Pervasive Parallel And Distributed Computing In A Liberal Arts College Curriculum

We present a model for incorporating parallel and distributed computing (PDC) throughout an undergraduate CS curriculum. Our curriculum is designed to introduce students early to parallel and distributed computing topics and to expose students to these topics repeatedly in the context of a wide variety of CS courses. The key to our approach is the development of a required intermediate-level course that serves as a introduction to computer systems and parallel computing. It serves as a requirement for every CS major and minor and is a prerequisite to upper-level courses that expand on parallel and distributed computing topics in different contexts. With the addition of this new course, we are able to easily make room in upper-level courses to add and expand parallel and distributed computing topics. The goal of our curricular design is to ensure that every graduating CS major has exposure to parallel and distributed computing, with both a breadth and depth of coverage. Our curriculum is particularly designed for the constraints of a small liberal arts college, however, much of its ideas and its design are applicable to any undergraduate CS curriculum

Pathogen-host reorganization during Chlamydia invasion revealed by cryo-electron tomography

Invasion of host cells is a key early event during bacterial infection, but the underlying pathogen-host interactions are yet to be fully visualised in three-dimensional detail. We have captured snapshots of the early stages of bacterial-mediated endocytosis in situ by exploiting the small size of chlamydial elementary bodies (EBs) for whole cell cryo-electron tomography. Chlamydiae are obligate intracellular bacteria that infect eukaryotic cells and cause sexually transmitted infections and trachoma, the leading cause of preventable blindness. We demonstrate that Chlamydia trachomatis LGV2 EBs are intrinsically polarised. One pole is characterised by a tubular inner membrane invagination, while the other exhibits asymmetric periplasmic expansion to accommodate an array of type III secretion systems (T3SSs). Strikingly, EBs orient with their T3SS-containing pole facing target cells, enabling the T3SSs to directly contact the cellular plasma membrane. This contact induces enveloping macropinosomes, actin-rich filopodia and phagocytic cups to zipper tightly around the internalising bacteria. Once encapsulated into tight early vacuoles, EB polarity and the T3SSs are lost. Our findings reveal previously undescribed structural transitions in both pathogen and host during the initial steps of chlamydial invasion

Three-Body Dynamics with Gravitational Wave Emission

We present numerical three-body experiments that include the effects of gravitational radiation reaction by using equations of motion that include the 2.5-order post-Newtonian force terms, which are the leading order terms of energy loss from gravitational waves. We simulate binary-single interactions and show that close approach cross sections for three 1 solar mass objects are unchanged from the purely Newtonian dynamics except for close approaches smaller than 1.0e-5 times the initial semimajor axis of the binary. We also present cross sections for mergers resulting from gravitational radiation during three-body encounters for a range of binary semimajor axes and mass ratios including those of interest for intermediate-mass black holes (IMBHs). Building on previous work, we simulate sequences of high-mass-ratio three-body encounters that include the effects of gravitational radiation. The simulations show that the binaries merge with extremely high eccentricity such that when the gravitational waves are detectable by LISA, most of the binaries will have eccentricities e > 0.9 though all will have circularized by the time they are detectable by LIGO. We also investigate the implications for the formation and growth of IMBHs and find that the inclusion of gravitational waves during the encounter results in roughly half as many black holes ejected from the host cluster for each black hole accreted onto the growing IMBH.Comment: 34 pages, 14 figures, minor corrections to match version accepted by Ap

The Structure of Global Attractors for Dissipative Zakharov Systems with Forcing on the Torus

The Zakharov system was originally proposed to study the propagation of Langmuir waves in an ionized plasma. In this paper, motivated by earlier work of the first and third authors, we numerically and analytically investigate the dynamics of the dissipative Zakharov system on the torus in 1 dimension. We find an interesting family of stable periodic orbits and fixed points, and explore bifurcations of those points as we take weaker and weaker dissipation.Comment: 16 pages, 7 figure

Lunar science from lunar laser ranging

Seventeen years of lunar ranging data have been analyzed to determine lunar second-degree moment differences, third-degree gravitational harmonics, Love number, rotational dissipation and retroreflector coordinates