397 research outputs found
Nonlinear filtering for Markov systems with delayed observations
Versione iniziale di un lavoro successivamente pubblicato
(altra versione disponible su)
http://www.mat.uniroma1.it/people/nappo/papers.pdf/CFN-JAMCS-DelayMarkov.pd
How should eosinophilic cystitis be treated in patients with chronic granulomatous disease?
Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from the absence or malfunction of oxidative mechanism in phagocytic cells. The disease is due to a mutation in one of four genes that encode subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Affected patients experience severe infections and granuloma formation due to exuberant inflammatory responses. Some evidence suggests that eosinophilic cystitis (EC) is included in the spectrum of inflammatory manifestations. EC is an inflammatory disease, rare in childhood, which may require different, nonstandardized therapeutic approaches, ranging from antihistamines to cyclosporine
Unveiling the population of orphan Gamma Ray Bursts
Gamma Ray Bursts are detectable in the gamma-ray band if their jets are
oriented towards the observer. However, for each GRB with a typical theta_jet,
there should be ~2/theta_jet^2 bursts whose emission cone is oriented elsewhere
in space. These off-axis bursts can be eventually detected when, due to the
deceleration of their relativistic jets, the beaming angle becomes comparable
to the viewing angle. Orphan Afterglows (OA) should outnumber the current
population of bursts detected in the gamma-ray band even if they have not been
conclusively observed so far at any frequency. We compute the expected flux of
the population of orphan afterglows in the mm, optical and X-ray bands through
a population synthesis code of GRBs and the standard afterglow emission model.
We estimate the detection rate of OA by on-going and forthcoming surveys. The
average duration of OA as transients above a given limiting flux is derived and
described with analytical expressions: in general OA should appear as daily
transients in optical surveys and as monthly/yearly transients in the mm/radio
band. We find that ~ 2 OA yr^-1 could already be detected by Gaia and up to 20
OA yr^-1 could be observed by the ZTF survey. A larger number of 50 OA yr^-1
should be detected by LSST in the optical band. For the X-ray band, ~ 26 OA
yr^-1 could be detected by the eROSITA. For the large population of OA
detectable by LSST, the X-ray and optical follow up of the light curve (for the
brightest cases) and/or the extensive follow up of their emission in the mm and
radio band could be the key to disentangle their GRB nature from other
extragalactic transients of comparable flux density.Comment: 9 pages, 4 figures, 2 tables. Accepted for publication by Astronomy
and Astrophysic
FFAs and QT intervals in obese women with visceral adiposity: Effects of sustained weight loss over 1 year
We evaluated 66 obese patients grouped by waist-to-hip ratio (WHR) into group A (WHR > 0.85, n = 30) and group B (WHR ≤ 0.85, n = 36), before and after 1 yr of diet-induced weight loss compared with 25 nonobese women. Before diet, the longest values of QT intervals and the highest levels of FFA and catecholamines were in group A (P < 0.01). In obese women (both groups), the corrected QT (QTc); interval correlated with plasma FFA (P < 0.01) and catecholamine (P < 0.02) concentrations. After 1 yr of diet, at the same levels of body weight reduction, the decrement of the QTc interval (P < 0.02), FFA (P < 0.01) and catecholamine (P < 0.02) levels were significantly greater in-group A than group B. In multivariate analysis, the decline of the QTc interval after weight loss was associated with changes in plasma FFA independently of changes in WHR and plasma catecholamines. Our data suggest that the QTc interval is tightly correlated with plasma FFA levels; shortening of cardiac repolarization times in the course of long-lasting weight reduction may reduce the risk of ventricular electrical instability, especially in women with abdominal adiposity
Short GRBs at the dawn of the gravitational wave era
We derive the luminosity function and redshift distribution of short Gamma
Ray Bursts (SGRBs) using (i) all the available observer-frame constraints (i.e.
peak flux, fluence, peak energy and duration distributions) of the large
population of Fermi SGRBs and (ii) the rest-frame properties of a complete
sample of Swift SGRBs. We show that a steep with a>2.0
is excluded if the full set of constraints is considered. We implement a Monte
Carlo Markov Chain method to derive the and functions
assuming intrinsic Ep-Liso and Ep-Eiso correlations or independent
distributions of intrinsic peak energy, luminosity and duration. To make our
results independent from assumptions on the progenitor (NS-NS binary mergers or
other channels) and from uncertainties on the star formation history, we assume
a parametric form for the redshift distribution of SGRBs. We find that a
relatively flat luminosity function with slope ~0.5 below a characteristic
break luminosity ~3 erg/s and a redshift distribution of SGRBs
peaking at z~1.5-2 satisfy all our constraints. These results hold also if no
Ep-Liso and Ep-Eiso correlations are assumed. We estimate that, within ~200 Mpc
(i.e. the design aLIGO range for the detection of GW produced by NS-NS merger
events), 0.007-0.03 SGRBs yr should be detectable as gamma-ray events.
Assuming current estimates of NS-NS merger rates and that all NS-NS mergers
lead to a SGRB event, we derive a conservative estimate of the average opening
angle of SGRBs: ~3-6 deg. Our luminosity function implies an
average luminosity L~1.5 erg/s, nearly two orders of magnitude
higher than previous findings, which greatly enhances the chance of observing
SGRB "orphan" afterglows. Efforts should go in the direction of finding and
identifying such orphan afterglows as counterparts of GW events.Comment: 13 pages, 5 figures, 2 tables. Accepted for publication in Astronomy
& Astrophysics. Figure 5 and angle ranges corrected in revised versio
The high-redshift gamma-ray burst GRB140515A
High-redshift gamma-ray bursts have several advantages for the study of the
distant universe, providing unique information about the structure and
properties of the galaxies in which they exploded. Spectroscopic identification
with large ground-based telescopes has improved our knowledge of the class of
such distant events. We present the multi-wavelength analysis of the high-
Swift gamma-ray burst GRB140515A (). The best estimate of the
neutral hydrogen fraction of the intergalactic medium (IGM) towards the burst
is . The spectral absorption lines detected for this event
are the weakest lines ever observed in gamma-ray burst afterglows, suggesting
that GRB140515A exploded in a very low density environment. Its circum-burst
medium is characterised by an average extinction (A) that
seems to be typical of events. The observed multi-band light curves
are explained either with a very flat injected spectrum () or with a
multi-component emission (). In the second case a long-lasting central
engine activity is needed in order to explain the late time X-ray emission. The
possible origin of GRB140515A from a Pop III (or from a Pop II stars with local
environment enriched by Pop III) massive star is unlikely.Comment: 10 pages, 8 figures, 5 tables, submitted to Astronomy & Astrophysic
Immune infiltrating cells in duodenal cancers
Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered a thorough understanding of the pathogenesis of the disease and of its biology, limiting the identification of tailored therapeutic options. A large body of evidence has clearly shown the clinical relevance of immune cells in solid tumors, correlating immune features with post-surgical prognosis. The aim of this study was to analyze the immune contexture in a cohort of duodenal adenocarcinomas surgically resected at our Institution and define its correlation with clinical variables.
Methods
Tissue slides from paraffin-embedded tumor specimens of 15 consecutive DA and 3 adenomas that underwent a pancreaticoduodenectomy in our center between 2010 to 2018 were immunohistochemically stained. The density (percentage of immune reactive area, IRA%) of immune markers CD45RO, CD8, CD20, IL-17, PD-1, CD68 was quantified by computer-assisted image analysis. Demographic, clinical, histopathological data were collected.
Results
In our population, median IRA % (IQR) of immune subsets was respectively CD45RO-TILs 2.19 (2.14), CD8-TIL 0.42 (0.81), CD20-TILs 0.22 (0.51), CD20-TLT 2.84 (4.64), CD68-TAM 2.19 (1.56), IL17+ cells 0.39 (0.39), PD1-TILs 0.19 (0.41). The median follow-up was 47.5 (22.4\u201363.3) months. At statistical analysis, the density of CD8-TILs inversely correlated with lymph node ratio (p\u2009=\u20090.013), number of metastatic lymph nodes (p\u2009=\u20090.019), and was lower in N+\u2009adenocarcinomas compared to N0 (1.07 vs 0.29; p\u2009=\u20090.093), albeit not significantly. Stratifying patients for the N status, the density of CD8-TILs decreased with the increasing of the N stage (p\u2009=\u20090.065) and was lower in patients who experienced recurrence and died for the disease (0.276 vs 0.641; p\u2009=\u20090.044). Notably, also CD68-TAM distribution was different in patients who had recurrence versus patients who did not (1.028 vs 2.276; p\u2009=\u20090.036).
Conclusions
Immune cells showed variable expression in correlation with common prognostic factors, suggesting T cell infiltration may play a protective role towards lymphatic spread of disease and nodal metastatization. Furthermore, T cell density and macrophage infiltration were associated to a lower risk of recurrence and disease related death. A multicentric approach may be indicated to allow analysis of larger cohorts of patients, potentially increasing the power of our observations
GIS integration of DInSAR measurements, geological investigation and historical surveys for the structural monitoring of buildings and infrastructures. An application to the Valco San Paolo urban area of Rome
Structural health monitoring is a crucial issue in areas with different hazard sources, such as Italy. Among non-invasive monitoring techniques, remote sensing provides useful information in supporting the management process and safety evaluations, reducing the impact of disturbances on the functionality of construction systems. The ground displacement time-series based on the analysis of Differential Interferometric Synthetic Aperture Radar (DInSAR) measurements, as well as the information about the geology of the area and the geometry of the construction under monitoring, provides useful data for the built environment's structural assessment. This paper focuses on the structural monitoring and damage assessment of constructions based on the GIS integration of DInSAR measurements, geological investigation, historical surveys and 3D modeling. The methodology is applied to the residential area of Valco San Paolo in the city of Rome (Italy). Once the geological interpretation has confirmed the results of the DInSAR measurements, a quick damage assessment that considers all the possible conditions of the pre-existing damage at the time zero of the monitoring is shown for a damaged manufact in the area. The presented results highlight how the strategy to correlate the DInSAR-monitored ground settlements with the damage scales allows potentially to monitor continuous construction systems
- …