Cell biology of ageing. IV. Effect of Nordihydro-guaiaretic acid (NDGA) and cortisone on the ageing syndromes of early senescent mutants of N. crassa.

Cell biology of ageing. IV. Effect of Nordihydro-guaiaretic acid (NDGA) and cortisone on the ageing syndromes of early senescent mutants of N. crassa

Sex hormones in Neurospora crassa. Spectrophotometric analysis cf the hormonal extracts of female sterile strains.

Sex hormones in Neurospora crassa. Spectrophotometric analysis cf the hormonal extracts of female sterile strains

Studi Fisikokimia Betasianin dalam Kulit Buah Naga dan Aplikasinya sebagai Pewarna Merah Alami Sediaan Farmasi: Physicochemical Study Of Betacyanin From Dragon Fruit Rind And Its Application AS Natural Dye For Pharmaceutical Dosage Form

The rind of dragon fruit (Hylocereus lemairel (Hook.) Britton & Rose) is a waste material that has not been optimally utilized. The rind contains betacyanin pigment that has many benefits in pharmaceutical products. The study aimed to characterize the physicochemical properties, to evaluate the stability and to apply betacyanin in dragon fruit rind as a natural dye. The extraction process was done by using water as solvent which was sonicated at 50 kHz for 30 minutes at 25 °C. Extract was freeze dried for 48 hours. The dried extract was purified by using preparative TLC and physicochemically analyzed by using UV-Vis and FTIR spectrophotometer. The stability of betacyanin extract against pH and temperature was examined and applied as a dye in tablet imprinting. The result of this study indicated that betacyanin was found at Rf value of 0.6 same as the betacyanin standard. The maximum wavelength of betacyanin was obtained at 534 nm and the IR spectra showed similarity with betacyanin standard with the same functional groups between 4000-600 cm-1 although there was a slight shift in the wavenumber but it still in the range. The stability study were stable at temperature below 40 °C and at range pH 4-6. Betacyanin applications as natural dye of tablet have been successfully carried out with good color stability during 3 months of storage at room temperature

Effect of mulching and organic manure on growth and yield performance of wheat

An experiment was conducted at the Agronomy Field Laboratory, Bangladesh Agricultural University, Mymensingh in Rabi season (dry season) of 2014 to study the effect of mulching and organic manure on growth and yield performance of wheat. Five mulching practices viz. M1=1 irrigation at 17-21 days after sowing (DAS), M2=2 irrigations at 17-21 and 55-60 DAS, M3=3 irrigations at 17-21, 55-60 and 75-80 DAS, M4=control, M5=straw mulch (6 t ha-1) and five organic manure managements viz. O1=recommended chemical fertilizer (NPKS @ 100-23-20-16 kg ha-1), O2=poultry manure @ 6 t ha-1 (100% PM), O3=vermicompost @ 8 t ha-1 (100% VC), O4=50% chemical fertilizer+50% VC and O5=50% chemical fertilizer+50% PM were used as experimental variables. The experiment was conducted in split-plot design with three replications. The results showed that mulching had significant influence on all attributes. The highest values of all attributes were found in straw mulch treatment. It was observed that organic manure had significant influences on all characters. The highest values of yield and yield attributes were found in O5 (50% chemical fertilizer+50% PM) treatment. It was observed that effective tillers hill-1, grain yield and straw yield were significantly affected by combined effect of mulching and organic manure. The highest values obtained from mulching and O5 (50% chemical fertilizer+50% PM) treatment. Therefore, it can be inferred from the results of the study that highest production could be obtained from mulching and O5 (50% chemical fertilizer+50% PM) treatment

Does Dysbiosis Play a Role in Age-Related Hearing Impairment?

Age-related hearing impairment (ARHI) is prevalent in older adults, affecting at least 60% of people by the time they reach 71 to 80 years of age.1 The number of people with ARHI will necessarily increase as humans live longer and a greater proportion of the population is older.2 Hearing loss does not just impact communication; it is associated with loneliness and depression, cognitive decline and dementia, as well as reduced physical well-being.3-6 A decade ago, an international report calculated that hearing loss cost Europe £213 billion annually.7 There is currently no effective drug treatment for hearing loss. Hearing aids (average cost £2,300/pair) are the most commonly prescribed ameliorative therapy, but uptake is low; and among those who obtain hearing aids, a high proportion do not use them or are dissatisfied with them. Hearing loss prevention is therefore of compelling necessity, and genetic studies will help us understand how and why people lose their hearing ability and will inform prevention strategies

Human papillomavirus genotype distribution among colposcopy diagnosed cervical precancerous lesions

Background: Cervical cancer (CC) is one of the primary causes of gynaecological cancer death. Cervical cancer is the fourth most frequent cancer worldwide, and it is the second most common cancer in Bangladesh. The stage of cervical cancer at diagnosis has a significant impact on survival. Cervical cancer mortality is high in Bangladesh due to late detection and limited management facilities. The aim of the study was to determine the pattern of human papillomavirus (HPV) genotype among colposcopy diagnosed cervical precancerous lesions. Methods: This cross-sectional study was conducted in the department of gynecological oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka. Total of 142 women attending the colposcopy clinic of BSMMU. Results: The mean age was found 38.7±7.3 years with a range from 30 to 60 years. 10 (7.0%) patients were found HPV 16 positive followed by 1 (0.7%) HPV 18, another hr-HPV 3 (2.1%), HPV 16 and other hr-HPV 3 (2.1%) and HPV 16, HPV 18 and other hr-HPV 1 (0.7%). Regarding colposcopy reports 99 (69.7%) patients had CIN I, 33 (23.7%) had CIN II and 10 (7.0%) had CIN III identification by colposcopy reports. 61 (43.0%) patients had CIN I followed by 15 (10.6%) had CIN II, 11 (7.7%) had CIN III, 7 (4.9%) had CIS, and 48 (33.8%) had normal or squamous metaplasia by histopathological reports. Conclusions: It can be concluded that among all the 14 hr-HPV genotype HPV 16 is more prevalent while HPV18 prevalence was very low in colposcopy diagnosed cervical precancer cases. The study revealed HPV16 was more common among high grade lesions

Participation in physical play and leisure : developing a theory- and evidence-based intervention for children with motor impairments

Peer reviewedPublisher PD

Hemodynamic-GUIDEd management of Heart Failure (GUIDE-HF)

In that study, incremental reductions in the PA pressures in the monitored arm were associated with both reduction in the frequency of HFH and improvements in health-related quality of life among patients with both preserved (HFpEF) and reduced ejection fraction (HFrEF).3,4 Additionally, hemodynamic-guided HF management in the subset of HFrEF patients treated with guideline-directed medical therapy (GDMT) was associated with a strong trend toward improved survival compared to traditional clinical management.4,7 Consistent benefit is demonstrated in several retrospective studies from the CHAMPION Trial.10-13 as well as extensive analysis of “real-world� experience.6,14 and in Medicare claims data managed in a commercial setting.5,15 Whether the benefits of PA pressure guided therapy can be extended to a broader pool of patients with milder (NYHA class II) or more severe (NYHA class IV) HF or to those without recent hospitalization for HF but with elevation in natriuretic peptide levels remains unclear. Remotely uploaded PA pressure information from the control group will be blocked from investigator review. [...]other than medication changes resulting from information from RHC procedures, control group subjects will not have pressure-based medication changes over time and should be managed instead according to routine practice as informed by published clinical guidelines. Thresholds for NT-proBNP/BNP corrected for BMI using a 4% reduction per BMI unit over 25 kg/m2 Subjects ≥18 y of age able and willing to provide informed consent Chest circumference of 15) at implant RHC, a history of noncompliance, or any condition that would preclude CardioMEMS PA Sensor implantation Table I Inclusion and exclusion criteria PA pressure goals PA diastolic: 8-20 mm Hg PA mean: 10-25 mm Hg PA systolic: 15-35 mm Hg Optimization phas