Relation between the separable and one-boson-exchange potential for the covariant Bethe-Salpeter equation

We investigate the relation between the rank I separable potential for the covariant Bethe-Salpeter equation and the one-boson-exchange potential. After several trials of the parameter choices, it turns out that it is not always possible to reproduce the phase-shifts calculated from a single term of the one-boson-exchange potential especially of the $\sigma$-exchange term, separately by the rank I separable potential. Instead, it is shown that the separable potential is useful to parameterize the total nucleon-nucleon interaction.Comment: 10 pages, 8 figures, to appear in J.Phys.

Completed cohomology of Shimura curves and a p-adic Jacquet-Langlands correspondence

We study indefinite quaternion algebras over totally real fields F, and give an example of a cohomological construction of p-adic Jacquet-Langlands functoriality using completed cohomology. We also study the (tame) levels of p-adic automorphic forms on these quaternion algebras and give an analogue of Mazur's `level lowering' principle.Comment: Updated version. Contains some minor corrections compared to the published versio

Three body problem in a dilute Bose-Einstein condensate

We derive the explicit three body contact potential for a dilute condensed Bose gas from microscopic theory. The three body coupling constant exhibits the general form predicted by T.T. Wu [Phys. Rev. 113, 1390 (1959)] and is determined in terms of the amplitudes of two and three body collisions in vacuum. In the present form the coupling constant becomes accessible to quantitative studies which should provide the crucial link between few body collisions and the stability of condensates with attractive two body forces

Lipid Management in Primary Care for Socioeconomically Disadvantaged Populations in Northern England: A Qualitative Study

INTRODUCTION: People in low socioeconomic circumstances are more susceptible to dyslipidemia and cardiovascular disease than those living in more affluent populations. Limited healthcare access and low preventive care uptake widen health inequalities. Understanding how primary care can better serve socioeconomically disadvantaged communities is urgently needed. AIM: To explore lipid management delivery in socioeconomically disadvantaged areas and identify barriers and enablers for lipid optimization for socioeconomically disadvantaged populations. METHOD: Individual semi-structured remote interviews with clinicians, purposively recruited from primary care practices serving extremely socioeconomically disadvantaged communities in Northern England, UK, who were involved in the delivery and organization of lipid management. Interviews were recorded, transcribed, and analyzed thematically following framework analysis. RESULTS: Fifteen interviews were undertaken. Five themes emerged: complex and multimorbid patients with competing priorities, limited access and follow-up to supporting services, being flexible and working beyond guidelines, high workload with inadequate staff support, and the need for care integrity and sustainable support. CONCLUSION: The findings of this study have been fed back to the delivery of the national program to improve cardiovascular health. Socioeconomically disadvantaged communities have complex health needs posing risks of multimorbidity but living with low health literacy, competing demands upon time, and financial constraints. Clinicians are willing to adapt services but a lack of guidance for care and funded services remains a significant barrier to targeted service delivery. Research is needed to inform the effectiveness and acceptability of interventions for lipid management tailored for those experiencing low socioeconomic disadvantage

Helicobacter pylori and cancer among adults in Uganda

Data from Africa on infection with Helicobacter pylori (H. pylori) are sparse. Therefore, as part of an epidemiological study of cancer in Uganda, we investigated the prevalence and determinants of antibodies against H. pylori among 854 people with different cancer types and benign tumours. Patients were recruited from hospitals in Kampala, Uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against H. pylori. In all patients combined, excluding those with stomach cancer (which has been associated with H. pylori infection), the prevalence of antibodies was 87% (723/833) overall, but declined with increasing age (p = 0.02) and was lower among people who were HIV seropositive compared to seronegative (p <0.001). Otherwise, there were few consistent epidemiological associations. Among those with stomach cancer, 18/21 (86%) had anti-H. pylori antibodies (odds ratio 0.8, 95% confidence intervals 0.2–2.9, p = 0.7; estimated using all other patients as controls, with adjustment for age, sex and HIV serostatus). No other cancer site or type was significantly associated with anti-H. pylori antibodies. The prevalence of H. pylori reported here is broadly in accord with results from other developing countries, although the determinants of infection and its' role in the aetiology of gastric cancer in Uganda remain unclear

Detecting cell lysis using viscosity monitoring in E. coli fermentation to prevent product loss

Monitoring the physical or chemical properties of cell broths to infer cell status is often challenging due to the complex nature of the broth. Key factors indicative of cell status include cell density, cell viability, product leakage and DNA release to the fermentation broth. The rapid and accurate prediction of cell status for hosts with intracellular protein products can minimise product loss due to leakage at the onset of cell lysis in fermentation. This paper reports the rheological examination of an industrially relevant E. coli fermentation system producing antibody fragments (Fab'). Viscosity monitoring showed an increase in viscosity during the exponential phase in relation to the cell density increase; this is a relatively flat profile in the stationary phase, followed by a rapid increase which correlated well with product loss, DNA release and loss of cell viability. This phenomenon was observed over several fermentations that a 25% increase in broth viscosity (using induction-point viscosity as a reference) indicated 10% product loss. Our results suggest that viscosity can accurately detect cell lysis and product leakage in post-induction cell cultures, and can identify cell lysis earlier than several other common fermentation monitoring techniques. This work demonstrates the utility of rapidly monitoring the physical properties of fermentation broths, and that viscosity monitoring has the potential to be a tool for process development to determine the optimal harvest time and minimise product los

Heat capacity uncovers physics of a frustrated spin tube

We report on refined experimental results concerning the low-temperature specific heat of the frustrated spin tube material [(CuCl2tachH)3Cl]Cl2. This substance turns out to be an unusually perfect spin tube system which allows to study the physics of quasi-one dimensional antiferromagnetic structures in rather general terms. An analysis of the specific heat data demonstrates that at low enough temperatures the system exhibits a Tomonaga-Luttinger liquid behavior corresponding to an effective spin-3/2 antiferromagnetic Heisenberg chain with short-range exchange interactions. On the other hand, at somewhat elevated temperatures the composite spin structure of the chain is revealed through a Schottky-type peak in the specific heat located around 2 K. We argue that the dominating contribution to the peak originates from gapped magnon-type excitations related to the internal degrees of freedom of the rung spins.Comment: 4+ pages, 6 figure

Molecular dynamics studies of the melting of butane and hexane monolayers adsorbed on the basal‐plane surface of graphite

doi:10.1063/1.465067The effect of molecular steric properties on the melting of quasi‐two‐dimensional solids is investigated by comparing results of molecular dynamics simulations of the melting of butane and hexane monolayers adsorbed on the basal‐plane surface of graphite. These molecules differ only in their length, being members of the n‐alkane series [CH3(CH2)n−2CH3] where n=4 for butane and n=6 for hexane. The simulations employ a skeletal model, which does not include the hydrogen atoms explicitly, to represent the intermolecular and molecule-substrate interactions. Nearest‐neighbor intramolecular bonds are fixed in length, but the molecular flexibility is preserved by allowing the bend and dihedral torsion angles to vary. The simulations show a qualitatively different melting behavior for the butane and hexane monolayers consistent with neutron and x‐ray scattering experiments. The melting of the low‐temperature herringbone (HB) phase of the butane monolayer is abrupt and characterized by a simultaneous breakdown of translational order and the orientational order of the molecules about the surface normal. In contrast, the hexane monolayer exhibits polymorphism in that the solid HB phase transforms to a rectangular‐centered structure with a short coherence length in coexistence with a fluid phase. A significant result of the simulations is that they demonstrate the importance of molecular flexibility on the nature of the melting transition. The formation of gauche molecules is essential for the melting process in the hexane monolayer but unimportant for butane. The effect of molecular length on the qualitative nature of the melting process is discussed for both monolayers.This work was supported by The Danish Natural Science Research Council Grant No. M 11-7015, the U.S. NSF Grants No. DMR-8704938 and No. DMR-9011069,and the Pittsburgh Supercomputing Center Grant No. DMR-880008P