Radiotherapy Response of Cervical Cancer Patients at a Tertiary Referral Hospital in Indonesia

Objective: To investigate the response of radiotherapy and related clinicopathologic characterictics on cervical cancer patients. Methods: This was a retrospective study. Subjects were patients diagnosed with cervical cancer stage IIA-IIIB who had undergone radiation therapy based on standard protocol in our hospital, during the period of January 2014 to December 2015. The clinical factors of those patients, such as age, Body Mass Index, blood pressure, hemoglobin level, blood leucocyte count, serum albumin, largest tumor diameter, the International Federation of Gynecology and Obstetrics (FIGO) staging, as well as pathologic characteristic, i.e histopathology and grading were recorded. During radiation protocol until 3 months post radiation, we also noted any side effects of gastrointestinal tract, genitourinary tract, and hematologic. Evaluation of radiotherapy response was based on Response Evaluation Criteria in Solid Tumors (RECIST).  Results: A total of 123 subjects were enrolled in this study. 84 cases or 68.29% was complete response, 30 cases or 24.39% was partial response, 6 cases or 4.88% was stabile response, and 3 cases or 2.44% was progressive. Based on gastrointestinal side effect, there was no side effect or grade 0 on 99 cases (80.49%), grade 1 on 20 cases (16.26%), grade 2 on 4 cases (3.25%), grade 3 on 0 case (0%). Based on side effect of genitourinary, there was no side effect or grade 0 on 105 cases (85.37%), grade 1 on 17 cases (13.82%), grade 2 on 1 case (0.81%), grade 3 on 0 case (0%). Based on hematologic side effects, there was no side effect on 108 cases (87.80%), grade 1 on 15 cases (12.20%), grade 2 on 0 case (0%), grade 3 on 0 case (0%). Largest tumor diameter was statistically significant, with p=0.036 (RR 2.64 (1.07-6.56)). Conclusion: The majority of definitive-curative radiotherapy response on cervical cancer stage IIA-IIIB was complete (68.29%). Acute side effects involving the gastrointestinal, genitourinary, and hematologic system were commonly can be tolerable during and 3 months post radiation therapy. Clinicopathologic characteristics significantly associated with the complete response of radiotherapy was the largest tumor diameter. Keywords: largest tumor diameter, radiation response, radiation side effec

Radiotherapy Response of Cervical Cancer Patients at a Tertiary Referral Hospital in Indonesia: Respon Terapi Radiasi Pasien Kanker Serviks pada suatu Rumah Sakit Rujukan Tersier

Objective: To investigate the response of radiotherapy and related clinicopathologic characterictics on cervical cancer patients. Methods: This was a retrospective study. Subjects were patients diagnosed with cervical cancer stage IIA-IIIB who had undergone radiation therapy based on standard protocol in our hospital, during the period of January 2014 to December 2015. The clinical factors ofthose patients, such as age, Body Mass Index, blood pressure, hemoglobin level, blood leucocyte count, serum albumin, largest tumor diameter, the International Federation of Gynecology and Obstetrics (FIGO) staging, as well as pathologic characteristic, i.e histopathology and grading were recorded. During radiation protocol until 3months post radiation, we also noted any side effects of gastrointestinal tract, genitourinary tract, and hematologic. Evaluation of radiotherapy response was based on Response Evaluation Criteria in Solid Tumors (RECIST).  Results: A total of 123 subjects were enrolled in this study. 84 cases or 68.29% was complete response, 30 cases or 24.39% was partial response, 6 cases or 4.88% was stabile response, and 3 cases or 2.44% was progressive. Based on gastrointestinal side effect, there was no side effect or grade 0 on 99 cases (80.49%), grade 1 on 20 cases (16.26%), grade 2 on 4 cases (3.25%), grade 3 on 0 case (0%). Based on side effect of genitourinary, there was no side effect or grade 0 on 105 cases (85.37%), grade 1 on 17 cases (13.82%), grade 2 on 1 case (0.81%), grade 3 on 0 case (0%). Based on hematologic side effects, there was no side effecton 108 cases (87.80%), grade 1 on 15 cases (12.20%), grade 2 on 0 case (0%), grade 3 on 0 case (0%). Largest tumor diameter was statistically significant, with p=0.036 (RR 2.64 (1.07-6.56)). Conclusion: The majority of definitive-curative radiotherapy response on cervical cancer stage IIA-IIIB was complete (68.29%). Acute side effects involving the gastrointestinal, genitourinary, and hematologic system were commonly can be tolerable during and 3 months post radiation therapy. Clinicopathologic characteristics significantly associated with the complete response of radiotherapy was the largest tumor diameter. Keywords: largest tumor diameter, radiation response, radiationside effec

Model Peramalan Jumlah Penjualan Sparepart dengan Algoritma Forecasting Time Series: Studi Kasus di PT. XYZ

Peramalan penjualan merupakan hal yang sangat penting bagi perusahaan dalam menentukan seberapa banyak barang (sparepart) yang harus disiapkan untuk penjualan di masa yang akan datang. Dengan peramalan yang tepat dapat mengoptimalkan penjualan meskipun dengan modal dan tempat penyimpanan yang terbatas. Peramalan penjualan dapat dilakukan dengan berbagai macam teknik dan metode. Metode yang digunakan dalam penelitian ini adalah metode Forecasting Time Series. Metode ini sering digunakan dalam memprediksi penjualan karena output yang dihasilkan mempunyai tingkat akurasi yang tinggi. Hasil penelitian ini menunjukkan algoritma Forecasting Time Series dapat digunakan untuk meramalkan jumlah penjualan sparepart dengan cukup baik, hal ini dapat dilihat dari nilai error (MAE) yang kecil yaitu antara 12,20 sampai dengan 18,31. Algoritma Forecasting terbaik dalam penelitian ini yaitu algoritma Wieghted Moving Average (WMA). Hasil pengujian metode WMA dengan data training yaitu MAE 9,62, MSE 122,67, RMSE 2,97 dan MAPE 18,37% sedangkan dengan menggunakan data testing yaitu MAE 11,53, MSE 174,13, RMSE 3,26 dan MAPE 19,56%

Treatment Response of PlatinumBased Chemoradiation on Locally Advanced Cervical Cancer

Objective: To evaluate the efficacy (treatment response), toxicity, and overall survival of concomitant chemoradiation (CRT) with three-weekly cisplatin-ifosfamide compared to CRT with weekly cisplatin in advanced stage cervical cancers (stage IIB-IIIB). Method: This is a historical cohort between 32 patients receiving CRT with three-weekly cisplatin and ifosfamide and 29 patients receiving weekly cisplatin in Gynecologic Oncology division outpatient clinic and ward, Dr. Cipto Mangunkusumo Hospital. Results: There was no significant difference in treatment response, overall and disease-free survival. There was more gastrointestinal toxicity in the cisplatin-ifosfamide arm compared to the other arm (p=0.014), but other toxicity effects were not different. Conclusion: Platinum based-chemoradiation has the same efficacy in terms of treatment response for locally advanced cervical cancer. [Indones J Obstet Gynecol 2015; 3-4: 212-221] Keywords: cisplatin, concomitant chemoradiation, ifosfamide, locally advance stage cervical cance

Feeding behaviour of termites (Insecta: Isoptera) on tropical timbers and treated materials

The feeding behaviour of five species of dry-wood termite (Kalotermitidae) and six species of subterranean termite (fthinoter&lt;nitidae and Termitidae) was studied experimentally. Small samples of 28 tropical timbers were tested with the dry-coed termite Cryptotermes cynocephalus and the subterranean termites Coptotermes curvignathus and Reticulitermes lucifugus. A resistance classification of the 28 tropical timbers to the three species of termites was derived on the basis of cluster analysis. The effects of naturally-occurring chemicals and termite soldier defence secretions on termite feeding behaviour were also included in these studies.The results revealed that four among 28 species of wood studied were completely resistant and repellent to the three species of termite: The four species of wood are Dalbergia latifolia, T,eideroxylon zwageri Intsia bijuga and Tpctona grandi.s. The presence of secondary substances, which apparently cause rejection of the woods, is believed to be the main reason of their resistance to termites. Extracts of selected resistant woods and synthetic samples of known secondary substances were shown to be repellent to the termites Agathis alba, Dipterocarpus species and Mangifera species are classified as most preferred wood species to termites. The feeding activity of termites was also associated with side hardness of the timbers, but not with ash content, basic density or lignin content. The wood extracts have stronger repellent effect than the solid wood. Extracts of resistant wood species were toxic to the dry-wood termite C. cynocephalus and repellent to the subterranean termites. Naturally-occurring chemicals inhibited the feeding behaviour of termites. The monoterpenes were repellent to termites although they were non-toxic at the concentrations used. Qiinones and anthraquinones were both repellent and toxic. The chemicals were more toxic and repellent to termites when they were used on filter pads than when they were presented on wood chips. Soldier extracts (major and minor) of Schedorhinotermes malaccensis (Rhinotermitidae) may be of value in protecting timbers and treated materials against termite attack, although relatively high concentrations may be required. Soldier extracts of this species of termite were toxic and repellent to the dry-wood termite C. cynocephalus. The extracts were also repellent to C. dudleyi and to the subterranean termite R. lucifugus. Ketones similar to those putorius and S. lamanianus were found inextracts of major and minor soldiers of S. malaccensis.</p

ORGANISME PERUSAK KAYU PADA RUMAH RAKYAT DIYOGYAKARTA

Many  householders in  Yogyakarta  find  that  tney  need to know  something about  wood  destroying  organisms.   This may  be because  they  suspect  a problem  exists  in their house,  or  because  they plan  to buy  or build new house,  and wish  to avoid  serious  problems   during  use. However,   not  all damage  observed  should  cause concern,   as some  insects  attact only green  timber  and  their activity   cease  when  the  timber  dries-up. On the  other  hand.  some  insects  cause extensive  and con- tinuing  damage  and  can  be difficult  or expensive   to control

Organisme Perusak Kayu pada Rumah Rakyat Diyogyakarta

Many householders in Yogyakarta find that tney need to know something about wood destroying organisms. This may be because they suspect a problem exists in their house, or because they plan to buy or build new house, and wish to avoid serious problems during use. However, not all damage observed should cause concern, as some insects attact only green timber and their activity cease when the timber dries-up. On the other hand. some insects cause extensive and con- tinuing damage and can be difficult or expensive to control

Survival rate and prognostic factors in advanced cervical cancer patients accompanied by renal impairment

<p>The objective of this study was to obtain information on the  survival rate  of advanced cervical cancer patients with  renal impairment (ACCRI) and its prognostic factors. In addition, it is hoped that by this method the scoring system for predicting the death of  ACCRI patients hopetully  could be obtained.  Design of the study used was retrospective cohort study. Data collected  were retrieved from  medical  records of  ACCRI patients from 1 January 1998 to  31 December 2003 at Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, with a total sample of 70 cases. The results of the study showed that mean survival of  all ACCRI patients  was 8.2 months,  mean survival at sixth month was 39%, and mean survival  at one year was 3.2%. Median survival was  5.3 months. Prognostic factors affecting the survival of ACCRI patients included  histopathological type (adenosquamous cell and cell differentiation), cortical thickness of the kidney less than 1 cm, and nephrostomy. <em><strong>(Med J Indones 2005; 14: 173-8)</strong></em></p><p><strong>Keywords: </strong><em>Advance cervical cancer, renal impairment, nephrostomy, survival prognostic factor, scoring system</em></p