8 research outputs found
CD164 identifies CD4+ T cells highly expressing genes associated with malignancy in SĂ©zary syndrome: the SĂ©zary signature genes, FCRL3, Tox, and miR-214
- Author
- A Bensussan
- Adrienne Werth
- AF Huang
- Alain H. Rook
- AM Havens
- Andrea B. Troxel
- B Agrawal
- Bernice M. Benoit
- BO Dulmage
- Brian S. Kim
- BS Kim
- Christopher Miller
- Daniel W. McVicar
- E Ballabio
- E Begue
- E Coustan-Smith
- E Guenova
- E Guenova
- E Penna
- E Poszepczynska-Guigne
- E Scala
- EA Olsen
- EJ Kim
- F Leccia
- G Yin
- Geraldine OâConnor
- GF Murphy
- H Moins-Teisserenc
- HĂ©lĂšne Sicard
- IV Litvinov
- J Tang
- JJ Campbell
- JS Chung
- JS Chung
- Junko Takeshita
- K Ferenczi
- L Kari
- Landon K. Oetjen
- LC Showe
- Lisa Zhu
- M Goswami
- M Nebozhyn
- M Sokolowska-Wojdylo
- M Wysocka
- Maria Wysocka
- MG Narducci
- N Yawalkar
- Neha Jariwala
- P Aliahmad
- PT Jindra
- R van Doorn
- S Jain
- S Morimura
- S Nagata
- SE Boonk
- SM Watt
- T Matsui
- Timothy M. Whelan
- WD Merritt
- Y Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 12/10/2016
- Field of study
SĂ©zary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), is associated with a significantly shorter life expectancy compared to skin-restricted mycosis fungoides. Early diagnosis of SS is, therefore, key to achieving enhanced therapeutic responses. However, the lack of a biomarker(s) highly specific for malignant CD4+ T cells in SS patients has been a serious obstacle in making an early diagnosis. We recently demonstrated the high expression of CD164 on CD4+ T cells from SĂ©zary syndrome patients with a wide range of circulating tumor burdens. To further characterize CD164 as a potential biomarker for malignant CD4+ T cells, CD164+ and CD164-CD4+ T cells isolated from patients with high-circulating tumor burden, B2 stage, and medium/low tumor burden, B1-B0 stage, were assessed for the expression of genes reported to differentiate SS from normal controls, and associated with malignancy and poor prognosis. The expression of SĂ©zary signature genes: T plastin, GATA-3, along with FCRL3, Tox, and miR-214, was significantly higher, whereas STAT-4 was lower, in CD164+ compared with CD164-CD4+ T cells. While Tox was highly expressed in both B2 and B1-B0 patients, the expression of SĂ©zary signature genes, FCRL3, and miR-214 was associated predominantly with advanced B2 disease. High expression of CD164 mRNA and protein was also detected in skin from CTCL patients. CD164 was co-expressed with KIR3DL2 on circulating CD4+ T cells from high tumor burden SS patients, further providing strong support for CD164 as a disease relevant surface biomarker
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
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- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
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- Ajith Parameswaran
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- ĂrpĂĄd Gergely LĂĄszlĂł
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- Vahlbruch Henning
- Vajente Gabriele
- Valdes Guillermo
- Valentini Michele
- Vallisneri M.
- van Bakel Niels
- van Beuzekom Martin
- van den Br
- Van den Broeck Chris
- van der Schaaf Laura
- Van Heijningen Joris V.
- van Veggel Marielle A.
- Vardaro Marco
- Varma Vijay
- Vass Steve
- Vasuth Matyas
- Vecchio Alberto
- Vedovato Gabriele
- Veitch John
- Veitch Peter J.
- Venkateswara Krishna
- Venugopalan Gautam
- Verkindt Didier
- Veske Doga
- Vetrano Flavio
- Vicere Andrea
- Viets Aaron D.
- Villa Elena Mejuto
- Vinciguerra Serena
- Vine David J.
- Vinet Jeanyves
- Virgo Collaboration
- Vitale Salvatore
- Vivanco Francisco Hern
- Vo Thomas
- Vocca Helios
- Vorvick Cheryl
- Vyatchanin Sergey P.
- Wade Andrew R.
- Wade Leslie E.
- Wade Madeline
- Walet Rob
- Walker Marissa
- Wallace Gavin S.
- Wallace Larry
- Walsh Sinead
- Wang Jonathan Z.
- Wang Sibo
- Wang Wenhui H.
- Wang Yifan F.
- Ward Robert L.
- Warden Zane A.
- Warner Jim
- Was Michal
- Watchi Jennifer
- Weaver Betsy
- Wei Li-wei
- Weinert Michael
- Weinstein Alan J.
- Weiss Rainer
- Wellmann Felix
- Wen Linqing
- Wessels Peter
- Westhouse Jonathan W.
- Wette Karl
- Whelan John T.
- Whiting Bernard F.
- Whittle Chris
- Wilken Dennis M.
- Williams Daniel
- Williams Roy D.
- Williamson Andrew R.
- Willis Joshua L.
- Willke Benno
- Winkler Walter
- Wipf Christopher C.
- Wittel Holger
- Woan Graham
- Woehler Janis
- Wofford Jared K.
- Wong Chun-fung
- Wright Jennifer L.
- Wu David S.
- Wysocki Daniel M.
- Xiao Liting
- y J.
- Yamamoto Hiro
- Yang Le
- Yang Yang
- Yang Ziyan
- Yap Min-jet J.
- Yazback Maher
- Yeeles David W.
- Yiqiu Ma
- Yu Hang
- Yu Haocun
- Yuen Shingheirobin
- Zadrozny Adam
- Zadrozny Adam K.
- Zanolin Michele
- Zelenova Tatiana
- Zendri Jean-pierre
- Zevin Michael
- Zhang Jue
- Zhang Liyuan
- Zhang Teng
- Zhao Chunnong
- Zhao Guoying
- Zhou Minchuan
- Zhou Zifan
- Zhu Xingjiang J.
- Zimmerman Aaron B.
- Zucker Michael E.
- Zweizig John
- Publication venue
- 'Elsevier BV'
- Publication date
- 25/12/2019
- Field of study
Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software
Search for intermediate-mass black hole binaries in the third observing run of Advanced LIGO and Advanced Virgo
- Author
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adhikari Naresh
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Agarwal Deepali
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain Anirban
- Ajith P.
- Akutsu Tomotada
- Albanesi Simone
- Allocca Annalisa
- Altin Paul A.
- Amato Alex
- Anand Chandana
- Anand Shreya
- Ananyeva Alena
- Anderson Stuart B.
- Anderson Warren G.
- Ando Masaki
- Andrade Tomas
- Andres Nicolas
- AndriÄ Tomislav
- Angelova Svetoslava V.
- Ansoldi Stefano
- Antelis J.M.
- Antier Sarah
- Appert Stephen
- Arai Koji
- Arai Koya
- Arai Yuya
- Araki Sakae
- Araya Akito
- Araya Melody C.
- Areeda Joseph S.
- Arellano Fabian E. Peña
- Aritomi Naoki
- Arnaud Nicolas
- Aronson Scott M.
- Arun Kg G.
- ArĂšne Marc
- Asada Hideki
- Asali Yasmeen
- Ashton Gregory
- Aso Yoichi
- Assiduo Maria
- Aston Stuart M.
- Astone Pia
- Aubin Florian
- Austin Corey
- Babak Stanislav
- Badaracco Francesca
- Bader Maria K.M.
- Badger Charles
- Bae Sangwook
- Bae Y.
- Baer Anne M.
- Bagnasco Stefano
- Bai Yuntao
- Baiotti Luca
- Baird Jonathon
- Bajastani L.M. Daneshgaran
- Bajpai Rishabh
- Ball Matthew
- Ballardin Giulio
- Ballmer Stefan W.
- Balsamo Alexander
- Baltus Gregory
- Banagiri Sharan
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- Barbieri Claudio
- Barish Barry C.
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- Wofford Jared K.
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- Wu David S.
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- Wysocki Daniel M.
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- Xu W-R.
- Yamada Tomohiro
- Yamamoto Hiro
- Yamamoto Kazuhiro
- Yamamoto Kohei
- Yamamoto Takahiro
- Yamashita Kanta
- Yamazaki Ryo
- Yang Fengwei W.
- Yang Le
- Yang Yang
- Yang Yi
- Yang Ziyan
- Yap M.J.
- Yeeles David W.
- Yelikar Anjali B.
- Ying Make
- Yokogawa Kazuya
- Yokoyama J.
- Yokozawa Takaaki
- Yoo Jooheon
- Yoshioka Toshiya
- Yu Hang
- Yu Haocun
- Yuzurihara Hirotaka
- ZadroĆŒny Adam
- Zanolin Michele
- Zeidler Simon
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhan Mingsheng
- Zhang Hong
- Zhang Jue
- Zhang Liyuan
- Zhang Teng
- Zhang Yanqi
- Zhao Chunnong
- Zhao Guoying
- Zhao Yue
- Zhao Yuhang
- Zhou Ruinan
- Zhou Zifan
- Zhu Xingjiang J.
- Zhu Z.-H.
- Zimmerman Aaron B.
- Zlochower Y.
- Zucker Michael E.
- Zweizig John
- Publication venue
- 'EDP Sciences'
- Publication date
- 01/01/2022
- Field of study
International audienceIntermediate-mass black holes (IMBHs) span the approximate mass range 100â105âMâ, between black holes (BHs) that formed by stellar collapse and the supermassive BHs at the centers of galaxies. Mergers of IMBH binaries are the most energetic gravitational-wave sources accessible by the terrestrial detector network. Searches of the first two observing runs of Advanced LIGO and Advanced Virgo did not yield any significant IMBH binary signals. In the third observing run (O3), the increased network sensitivity enabled the detection of GW190521, a signal consistent with a binary merger of mass âŒ150âMâ providing direct evidence of IMBH formation. Here, we report on a dedicated search of O3 data for further IMBH binary mergers, combining both modeled (matched filter) and model-independent search methods. We find some marginal candidates, but none are sufficiently significant to indicate detection of further IMBH mergers. We quantify the sensitivity of the individual search methods and of the combined search using a suite of IMBH binary signals obtained via numerical relativity, including the effects of spins misaligned with the binary orbital axis, and present the resulting upper limits on astrophysical merger rates. Our most stringent limit is for equal mass and aligned spin BH binary of total mass 200âMâ and effective aligned spin 0.8 at 0.056 Gpcâ3 yrâ1 (90% confidence), a factor of 3.5 more constraining than previous LIGO-Virgo limits. We also update the estimated rate of mergers similar to GW190521 to 0.08 Gpcâ3 yrâ1.Key words: gravitational waves / stars: black holes / black hole physicsCorresponding author: W. Del Pozzo, e-mail: [email protected]â Deceased, August 2020