Clinically and radiologically successful treatment of spondylitis by guselkumab in a patient with pustulotic arthro‐osteitis

This article reported the first case of spondylitis due to pustulotic arthro‐osteitis that was successfully treated with anti‐IL‐23p19 antibody guselkumab in terms of improvement in imaging assessment in addition to that of clinical symptoms

The harmful side of expressing thanks: Re-examining the Study 2 by Ksenofontov and Becker (2020)

This study re-examined the results of Study 2 by Ksenofontov and Becker (2020) that revealed the harmful effects of expressing thanks by low-power group members to a high-power group member who transgressed and then did them a favor, which resulted in undermining the low-power group members’ protest intentions. They also found a mediating effect of forgiveness; expressing thanks functions as an act of forgiveness, which lowers the intention to protest. Contrary to their results, we did not find any significant effects of expressing thanks on protest intentions or forgiveness in either of the two hypothetical scenarios. The original study involved participants from German universities, whereas the present study was conducted on Japanese students. Therefore, the cultural difference in expressing gratitude could have been a factor in the contrasting results.本研究はJPSP科研費21K02978の助成を受けた

Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion

Abstract Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available in vitro sandwich-cultured hepatocyte method is cumbersome because drugs accumulate in the closed bile canalicular lumen formed between hepatocytes and their amounts cannot be mealsured directly. This study proposes a hepatocyte culture model for the rapid evaluation of drug biliary excretion using permeation assays. When hepatocytes are cultured on a permeable support coated with the cell adhesion protein claudins, an open-form bile canalicular lumen is formed at the surface of the permeable support. Upon application to the basolateral (blood) side, drugs appear on the bile canalicular side. The biliary excretion clearance of several drugs, as estimated from the obtained permeabilities, correlates well with the reported in vivo biliary excretion clearance in humans. Thus, the established model is useful for applications in the efficient evaluation of biliary excretion during drug discovery and development

Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat

The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased