patients, identified by presence of platelet marker CD42b on monocytes and neutrophils. Lines indicate median values with interquartile range.

<p>Percentages of platelet-monocyte (A) and platelet-neutrophile (B) complexes in FFR-negative and FFR-positive patients, identified by presence of platelet marker CD42b on monocytes and neutrophils. Lines indicate median values with interquartile range.</p

Platelets per monocyte (A) and neutrophil (B) measured by MFI of CD42b. Lines indicate median values with interquartile range.

<p>Platelets per monocyte (A) and neutrophil (B) measured by MFI of CD42b. Lines indicate median values with interquartile range.</p

Conversion of dose-response curve into area under the curve.

<p>In order to compare total platelet reactivity between patients, we derived the area under the curve from each dose response curve. MFI = mean fluorescence intensity, AUC = area under curve, ADP = adenosine diphosphate.</p