Salience, Imagination, and Moral Luck

One key desideratum of a theory of blame is that it be able to explain why we typically have differing blaming responses in cases involving significant degrees of luck. T.M. Scanlon has proposed a relational account of blame, and he has argued that his account succeeds in this regard and that this success makes his view preferable to reactive attitude accounts of blame. In this paper, I aim to show that Scanlon's view is open to a different kind of luck-based objection. I then offer a way of understanding moral luck cases which allows for a plausible explanation of our differential blaming responses by appealing to the salience of certain relevant features of the action in question

A Mixed Judgment Standard of Surrogate Decision Making

The Substituted Judgment Standard (SJS) for surrogate decision-making dictates that a surrogate, when making medical decisions on behalf of an incapacitated patient, ought to make the decision that the patient would have made if the patient had decisional capacity. Despite its intuitive appeal, however, SJS has been the target of a variety of criticisms. Most objections to SJS appeal to epistemic difficulties involved in determining what a patient would have decided in a given case. In this paper, I offer an alternative standard for surrogate decision-making that avoids these difficulties. I then offer an account of its theoretical underpinnings which shows that it preserves the central moral justification for SJS, namely, respect for patient autonomy

Autism, episodic memory, and moral exemplars

This paper presents a challenge for exemplar theories of moral concepts. Some have proposed that we acquire moral concepts by way of exemplars of actions that are prohibited as well as of actions that are required, and we classify newly encountered actions based on their similarity to these exemplars. Judgments of permissibility then follow from these exemplar-based classifications. However, if this were true, then we would expect that individuals who lacked, or were deficient in, the capacity to form or access exemplars of this kind would be similarly deficient in the ability to classify new actions according to them, and this relative inability would be manifested in the moral judgments made by such individuals. However, there is reason to suspect, I think, that a number of individuals who have been diagnosed with Autism Spectrum Disorder actually have the deficiencies I have described here but are nevertheless fully able to make sound moral judgments. If this is so, then it must be th..

The Buck Stops There: The Impact of Perceived Accountability and Control on the Intention to Delegate to Software Agents

Software agents with the ability to recommend actions, aid decision-making, and actually make decisions are becoming increasingly common. In many situations, users now choose whether or not to delegate tasks to these agents. While some research has examined software agents, relatively little is known about the factors that influence the intention to delegate decisions to them. An experiment was used to examine the influence of perceived accountability, extent of control, and trust in the agent on the intention to delegate a travel arrangement decision. Users were more likely to delegate to agents that gave them greater control by requiring them to approve the agent’s recommendation before the decision was completed than to agents that performed the task autonomously without intervention after it was delegated. Contrary to expectations, intention to delegate increased as perceived accountability increased. Participants may perceive delegation as a means to shift blame from themselves to the agent and thus mitigate risk resulting from potential negative decision outcomes

The L3 Neuron and an Associated Prothoracic Network are Involved in Calling Song Recognition by Female Crickets

In young virgin Acheta domesticus females, the spiking response of the prothoracic L3 auditory interneuron discriminates between calling songs (CSs) with phonotactically attractive and unattractive syllable periods (SPs), which parallels phonotactic discrimination. Presentation of a CS with an originally attractive SP, but with the intensity modulated so as to minimize L3\u27s selective response, results in a CS with little phonotactic attractiveness. Conversely, a CS with an originally unattractive SP becomes much more attractive when the CS is intensity modulated in ways that duplicate L3\u27s selective response. L3\u27s discriminatory response to CS SP deteriorates with age, in parallel with decreased phonotactic selectiveness (females, older than 14 days, typically are unselective for CS SPs). SP-selective processing, which was not apparent in these old L3s, is immediately restored by removing the contralateral ear. SP-specific information is resident in a network of neurons within the prothoracic ganglion that results in the SP selective responses of the L3 neuron in young females. Changes in the SP-selective responses of the L3 neuron are highly correlated with corresponding changes in the female\u27s phonotactically selective behavior

Normalization of Sequential Top-Down Tree-to-Word Transducers

International audienceWe study normalization of deterministic sequential top-down tree-to-word transducers (STWs), that capture the class of deterministic top-down nested-word to word transducers. We identify the subclass of earliest STWs (eSTWs) that yield normal forms when minimized. The main result of this paper is an effective normalization procedure for STWs. It consists of two stages: we first convert a given STW to an equivalent eSTW, and then, we minimize the eSTW. Keywords: formal language theory, tree automata, transformations, XML databases, XSLTExtended Version: A long version is available here.</p

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease onset and progression due to declines in adipogenesis with advancing age. Recent reports indicate that the accumulation of senescent progenitor cells may be involved in age-related WAT dysfunction. Growth hormone (GH) action has profound effects on adiposity and metabolism and is known to influence lifespan. In the present study we tested the hypothesis that GH activity would predict age-related WAT dysfunction and accumulation of senescent cells. We found that long-lived GH-deficient and -resistant mice have reduced age-related lipid redistribution. Primary preadipocytes from GH-resistant mice also were found to have greater differentiation capacity at 20 months of age when compared to controls. GH activity was also found to be positively associated with senescent cell accumulation in WAT. Our results demonstrate an association between GH activity, age-related WAT dysfunction, and WAT senescent cell accumulation in mice. Further studies are needed to determine if GH is directly inducing cellular senescence in WAT or if GH actions on other target organs or alternative downstream alterations in insulin-like growth factor-1, insulin or glucose levels are responsible

Transplant Acceptance Following Anti-CD4 Versus Anti-CD40L Therapy: Evidence for Differential Maintenance of Graft-Reactive T Cells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73145/1/j.1600-6143.2008.02372.x.pd