Histopathological Imaging Classification of Breast Tissue for Cancer Diagnosis Support Using Deep Learning Models

According to some medical imaging techniques, breast histopathology images called Hematoxylin and Eosin are considered as the gold standard for cancer diagnoses. Based on the idea of dividing the pathologic image (WSI) into multiple patches, we used the window [512,512] sliding from left to right and sliding from top to bottom, each sliding step overlapping by 50% to augmented data on a dataset of 400 images which were gathered from the ICIAR 2018 Grand Challenge. Then use the EffficientNet model to classify and identify the histopathological images of breast cancer into 4 types: Normal, Benign, Carcinoma, Invasive Carcinoma. The EffficientNet model is a recently developed model that uniformly scales the width, depth, and resolution of the network with a set of fixed scaling factors that are well suited for training images with high resolution. And the results of this model give a rather competitive classification efficiency, achieving 98% accuracy on the training set and 93% on the evaluation set.Comment: International Conference on Industrial Networks and Intelligent Systems (INISCOM-2022), Springer, Vol. 444, pp. 152-16

AGING OF WATERBORNE PAINT BASED ON THE ACRYLIC RESIN EMULSION AND ORGANIC PIGMENT

Aging of waterborne paint on the base of acrylic resin emulsion with and without green Luconyl have been investigated by general appearance assessment, adhesion change, FT-IR and discoloration. The obtained results showed that the both of paint-formulas coatings had no cracks, blisters, flacks and there was no change of adhesion during the aging process. However, IR analysis indicated that there were some changes in chemical structures of coating with and without Green Luconyl during aging process. To specify, IR spectrums of initial and aged coating no containing Green Luconyl illustrated aging process led content of O-H and C=C increased significantly but baseline of spectra was fairly unchanged. For coating filled Green Luconyl, IR spectrums’ shape was fairly stable but baseline saw a clear reduce during accelerated weather exposure. Moreover, SEM images indicated that surfaces morphology of samples changed differently depending on in presence of organic pigment. Surface of aged coating without Luconyl saw rougher than surface of coating with Luconyl after aging process. Hence, the weather aging test had more significant influence on paint coating in absence of Luconyl than paint coating in presence of Luconyl. It was explained that the macroradical produced in aging process would attack into conjugated double bonds of Luconyl instead of double bonds of AC-261 leading to aged coating filled Luconyl become more opaque than initial while coating no filled Luconyl had significant changes in chemical structure during aging process. Although this was a hypothesis, it saw a suitable with the obtained results. The paint coating in presence of Luconyl illustrated significant color change, especially, showed the loss of green color while the other paint coating showed slight color change

OXIDIZED MAIZE STARCH: CHARACTERIZATION AND EFFECT OF IT ON THE BIODEGRADABLE FILMS I. CHARACTERIZATION OF MAIZE STARCH OXIDIZED BY SODIUM HYPOCHLORITE

The effects of hypochlorite level, i.e. 0.5; 1 and 2 active chlorine g/100g starch, on the structures and physicochemical properties of oxidized maize starch were investigated. The obtained results shown that oxidation degree grew up with increasing hypochlorite concentration, specially, the carboxyl content saw higher increased than the content of carbonyl. SEM images indicated that surface of oxidized maize starches were rougher than native starch. The surface of oxidized starches saw rougher with increasing hypochlorite level. However, the DSC results illustrated that there was no significant difference of gelatinization temperature between the native starch and oxidized starches

Antibacterial Nanocomposites Based on Fe 3

For the vulcanized natural rubber (NR), incorporation of silver nanoparticles (AgNPs) into the NR matrix did not exhibit the bactericidal property against Escherichia coli (E. coli). However, incorporation of AgNPs into polyethylene (PE) matrix showed good antibacterial activities to both Gram-negative and Gram-positive bacteria. In the present work, NR/PE (85/15) blends have been prepared by melt blending with presence of compatibilizer in an internal mixer. To possess antibacterial property, AgNPs (5–10 nm) or Fe3O4–Ag hybrid nanoparticles (FAgNPs, 8 nm/16 nm) were added into PE matrix before its blending with NR component. The tensile test indicated that the presence of compatibilizer in NR/PE blend significantly enhanced the tensile strength and elongation at break (up to 35% and 38% increases, resp.). The antibacterial activity test was performed by monitoring of the bacterial lag-log growth phases with the presence of nanocomposites in the E. coli cell culture reactor. The antibacterial test showed that the presence of FAgNPs in NR/PE blend had a better antibacterial activity than that obtained with the lone AgNPs. Two similar reasons were proposed: (i) the faster Ag+ release rate from the Fe3O4–Ag hybrid nanoparticles due to the electron transfer from AgNP to Fe3O4 nanoparticle and (ii) the fact that the ionization of AgNPs in hybrid nanostructure might be accelerated by Fe3+ ions

Some chalcones derived from thio-phene-3-carbaldehyde: synthesis and crystal structures.

The synthesis, spectroscopic data and crystal and mol-ecular structures of four 3-(3-phenyl-prop-1-ene-3-one-1-yl)thio-phene derivatives, namely 1-(4-hydroxy-phen-yl)-3-(thio-phen-3-yl)prop-1-en-3-one, C13H10O2S, (1), 1-(4-meth-oxy-phen-yl)-3-(thio-phen-3-yl)prop-1-en-3-one, C14H12O2S, (2), 1-(4-eth-oxy-phen-yl)-3-(thio-phen-3-yl)prop-1-en-3-one, C15H14O2S, (3), and 1-(4--bromophen-yl)-3-(thio-phen-3-yl)prop-1-en-3-one, C13H9BrOS, (4), are described. The four chalcones have been synthesized by reaction of thio-phene-3-carbaldehyde with an aceto-phenone derivative in an absolute ethanol solution containing potassium hydroxide, and differ in the substituent at the para position of the phenyl ring: -OH for 1, -OCH3 for 2, -OCH2CH3 for 3 and -Br for 4. The thio-phene ring in 4 was found to be disordered over two orientations with occupancies 0.702 (4) and 0.298 (4). The configuration about the C=C bond is E. The thio-phene and phenyl rings are inclined by 4.73 (12) for 1, 12.36 (11) for 2, 17.44 (11) for 3 and 46.1 (6) and 48.6 (6)° for 4, indicating that the -OH derivative is almost planar and the -Br derivative deviates the most from planarity. However, the substituent has no real influence on the bond distances in the α,β-unsaturated carbonyl moiety. The mol-ecular packing of 1 features chain formation in the a-axis direction by O-H⋯O contacts. In the case of 2 and 3, the packing is characterized by dimer formation through C-H⋯O inter-actions. In addition, C-H⋯π(thio-phene) inter-actions in 2 and C-H⋯S(thio-phene) inter-actions in 3 contribute to the three-dimensional architecture. The presence of C-H⋯π(thio-phene) contacts in the crystal of 4 results in chain formation in the c-axis direction. The Hirshfeld surface analysis shows that for all four derivatives, the highest contribution to surface contacts arises from contacts in which H atoms are involved

Crystal structure of two <i>N</i>'-(1-phenyl-benzyl-idene)-2-(thio-phen-3-yl)acetohydrazides.

The synthesis, spectroscopic data, crystal and mol-ecular structures of two N'-(1-phenyl-benzyl-idene)-2-(thio-phen-3-yl)acetohydrazides, namely N'-[1-(4-hy-droxy-phen-yl)benzyl-idene]-2-(thio-phen-3-yl)acetohydrazide, C13H10N2O2S, (3a), and N'-[1-(4-meth-oxy-phen-yl)benzyl-idene]-2-(thio-phen-3-yl)acetohydrazide, C14H14N2O2S, (3b), are described. Both compounds differ in the substituent at the para position of the phenyl ring: -OH for (3a) and -OCH3 for (3b). In (3a), the thio-phene ring is disordered over two orientations with occupancies of 0.762 (3) and 0.238 (3). The configuration about the C=N bond is E. The thio-phene and phenyl rings are inclined by 84.0 (3) and 87.0 (9)° for the major- and minor-occupancy disorder components in (3a), and by 85.89 (12)° in (3b). Although these dihedral angles are similar, the conformation of the linker between the two rings is different [the C-C-C-N torsion angle is -ac for (3a) and -sc for (3b), while the C6-C7-N9-N10 torsion angle is +ap for (3a) and -sp for (3b)]. A common feature in the crystal packing of (3a) and (3b) is the presence of N-H⋯O hydrogen bonds, resulting in the formation of chains of mol-ecules running along the b-axis direction in the case of (3a), or inversion dimers for (3b). The most prominent contributions to the surface contacts are those in which H atoms are involved, as confirmed by an analysis of the Hirshfeld surface

Exploring Italian Consumers’ Willingness to Pay for Sustainable Fashion: The Roles of Eco-Consciousness and Vintage Preference

Studying the psychology behind the purchase of eco-friendly products and second-hand items can offer valuable insights to promote sustainable consumer behavior. This paper examines factors influencing Italian consumers’ willingness to pay regarding bio-based clothing and second-hand items. Drawing from data collected from 402 Italian participants, we examine how motivations and socio-demographic factors are associated with willingness to pay in the context of sustainable fashion. Our findings reveal that motivations related to environmental concerns are positively associated with consumers’ willingness to pay higher premiums for bio-based clothing. Higher income and education levels are also associated with the willingness to pay higher premiums. Meanwhile, motivation related to vintage appeal is associated with lower desired discounts for second-hand items, particularly among older consumers. Gender differences also influence discount preferences, with men seeking larger discounts on second-hand clothing compared to women. By providing insights into Italian consumers’ sustainable fashion choices, this study offers implications for businesses, policymakers, and researchers aiming to promote eco-conscious consumption and sustainability in the fashion industry

Synthesis, crystal structure and Hirshfeld surface analysis of 4-[3-(4-hy-droxy-phen-yl)-4,5-di-hydro-1H-pyrazol-5-yl]-2-meth-oxy-phenol monohydrate.

In the title pyrazoline derivative, C16H16N2O3·H2O, the pyrazoline ring has an envelope conformation with the substituted sp 2 C atom on the flap. The pyrazoline ring makes angles of 86.73 (12) and 13.44 (12)° with the tris-ubstituted and disubstituted benzene rings, respectively. In the crystal structure, the mol-ecules are connected into chains running in the b-axis direction by O-H⋯N hydrogen bonding. Parallel chains inter-act through N-H⋯O hydrogen bonds and π-π stacking of the tris-ubstituted phenyl rings. The major contribution to the surface contacts are H⋯H contacts (44.3%) as concluded from a Hirshfeld surface analysis

Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease.

BACKGROUND: Brainstem encephalitis is a serious complication of hand foot and mouth disease (HFMD) in children. Autonomic nervous system (ANS) dysregulation and hypertension may occur, sometimes progressing to cardiopulmonary failure and death. Vietnamese national guidelines recommend use of milrinone if ANS dysregulation with Stage 2 hypertension develops. We wished to investigate whether magnesium sulfate (MgSO4) improved outcomes in children with HFMD if used earlier in the evolution of the ANS dysregulation (Stage 1 hypertension). METHODS: During a regional epidemic we conducted a randomized, double-blind, placebo-controlled trial of MgSO4 in children with HFMD, ANS dysregulation and Stage 1 hypertension, at the Hospital for Tropical Diseases in Ho Chi Minh city. Study participants received an infusion of MgSO4 or matched placebo for 72 h. We also reviewed data from non-trial HFMD patients in whom milrinone failed to control hypertension, some of whom received MgSO4 as second line therapy. The primary outcome for both analyses was a composite of disease progression within 72 h - addition of milrinone (trial participants only), need for ventilation, shock, or death. RESULTS: Between June 2014 and September 2016, 14 and 12 participants received MgSO4 or placebo respectively, before the trial was stopped due to futility. Among 45 non-trial cases with poorly controlled hypertension despite high-dose milrinone, 33 received MgSO4 while 12 did not. There were no statistically significant differences in the composite outcome between the MgSO4 and the placebo/control groups in either study (adjusted relative risk (95%CI) of [6/14 (43%) vs. 6/12 (50%)], 0.84 (0.37, 1.92), p = 0.682 in the trial and [1/33 (3%) vs. 2/12 (17%)], 0.16 (0.01, 1.79), p = 0.132 in the observational cohort). The incidence of adverse events was similar between the groups. Potentially toxic magnesium levels occurred very rarely with the infusion regime used. CONCLUSION: Although we could not demonstrate efficacy in these studies, there were no safety signals associated with use of 30-50 mg/kg/hr. MgSO4 in severe HFMD. Intermittent outbreaks of HFMD are likely to continue across the region, and an adequately powered trial is still needed to evaluate use of MgSO4 in controlling hypertension in severe HFMD, potentially involving a higher dose regimen. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01940250 (Registered 22 AUG 2013). Trial sponsor: University of Oxford

Effect of Silica Nanoparticles on Properties of Coatings Based on Acrylic Emulsion Resin

Effect of nanosilica size on physic-mechanical properties, thermal stability and weathering durability of coating based on acrylic emulsion. Nanocomposite coating formulas were filled by 2 wt.% nanosilica particles which were used in this study, namely: nanosilica from Sigma (15-20nm), nansilica from rice husk (~70-200 nm) and nanosilica from Arosil – Belgium (7-12 nm). Obtained results showed that viscosity flow of coating formula containing nanosilica from Arosil saw the highest flow-time while coating formulas filled other nanosilica and unfilled nanosilica experienced similar flow-time. In presence of nanosilica, coating properties were improved in comparison with neat coating. However, coating filled by nanosilica from rice husk indicated the best properties in studied coating formula. It may explained that size of nanosilica from rice husk was the largest in studied nanosilica particles and thus easily dispersing into coating formula