A new and unusual LBV-like outburst from a Wolf–Rayet star in the outskirts of M33

MCA-1B (also called UIT003) is a luminous hot star in the western outskirts of M33, classified over 20 yr ago with a spectral type of Ofpe/WN9 and identified then as a candidate luminous blue variable (LBV). Palomar Transient Factory data reveal that this star brightened in 2010, with a light curve resembling that of the classic LBV star AF And in M31. Other Ofpe/WN9 stars have erupted as LBVs, but MCA-1B was unusual because it remained hot. It showed a WN-type spectrum throughout its eruption, whereas LBVs usually get much cooler. MCA-1B showed an almost four-fold increase in bolometric luminosity and a doubling of its radius, but its temperature stayed ≳29 kK. As it faded, it shifted to even hotter temperatures, exhibiting a WN7/WN8-type spectrum, and doubling its wind speed. MCA-1B is reminiscent of some supernova impostors, and its location resembles the isolated environment of SN 2009ip. It is most similar to HD 5980 (in the Small Magellanic Cloud) and GR 290 (also in M33). Whereas these two LBVs exhibited B-type spectra in eruption, MCA-1B is the first clear case where a Wolf–Rayet (WR) spectrum persisted at all times. Together, MCA-1B, HD 5980, and GR 290 constitute a class of WN-type LBVs, distinct from S Doradus LBVs. They are most interesting in the context of LBVs at low metallicity, a possible post-LBV/WR transition in binaries, and as likely Type Ibn supernova progenitors

Antibiotics in childhood pneumonia: how long is long enough?

Improved access to healthcare, vaccines and treatment with antibiotics has reduced global mortality from childhood community-acquired pneumonia. However, as respiratory viruses are responsible for most episodes of pneumonia, important questions remain over who should receive these agents and the length of each treatment course. Worldwide concerns with increasing antibiotic resistance in respiratory pathogens and appeals for more prudent antibiotic prescribing provide further urgency to these clinical questions. Unfortunately, guidelines for treatment duration in particular are based upon limited (and often weak) evidence, resulting in national and international guidelines recommending treatment courses for uncomplicated pneumonia ranging from 3 to 10 days. The advantages of shortcourse therapy include a lower risk of developing antibiotic resistance, improved adherence, fewer adverse drug effects, and reduced costs. The risks include treatment failure, leading to increased short- or long-term morbidity, or even death. The initial challenge is how to distinguish between bacterial and non-bacterial causes of pneumonia and then to undertake adequately powered randomised-controlled trials of varying antibiotic treatment durations in children who are most likely to have bacterial pneumonia. Meanwhile, healthcare workers should recognise the limitations of current pneumonia treatment guidelines and remember that antibiotic course duration is also determined by the child’s response to therapy

A new and unusual LBV-like outburst from a Wolf–Rayet star in the outskirts of M33

MCA-1B (also called UIT003) is a luminous hot star in the western outskirts of M33, classified over 20 yr ago with a spectral type of Ofpe/WN9 and identified then as a candidate luminous blue variable (LBV). Palomar Transient Factory data reveal that this star brightened in 2010, with a light curve resembling that of the classic LBV star AF And in M31. Other Ofpe/WN9 stars have erupted as LBVs, but MCA-1B was unusual because it remained hot. It showed a WN-type spectrum throughout its eruption, whereas LBVs usually get much cooler. MCA-1B showed an almost four-fold increase in bolometric luminosity and a doubling of its radius, but its temperature stayed ≳29 kK. As it faded, it shifted to even hotter temperatures, exhibiting a WN7/WN8-type spectrum, and doubling its wind speed. MCA-1B is reminiscent of some supernova impostors, and its location resembles the isolated environment of SN 2009ip. It is most similar to HD 5980 (in the Small Magellanic Cloud) and GR 290 (also in M33). Whereas these two LBVs exhibited B-type spectra in eruption, MCA-1B is the first clear case where a Wolf–Rayet (WR) spectrum persisted at all times. Together, MCA-1B, HD 5980, and GR 290 constitute a class of WN-type LBVs, distinct from S Doradus LBVs. They are most interesting in the context of LBVs at low metallicity, a possible post-LBV/WR transition in binaries, and as likely Type Ibn supernova progenitors

How Sales Taxes Affect Customer and Firm Behavior: The Role of Search on the Internet

When a multichannel retailer opens its first retail store in a state, the firm is obligated to collect sales taxes on all Internet and catalog orders shipped to that state. This article assesses how opening a store affects Internet and catalog demand. The authors analyze purchase behavior among customers who live far from the retail store but must now pay sales taxes on catalog and Internet purchases. A comparable group of customers in a neighboring state serves as a control. The results show that Internet sales decrease significantly, but catalog sales are unaffected. Further investigation indicates that the difference in these outcomes is partly attributable to the ease with which customers can search for lower prices at competing retailers. The authors extend the analysis to a panel of multichannel firms and show that retailers that earn a large proportion of their revenue from direct channels avoid opening a first store in high-tax states. They conclude that current U.S. sales taxes laws have significant effects on both customer and firm behavior

Systemic immunity is required for effective cancer immunotherapy

Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass cytometry. We analyzed immune responses in several tissues after immunotherapy by developing intuitive models for visualizing single-cell data with statistical inference. Immune activation was evident in the tumor and systemically shortly after effective therapy was administered. However, during tumor rejection, only peripheral immune cells sustained their proliferation. This systemic response was coordinated across tissues and required for tumor eradication in several immunotherapy models. An emergent population of peripheral CD4 T cells conferred protection against new tumors and was significantly expanded in patients responding to immunotherapy. These studies demonstrate the critical impact of systemic immune responses that drive tumor rejection

GRB 180418A:A Possibly Short Gamma-Ray Burst with a Wide-angle Outflow in a Faint Host Galaxy

We present X-ray and multiband optical observations of the afterglow and host galaxy of GRB 180418A, discovered by Swift/BAT and Fermi/GBM. We present a reanalysis of the GBM and BAT data deriving durations of the prompt emission of T 90 ≈ 2.56 and 1.90 s, respectively. Modeling the Fermi/GBM catalog of 1405 bursts (2008-2014) in the hardness-T 90 plane, we obtain a probability of ≈60% that GRB 180418A is a short-hard burst. From a combination of Swift/XRT and Chandra observations, the X-ray afterglow is detected to ≈38.5 days after the burst and exhibits a single power-law decline with F X ∝ t -0.98. Late-time Gemini observations reveal a faint r ≈ 25.69 mag host galaxy at an angular offset of ≈0.″16. At the likely redshift range of z ≈ 1-2.25, we find that the X-ray afterglow luminosity of GRB 180418A is intermediate between short and long gamma-ray bursts (GRBs) at all epochs during which there are contemporaneous data and that GRB 180418A lies closer to the E γ,peak-E γ,iso correlation for short GRBs. Modeling the multiwavelength afterglow with the standard synchrotron model, we derive the burst explosion properties and find a jet opening angle of θ j 9°-14°. If GRB 180418A is a short GRB that originated from a neutron star merger, it has one of the brightest and longest-lived afterglows along with an extremely faint host galaxy. If, instead, the event is a long GRB that originated from a massive star collapse, it has among the lowest-luminosity afterglows and lies in a peculiar space in terms of the hardness-T 90 and E γ,peak-E γ,iso planes. © 2021. The American Astronomical Society. All rights reserved..Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

GRB 180418A:A Possibly Short Gamma-Ray Burst with a Wide-angle Outflow in a Faint Host Galaxy

We present X-ray and multiband optical observations of the afterglow and host galaxy of GRB 180418A, discovered by Swift/BAT and Fermi/GBM. We present a reanalysis of the GBM and BAT data deriving durations of the prompt emission of T 90 ≈ 2.56 and 1.90 s, respectively. Modeling the Fermi/GBM catalog of 1405 bursts (2008-2014) in the hardness-T 90 plane, we obtain a probability of ≈60% that GRB 180418A is a short-hard burst. From a combination of Swift/XRT and Chandra observations, the X-ray afterglow is detected to ≈38.5 days after the burst and exhibits a single power-law decline with F X ∝ t -0.98. Late-time Gemini observations reveal a faint r ≈ 25.69 mag host galaxy at an angular offset of ≈0.″16. At the likely redshift range of z ≈ 1-2.25, we find that the X-ray afterglow luminosity of GRB 180418A is intermediate between short and long gamma-ray bursts (GRBs) at all epochs during which there are contemporaneous data and that GRB 180418A lies closer to the E γ,peak-E γ,iso correlation for short GRBs. Modeling the multiwavelength afterglow with the standard synchrotron model, we derive the burst explosion properties and find a jet opening angle of θ j 9°-14°. If GRB 180418A is a short GRB that originated from a neutron star merger, it has one of the brightest and longest-lived afterglows along with an extremely faint host galaxy. If, instead, the event is a long GRB that originated from a massive star collapse, it has among the lowest-luminosity afterglows and lies in a peculiar space in terms of the hardness-T 90 and E γ,peak-E γ,iso planes. </p

A Neutralizing Monoclonal Antibody Targeting the Acid-Sensitive Region in Chikungunya Virus E2 Protects from Disease.

The mosquito-borne alphavirus, chikungunya virus (CHIKV), has recently reemerged, producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute and chronic rheumatic disease. There are currently no licensed vaccines for CHIKV and current anti-inflammatory drug treatment is often inadequate. Here we describe the isolation and characterization of two human monoclonal antibodies, C9 and E8, from CHIKV infected and recovered individuals. C9 was determined to be a potent virus neutralizing antibody and a biosensor antibody binding study demonstrated it recognized residues on intact CHIKV VLPs. Shotgun mutagenesis alanine scanning of 98 percent of the residues in the E1 and E2 glycoproteins of CHIKV envelope showed that the epitope bound by C9 included amino-acid 162 in the acid-sensitive region (ASR) of the CHIKV E2 glycoprotein. The ASR is critical for the rearrangement of CHIKV E2 during fusion and viral entry into host cells, and we predict that C9 prevents these events from occurring. When used prophylactically in a CHIKV mouse model, C9 completely protected against CHIKV viremia and arthritis. We also observed that when administered therapeutically at 8 or 18 hours post-CHIKV challenge, C9 gave 100% protection in a pathogenic mouse model. Given that targeting this novel neutralizing epitope in E2 can potently protect both in vitro and in vivo, it is likely to be an important region both for future antibody and vaccine-based interventions against CHIKV

Concurrent photocatalytic degradation of organic contaminants and photocathodic protection of steel Ag–TiO2 composites

The final publication is available at Elsevier via https://dx.doi.org/10.1016/j.mtla.2018.08.033 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/In this study, coupled titanium dioxide-silver composite and steel electrode pairs were investigated for their use in cathodic protection under illuminated and dark conditions to prevent corrosion and enhance contaminant degradation under photocatalysis. A series of photoelectrochemical tests were used to determine the properties of the photoanode and identify the cathodic protection behaviour in the presence and absence of organic/inorganic contaminants. Additionally, corrosion-prone steel was used to test the principle of photocathodic protection in reducing oxide formation and mass loss under base metal and welded materials.Natural Sciences and Engineering Research Council of Canada [STPG-494554-2016]Schwartz-Reisman Foundation through the Waterloo Institute of Nanotechnology − Technion University gran

A new and unusual LBV-like outburst from a Wolf-Rayet star in the outskirts of M33

MCA-1B (also called UIT003) is a luminous hot star in the western outskirts of M33, classified over 20yr ago with a spectral type of Ofpe/WN9 and identified then as a candidate luminous blue variable (LBV). Palomar Transient Factory data reveal that this star brightened in 2010, with a light curve resembling that of the classic LBV star AFAnd in M31. Other Ofpe/WN9 stars have erupted as LBVs, but MCA-1B was unusual because it remained hot. It showed a WN-type spectrum throughout its eruption, whereas LBVs usually get much cooler. MCA-1B showed an almost four-fold increase in bolometric luminosity and a doubling of its radius, but its temperature stayed around 29kK. As it faded, it shifted to even hotter temperatures, exhibiting a WN7/WN8-type spectrum, and doubling its wind speed. MCA-1B is reminiscent of some supernova impostors, and its location resembles the isolated environment of SN 2009ip. It is most similar to HD5980 (in the SMC) and GR 290 (also in M33). Whereas these two LBVs exhibited B-type spectra in eruption, MCA-1B is the first clear case where a Wolf-Rayet (WR) spectrum persisted at all times. Together, MCA-1B, HD 5980, and GR 290 constitute a class of WN-type LBVs, distinct from S Doradus LBVs. They are most interesting in the context of LBVs at low metallicity, a possible post-LBV/WR transition in binaries, and as likely Type~Ibn supernova progenitors.Comment: accepted in MNRAS. 20 pages, 15 figure