9 research outputs found
Spatial and temporal distribution of notified tuberculosis cases in Nairobi County, Kenya, between 2012 and 2016
- Author
- Publication venue
- 'African Journals Online (AJOL)'
- Publication date
- 29/05/2018
- Field of study
Background: Tuberculosis (TB) is an infectious disease of major public health concern globally. The disease has showed spaceâtime variations across settings. Spatial temporal assessment can be used to understand the distribution and variations of TB disease.Objective: To determine the spatial and temporal distribution of notified TB cases in Nairobi County, Kenya, between 2012 and 2016Design: A cross sectional studySetting: Nairobi County, KenyaSubjects: Tuberculosis cases notified in Tuberculosis Information for Basic Units from 2012 to 2016Results: A total of 70,505 cases of TB were notified in Nairobi County between 2012 and 2016, with male to female ratio of 3:2 and HIV coinfection rate of 38%.The temporal analysis showed a declining trend of the notified cases. The spatial clusters showed stability in most areas while others varied annually during the study period. The spaceâtime analysis also detected the four most likely clusters or hotspots. Cluster 1 which covered the informal settlements of Kibera, Kawangware and Kangemi with 4,011observed cases against 2,977expected notified TB cases(relative risk (RR) 1.37, p<0.001). Further, Cluster 2 covered Starehe and parts of Kamukunji, Mathare, Makadara, Kibra and Dagoretti North Constituencies (RR 1.93, p<0.001; observed and expected cases were 4,206 and 2,242, respectively.Conclusion: This study identified high TB case notifications, declining temporal trends and clustering of TB cases in Nairobi. Evidence of clustering of TB cases indicates the need for focused interventions in the hotspot areas. Strategies should be devised for continuous TB surveillance and evidence based decision making
Track D Social Science, Human Rights and Political Science
- Author
- Abdelrahman E.
- Abramovitz D.
- Aburto HernĂĄndez K.e.
- Acaba J.
- Achan J.
- Adams M.
- Ades V.
- Adjei B.
- Agniel D.
- Aher A.
- Ahmed A.
- Akello M.
- Akinyosoye S.A.
- Akondeng L.
- Akter M.H.
- Alam N.
- Alaoui Hasnouni R.
- Alicea S.
- Amman P.
- Amram O.
- Anabwani G.M.
- Anabwani G.M.
- Anamaria P.
- Anastos K.
- Andrasik M.
- Anema A.
- Angotti N.
- Arumugam V.
- Atun R.
- Auerbach J.
- Aunon F.M.
- Awuoche H.
- Ayala G.
- Ayoola J.K.
- Babu Ndyabahika A.
- Bacic J.
- Bagfegue Ekani B.
- Baggaley R.
- Balakireva O.
- Balasundaram S.
- Banyan A.
- Baral S.
- Barrington C.
- Bautistaâarredondo S.
- Baye M.
- Beck J.
- Begum S.
- Bekalu M.A.
- Belize nasa Teams Guatemalabelize
- Bell M.
- Bell M.
- Belton S.
- Bendezu J.
- Benkirane M.
- Berger P.
- Bergerâgreenstein J.
- Bernard D.
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- Berona J.
- Bertil C.
- Betteridge G.
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- Bissek A.C.
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- Blanc L.
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- Bogart L.
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- Bonnel R.
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- Brewsterâlee D.
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/10/2012
- Field of study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd
Government Quality Determinants of ICT Adoption in Sub-Saharan Africa
- Author
- A B Singh
- A Breuer
- A Chan
- A Dixit
- A Fosu
- A Fosu
- A Fosu
- A Gani
- A K Fosu
- A Ojo
- A R Andrïżœs
- Al Surikhi
- B C Snow
- B H Baltagi
- B Maurer
- C Fonchingong
- C Z Qiang
- D Kaufmann
- D Kaufmann
- D Kaufmann
- D Roodman
- D Roodman
- E Asiedu
- E Morozov
- F Fukuyama
- G Grossman
- G Porter
- I Gagliardone
- I Love
- J
- J Anyanwu
- J C Aker
- J H Pierskalla
- J Hellstrom
- J Kiessling
- J N Weidmann
- L Diamond
- M Arellano
- M Arellano
- M Billon
- M Kurtz
- M Kurtz
- M Manacorda
- M Matthias
- M Muto
- Nicholas Biekpe
- O K Kirui
- P E Petrakis
- P Ondiege
- R A Andrïżœs
- R A Andrïżœs
- R Blundell
- R F Tusalem
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S Bond
- S Boulianne
- S Dewan
- S L Suarez
- S Oluwatobi
- Simplice A. Asongu
- T Penard
- U Efobi
- V Mishra
- V S Tchamyou
- World Bank
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Dynamics, Impact, and Feasibility of Self-Monitoring of Blood Glucose in the Rural, Resource-Constrained Setting of Western Kenya
- Publication venue
- 'American Diabetes Association'
- Publication date
- Field of study
Use of topical versus injectable anaesthesia for ShangRing circumcisions in men and boys in Kenya: Results from a randomized controlled trial
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2019
- Field of study
Background: The ShangRing is a disposable, collar clamp circumcision device pre-qualified for use in men and boys 13 years and above. It has been shown to be faster than conventional circumcision with comparable adverse event (AE) rates and high client satisfaction. Voluntary medical male circumcision (VMMC) has been shown to dramatically reduce the risk of HIV acquisition in males. However, the fear of pain during circumcision is an important barrier to uptake. Use of topical anesthesia thus presents an opportunity to address this. Objectives: We sought to evaluate the safety, effectiveness and acceptability of the use of topical anaesthesia with ShangRing circumcision of men and boys 10 years of age and above. Methods: Participants were randomised 2:1 to receive topical or injectable anaesthesia. All participants underwent no-flip ShangRing circumcision. The primary outcome measure was pain. Secondary outcomes included ease of use of topical versus injectable anaesthesia, AEs and participant satisfaction. Results: Compared to the topical group, participants in the injectable group reported significantly more pain on administration of the anesthesia and at approximately 20 minutes after the procedure. In the topical group, sufficient anaesthesia with topical cream was not achieved in 21 (9.3%) cases before the start of the procedure; in another 6 (2.6%), supplementary injectable anaesthesia was required as the circumcision was being carried out. The AE rate was significantly lower (p \u3c 0.01) in the topical (0%) vs. the injectable group (4.2%). The most common AE was pain during the post-operative period. All AEs were managed conservatively and resolved without sequeale. 96.7% of participants were satisfied with the appearance of the healed penis and 100% would recommend the ShangRing to others. All seven male circumcision providers involved in the study preferred topical to injectable anaesthesia. Conclusions: Our results demonstrate the safety, improved clinical experience, effectiveness, and acceptability of the use of topical anaesthesia in ShangRing circumcision using the no-flip technique. Topical anaesthesia effectively eliminates needlestick pain from the clientsâ VMMC experience and thus has the potential to increase demand for the service
Mobile banking usage, quality of growth, inequality and poverty in developing countries
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Building Knowledge-Based Economies in Africa: A Systematic Review of Policies and Strategies
- Author
- A B Kamara
- A B Singh
- A Boateng
- A Gosavi
- A R Andrïżœs
- A R Andrïżœs
- A Shahabadi
- Al Surikhi
- B A Kusi
- B A Kusi
- B B Sa?lam
- B Maurer
- C H Albach
- D T Gerba
- E Ondari-Okemwa
- H Issahaku
- H Mpogole
- J Barth
- J C Aker
- J D Jansen
- J I Uduji
- J I Uduji
- J I Uduji
- J I Uduji
- J J Britz
- J R Minkoua Nzie
- J Suh
- J Y Abor
- K Michealowa
- L Lomofsky
- L Tikly
- M A Geo-Jaja
- M Dembïżœlïżœ
- M Jellal
- M Kliner
- M Muto
- M O Oketch
- N Garoupa
- N Zghidi
- Nicholas Odhiambo
- O J Parcero
- O K Kirui
- O Oyewole
- R Gama
- R J Botha
- R J G M Florax
- R J Singh
- R Vadra
- R0kr101official0use0only1
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S A Asongu
- S N Mensah
- S S O M Nour
- S Ureta
- S V Tchamyou
- Simplice Asongu
- T D Stanley
- T L Bezmen
- T Penard
- T Triki
- U R Efobi
- V H Amavilah
- V Mishra
- V S Tchamyou
- V S Tchamyou
- V S Tchamyou
- V S Tchamyou
- World Bank
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
- Author
- Abach J
- Abdallah J
- Abdallah S
- Abdallah S
- Aberle-Grasse J
- Abimiku A
- Abishev A
- Abongomera G
- Aboud M
- Aboud M
- Abramovitz D
- Abrams E
- Abrams E
- Abrams E
- Abrams E
- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
- Adeyemi O
- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
- Agolory S
- Agot K
- Agot K
- Agovi A-A
- Aguiar P
- Aguilar-Martinez J
- Agutu C
- Ahmed M
- Ahmed R
- Ahmed S
- Ahmed S
- Ahmed S
- Aizire J
- Ajibola G
- Ajok S
- Albert-Hope C
- Alejos B
- Alexander G
- Alicea C
- Allen H
- Allen M
- Allen S
- Allen S
- Allen S
- Alloui C
- Altice F
- Altice F
- Amara R
- Ambani A
- Ambrose K
- Amico R
- Amin J
- Amin T
- Amole C
- Amoros I
- Anahtar M
- Ananworanich J
- Ananworanich J
- Ancuta P
- Andama A
- Anderegg N
- Anderson A
- Anderson A
- Anderson E
- Anderson J
- Anderson J
- Anderson S
- Andersson M
- Andrade A
- Andrew E
- Andrew P
- Andrew P
- Andrews L
- Angel J
- Angelidou K
- Anglaret X
- Anoma C
- Ansari A
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apetrei C
- Apollon A
- Apondi E
- Aptekar S
- Ardiet D
- Arellano G
- Arenas-Pinto A
- Arhel N
- Armstrong D
- Arthos J
- Artz L
- Arunmanakul A
- Asari V
- Asege L
- Asiimwe S
- Asiimwe S
- Asiimwe S
- Asokan M
- Aspin C
- Athiambo M
- Atuhumuza E
- Atujuna M
- Audet C
- Auerbach J
- Auld A
- Aung P
- Aurpibul L
- Aurpibul L
- Avalos A
- Avihingsanon A
- Avihingsanon A
- Avihingsanon A
- Awori Q
- Awotwi E
- Ayala V
- Ayalew M
- Ayaya S
- Ayieko J
- Ayieko J
- Ayieko J
- Aylott A
- Azar M
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- Azizuyo B
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated
8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).
- Author
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- Stirratt M
- Stirratt M
- Stojiljkovic T
- Strathdee S
- Strathdee S
- Strathdee SA
- Strumpf EC
- Struthers H
- Stuart R
- Sudjaritruk T
- Sudjaritruk T
- Sugandhi N
- Sulaberidze L
- Sulkowski M
- Sulkowski MS
- Sulkowski MS
- Sun X
- Sungkanuparph S
- Sunseri N
- Supervie V
- Suthar A
- Suttichom D
- Swanstrom R
- Swanstrom R
- Sweitzer S
- Swindells S
- Switzer WM
- Sylla M
- Sypsa V
- Szumilin E
- Taha T
- Taiwo B
- Takebe Y
- Tal K
- Taljjard D
- Tang W
- Tang W
- Tanser F
- Tanser F
- Tapia K
- Taruberekera N
- Tayea A
- Taylor A
- Taylor J
- Tayong G
- Teague A
- Techapornroong M
- Tee KK
- Teeraananchai S
- Tenakoon S
- Tene G
- Tenthani L
- Teodoro E
- Teppler H
- Terris-Prestholt F
- TerĂĄn GR
- Thai H
- Thirumurthy H
- Thirumurthy H
- Thirumurthy H
- Thomas KK
- Thomas R
- Thompson D
- Thompson LH
- Thompson M
- Tih PM
- Timimi HB
- Tippanonth N
- Tiraboschi JM
- Toby M
- Toibaro J
- Tollman S
- Tomaras G
- Torres S
- Townley E
- Trahan M-J
- Tran HT
- Traore B
- Trapence G
- Treves-Kagan S
- Treves-Kagan S
- Trichavaroj R
- Trichavaroj R
- Trinh R
- Trunfio M
- Truong KH
- Trypsteen W
- Tsereteli N
- Tucker J
- Tumba N
- Tumbare E
- Tumwesigye E
- Turrini F
- Turyamureeba B
- Twine R
- Twine R
- Twine R
- Uebel KE
- Umar E
- Urien S
- Valantin MA
- Valenzuela-Ponce H
- Valenzuela-Ponce H
- van der Elst L
- Van Eygen V
- van Heerden A
- van Lettow M
- Van Lint C
- Van Lunzen J
- Van Nguyen L
- Van Nguyen TT
- van Oosterhout J
- van Oosterhout JJ
- Van Rompay K
- van Rooyen H
- Van Schalkwyk J
- Vandekerckhove L
- Vandendriessche A
- Vasarhelyi K
- Vaudry W
- Vaudry W
- Veloso VG
- Veloso VG
- Venter F
- Ventura A
- Verhofstede C
- Vermillion M
- Vernazza P
- Vervisch K
- Vets S
- Viana R
- Vibeke R
- Vicenzi E
- Vicol LA
- Viljoen K
- Villinger F
- Vincent T
- Vitoria M
- Vittinghoff E
- Volberding P
- Volokha A
- von Werder A
- Vu QD
- Wagner A
- Wagner R
- Wagner T
- Wainberg M
- Wainfen W
- Walker BD
- Walker BD
- Walker-Sperling V
- Wallis C
- Walmsley S
- Wamalwa D
- Wamalwa D
- Wambura M
- Wamicwe J
- Wanasiri P
- Wang C
- Wang J
- Wang J
- Wang Z
- Warnke A
- Warszawski J
- Watadzaushe C
- Waterhouse D
- Wawer M
- Weaver E
- Webb GM
- Wei C
- Wei X
- Weidle P
- Weiser B
- Weiss H
- Weissenhorn W
- Welty T
- Welty T
- Wendoh J
- Wenzi LK
- Werb D
- Wertheim JO
- Westgard T
- Wiesner L
- Wijayaratne S
- Wilen C
- Wilkinson L
- Williams T
- Wilson CM
- Wilson D
- Wimonsate W
- Wittkop L
- Woelk G
- Wolf E
- Wolff M
- Wolters L
- Wood E
- Wood E
- Wood E
- Wood E
- Woods C
- Wu HL
- Wu V
- Wyles D
- Wylie JL
- Xaba T
- Xia G
- Xiao H
- Xing Y
- Xu D
- Xu J
- Xu X
- Yang B
- Yang JC
- Yang L
- Yao KA
- Yassi A
- Yates N
- Yazdanpanah Y
- Yin M
- Yindom L-M
- Yotebieng M
- Young J
- Young P
- Youngleson M
- Yu Y
- Zablotska I
- Zamor P
- Zang O
- Zash R
- Zerbe A
- Zhang M
- Zhang Y
- Zhang Y
- Zhou S
- Zhuang M
- Ziegler JB
- Zink A
- Zink C
- Zolla-Pazner S
- Zolopa A
- Zolowere DB
- Zou H
- Zuma N
- ĂsbjörnsdĂłttir KH
- Ăvila-RĂos S
- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2015
- Field of study