Fostering equitable access to higher education in Hong Kong : a study of the tertiary financial assistance scheme

published_or_final_versionPolitics and Public AdministrationMasterMaster of Public Administratio

Acupuncture for frozen-thawed embryo transfer cycles: A double-blind randomized controlled trial

The role of acupuncture on the pregnancy rate has not been evaluated in frozen-thawed embryo transfer (FET) cycles. This randomized double-blind study aimed to determine whether acupuncture performed on the day of FET improves clinical outcomes. On the day of FET, 226 patients were randomly allocated to either real or placebo acupuncture according to a computergenerated randomization list in sealed opaque envelopes. They received a session of real or placebo acupuncture for 25 min on site immediately after FET. The anxiety level and serum cortisol concentration were evaluated before and after real and placebo acupuncture. There were no significant differences in rates of overall pregnancy, clinical pregnancy, ongoing pregnancy, live birth and implantation in the placebo acupuncture group, when compared with the real acupuncture group. The anxiety level and serum cortisol concentration were similar for both groups. Only the placebo acupuncture group had significantly higher ongoing pregnancy (P = 0.022) and implantation rates (P = 0.038) than those who declined to join the study and received no acupuncture. In conclusion, comparable pregnancy and live birth rates of FET treatment were found in patients who had one session of real or placebo acupuncture after FET. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.postprin

Edge-Assisted V2X Motion Planning and Power Control Under Channel Uncertainty

Edge-assisted vehicle-to-everything (V2X) motion planning is an emerging paradigm to achieve safe and efficient autonomous driving, since it leverages the global position information shared among multiple vehicles. However, due to the imperfect channel state information (CSI), the position information of vehicles may become outdated and inaccurate. Conventional methods ignoring the communication delays could severely jeopardize driving safety. To fill this gap, this paper proposes a robust V2X motion planning policy that adapts between competitive driving under a low communication delay and conservative driving under a high communication delay, and guarantees small communication delays at key waypoints via power control. This is achieved by integrating the vehicle mobility and communication delay models and solving a joint design of motion planning and power control problem via the block coordinate descent framework. Simulation results show that the proposed driving policy achieves the smallest collision ratio compared with other benchmark policies

Communication Resources Constrained Hierarchical Federated Learning for End-to-End Autonomous Driving

While federated learning (FL) improves the generalization of end-to-end autonomous driving by model aggregation, the conventional single-hop FL (SFL) suffers from slow convergence rate due to long-range communications among vehicles and cloud server. Hierarchical federated learning (HFL) overcomes such drawbacks via introduction of mid-point edge servers. However, the orchestration between constrained communication resources and HFL performance becomes an urgent problem. This paper proposes an optimization-based Communication Resource Constrained Hierarchical Federated Learning (CRCHFL) framework to minimize the generalization error of the autonomous driving model using hybrid data and model aggregation. The effectiveness of the proposed CRCHFL is evaluated in the Car Learning to Act (CARLA) simulation platform. Results show that the proposed CRCHFL both accelerates the convergence rate and enhances the generalization of federated learning autonomous driving model. Moreover, under the same communication resource budget, it outperforms the HFL by 10.33% and the SFL by 12.44%

Baicalein antagonizes rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to Parkinsonism

<p>Abstract</p> <p>Background</p> <p>Two active compounds, baicalein and its glycoside baicalin were found in the dried root of <it>Scutellaria baicalensis </it>Georgi, and reported to be neuroprotective <it>in vitro </it>and <it>in vivo</it>. This study aims to evaluate the protective effects of baicalein on the rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to parkinsonism.</p> <p>Methods</p> <p>Cell viability and cytotoxicity were determined by MTT assay. The degree of nuclear apoptosis was evaluated with a fluorescent DNA-binding probe Hoechst 33258. The production of reactive oxidative species (ROS) and loss of mitochondrial membrane potential (ΔΨm) were determined by fluorescent staining with DCFH-DA and Rhodanmine 123, respectively. The expression of Bax, Bcl-2, cleaved caspase-3 and phosphorylated ERK1/2 was determined by the Western blots.</p> <p>Results</p> <p>Baicalein significantly increased viability and decreased rotenone-induced death of SH-SY5Y cells in a dose-dependent manner. Pre- and subsequent co-treatment with baicalein preserved the cell morphology and attenuated the nuclear apoptotic characteristics triggered by rotenone. Baicalein antagonized rotenone-induced overproduction of ROS, loss of ΔΨm, the increased expression of Bax, cleaved caspase-3 and phosphorylated ERK1/2 and the decreased expression of Bcl-2.</p> <p>Conclusion</p> <p>The antioxidative effect, mitochondrial protection and modulation of anti-and pro-apoptotic proteins are related to the neuroprotective effects of baicalein against rotenone induced cell death in SH-SY5Y cells.</p

Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells

The cardioprotective effects of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (apoA-I) are well documented, but their effects in the direction of the cardiac differentiation of embryonic stem cells are unknown. We evaluated the effects of exogenous apoA-I expression on cardiac differentiation of ESCs and maturation of ESC-derived cardiomyocytes. We stably over-expressed full-length human apoA-I cDNA with lentivirus (LV)-mediated gene transfer in undifferentiated mouse ESCs and human induced pluripotent stem cells. Upon cardiac differentiation, we observed a significantly higher percentage of beating embryoid bodies, an increased number of cardiomyocytes as determined by flow cytometry, and expression of cardiac markers including α-myosin heavy chain, β-myosin heavy chain and myosin light chain 2 ventricular transcripts in LV-apoA-I transduced ESCs compared with control (LV-GFP). In the presence of noggin, a BMP4 antagonist, activation of BMP4-SMAD signaling cascade in apoA-I transduced ESCs completely abolished the apoA-I stimulated cardiac differentiation. Furthermore, co-application of recombinant apoA-I and BMP4 synergistically increased the percentage of beating EBs derived from untransduced D3 ESCs. These together suggests that that pro-cardiogenic apoA-I is mediated via the BMP4-SMAD signaling pathway. Functionally, cardiomyocytes derived from the apoA-I-transduced cells exhibited improved calcium handling properties in both non-caffeine and caffeine-induced calcium transient, suggesting that apoA-I plays a role in enhancing cardiac maturation. This increased cardiac differentiation and maturation has also been observed in human iPSCs, providing further evidence of the beneficial effects of apoA-I in promoting cardiac differentiation. In Conclusion, we present novel experimental evidence that apoA-I enhances cardiac differentiation of ESCs and iPSCs and promotes maturation of the calcium handling property of ESC-derived cardiomyocytes via the BMP4/SMAD signaling pathway

Bridging dentistry and traditional Chinese medicine : a study on the current mutual understanding among the future practitioners

Objectives: This project aimed to promote the mutual understanding between dental and TCM students. The objectives were to describe the current teaching of dentistry in the TCM schools and that of TCM in the dental school, to describe the TCM students’ knowledge on dentistry and the dental students’ knowledge on TCM, and to produce promotional materials for enhancing the mutual understanding between dental and TCM students. Methods: Information on the current teaching of dentistry in the TCM schools and that of TCM in the dental school was collected through a search on the undergraduate programme syllabus and conducting interviews with the leaders of the schools. Questionnaire surveys were conducted among the final year students of the TCM and the dental schools to collect information on their knowledge of the counter profession. Two leaflets and a short video were produced with the aid of computer software and used in the promotional activities. Results: It was found that very little information on dentistry was covered in the undergraduate programmes of the three TCM schools, and vice versa in the dental school. A total of 39 TCM students and 55 dental students completed the questionnaire survey. Most of the students did not know the basic theories and practice of the counter profession. Less than half of the student knew what types of patient cases may be suitable for cross-referral to the other profession. Conclusions: The TCM and dental schools in Hong Kong do not have scheduled teaching on the counter profession. The TCM students have little knowledge on dentistry and how to collaborate with dental practitioners on patients presented with oral problems. Conversely, it is the same for the dental students. Lastly, informative printed and audio-visual promotional materials can be produced with limited resources and used to facilitate the mutual understanding between TCM and dental practitioners.published_or_final_versio

A 21-Year-Old Pregnant Woman with Hypertension and Proteinuria

Ronald Ma and colleagues describe the differential diagnosis, investigation, and management of a 21-year-old pregnant woman presenting with hypertension and proteinuria at 20 weeks of gestation

CHASM and SNVBox: toolkit for detecting biologically important single nucleotide mutations in cancer

Summary: Thousands of cancer exomes are currently being sequenced, yielding millions of non-synonymous single nucleotide variants (SNVs) of possible relevance to disease etiology. Here, we provide a software toolkit to prioritize SNVs based on their predicted contribution to tumorigenesis. It includes a database of precomputed, predictive features covering all positions in the annotated human exome and can be used either stand-alone or as part of a larger variant discovery pipeline