5 research outputs found
The effect of different divalent cations on the kinetics and fidelity of <em>Bacillus stearothermophilus</em> DNA polymerase
- Author
- Bock CW Katz AK, Markham GD, et al.
- Cowna JA
- Drake JW
- Hays H Berdis AJ
- Johnson SJ Beese LS
- Johnson SJ Taylor JS, Beese LS
- Miyaki M Murata I, Osabe M, et al.
- Nakamura T Zhao Y, Yamagata Y, et al.
- Pelletier H Sawaya MR, Wolfle W, et al.
- Sirover MA Loeb LA
- Steitz TA Steitz JA
- Vaisman A Ling H, Woodgate R, et al.
- Vashishtha AK Konigsberg WH
- Vashishtha AK Wang J, Konigsberg WH
- Villani G Tanguy LGN, Wasungu L, et al.
- Wang W Hellinga HW, Beese LS
- Xia S Wang M, Blaha G, et al.
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2018
- Field of study
Effect of Different Divalent Cations on the Kinetics and Fidelity of DNA Polymerases
- Author
- Bakhtina M Lee S, Wang Y, et al.
- Beard WA Wilson SH
- Beard WA Wilson SH
- Bebenek K Pedersen LC, Kunkel TA
- Beckman RA Mildvan AS, Loeb LA
- Bock CW Katz AK, Markham GD, et al.
- Doetsch PW Chan GL, Haseltine WA
- Drake JW
- Dube DK Loeb LA
- Echols H Goodman MF
- Ellefson JW Gollihar J, Shroff R, et al.
- Filee J Forterre P, Sen-Lin T, et al.
- Freudenthal BD Beard WA, Shock DD, et al.
- Frey MW Sowers LC, Millar DP, et al.
- Gao Y Yang W
- Hariharan C Bloom LB, Helquist SA, et al.
- Harris VH Smith CL, Cummins WJ, et al.
- Hays H Berdis AJ
- Irimia A Loukachevitch LV, Eoff RL, et al.
- Irimia A Zang H, Loukachevitch LV, et al.
- Jin YH Clark AB, Slebos RJC, et al.
- Johnson KA
- Johnson SJ Beese LS
- Johnson SJ Taylor JS, Beese LS
- Joyce CM Benkovic SJ
- Kuchta RD Mizrahi V, Benkovic PA, et al.
- Kunkel T Bebenek K
- Kunkel TA Bebenek K
- Lee HR Wang M, Konigsberg W
- Miyaki M Murata I, Osabe M, et al.
- Nakamura T Zhao Y, Yamagata Y, et al.
- Pelletier H Sawaya MR, Wolfle W, et al.
- Schmitt MW Kennedy SR, Salk JJ, et al.
- Sirover MA Loeb LA
- Sirover MA Loeb LA
- Sirover MA Loeb LA
- Snow ET Xu LS, Kinney PL
- Sobol RW Wilson SH
- Tabor S Richardson CC
- Topal MD Fresco JR
- Vaisman A Ling H, Woodgate R, et al.
- Vashishtha AK Konigsberg WH
- Vashishtha AK Konigsberg WH
- Vashishtha AK Kuchta RD
- Vashishtha AK Kuchta RD
- Vashishtha AK Wang J, Konigsberg WH
- Villani G Tanquy Le Gac N, Wasungu L, et al.
- Wang W Hellinga HW, Beese LS
- Xia S Konigsberg WH
- Xia S Vashishtha A, Bulkley D, et al.
- Xia S Wang J, Konigsberg WH
- Xia S Wang M, Blaha G, et al.
- Yang L Arora K, Beard WA, et al.
- Yasukawa K Iida K, Okano H, et al.
- Zhang H Cao W, Zakharova E, et al.
- Zhang Y Baranovskiy AG, Tahirov ET
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2018
- Field of study
JCS/JHRS 2019 guideline on non‐pharmacotherapy of cardiac arrhythmias
- Author
- Abadir S
- Abdelrahman M
- Abraham WT
- Abraham WT
- Abreu Filho CA
- Acosta J
- Ad N
- Ad N
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- Ad N
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- Afari ME
- Aiba T
- Ailawadi G
- Ainsworth CD
- Aiyagari R
- Aizawa Y
- Aizawa Y
- Al Halabi S
- Alexander ME
- Allessie MA
- Almendral JM
- Alonso C
- Al‐Khatib SM
- Al‐Khatib SM
- American Board of Internal Medicine
- American Society of Anesthesiologists Task Force on Sedation and Analgesia by Non‐Anesthesiologists
- Ammirati F
- Amsterdam EA
- An HS
- Anand RG
- Anderson RH
- Anderson RH
- Andrade JG
- Andreu D
- Andreu D
- Anter E
- Antiarrhythmics versus Implantable Defibrillators (AVID) Investigators
- Antonelli D
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- Aonuma K
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- Aranda JM
- Arenal A
- Arenal A
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- Baldinger SH
- Baman TS
- Bando K
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- Barakat AF
- Bardy GH
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- Barnett SD
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- Bar‐Cohen Y
- Basso C
- Bastani H
- Beder SD
- Behr ER
- Benson DW
- Berruezo A
- Berruezo A
- Bertels RA
- Beshai JF
- Betensky BP
- Bhargava M
- Bhavani SS
- Bhonsale A
- Bigger JT
- Bisleri G
- Blackshear JL
- Blanck Z
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- Bollmann A
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- Borggrefe M
- Boriani G
- Bos JM
- Bourier F
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- Bromberg BI
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- Chang HY
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- Cheezum MK
- Chen CA
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- Chen L
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- Chen YJ
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- Cherniavsky A
- Chetaille P
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- Handler M
- Hanninen M
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- Healthcare Engineering Association of Japan
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- Publication venue
- 'Wiley'
- Publication date
- Field of study
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
- Abe S
- Abel L
- Abel L
- Abernathy C
- Abraham R
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- Moore LSP
- Moore SC
- Mooser V
- Morales-Sosa PA
- Morano EMH
- Moreno V
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- Moreno-Estrada A
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- Muñóz-Hernández LL
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- Ortega-Paino E
- Ortiz AB
- Osbourne W
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- Yasui Y
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- Yatomi M
- Ye C
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- Yeung RSM
- Yi X
- Yonekawa A
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- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
- Zamikula J
- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
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- Zhou W
- Zhu W
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- Zongo O
- Zorloni C
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- Zárate RN
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- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
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- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
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- Arana E
- Arbane G
- Archer K
- Arciero E
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- Armstrong JA
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- Artuso R
- Arumugam P
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- Ascolillo S
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- Ashley E
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- Asselta R
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- Blakemore H
- Blanco-Grau A
- Blasi F
- Blay N
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- Blow S
- Blunt M
- Boada M
- Board S
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- Bocciolone M
- Bochud M
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- Boer C
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- Bogaert D
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- Botta G
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- Bretherick AD
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- Brusco A
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- Buckley C
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- Bugiani M
- Bujanda L
- Bulik CM
- Bulle E
- Bullock K
- Bulteel N
- Bunni L
- Burda D
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- Burn I
- Burnett C
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- Burtenshaw A
- Burton M
- Busani S
- Busson A
- Bussotti M
- Bustamante C
- Butcher D
- Buti M
- Butler A
- Butler S
- Butler-Laporte G
- Butler-Laporte G
- Butler-Laporte G
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- Butte MJ
- Butterworth AS
- Butterworth-Cowin N
- Button H
- Buxbaum JD
- Buxbaum JD
- Buxbaum JD
- Byun J
- Caba Llero-Garralda A
- Cabrelli L
- Caceres M
- Cadilla CL
- Cagova L
- Caldarelli GP
- Calderon EJ
- Callaghan M
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- Camsooksai J
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- Cardamone G
- Carella M
- Carey DJ
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- Carrabba M
- Carracedo AD
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- Cawthron K
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- Cea C
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- Chadbourn I
- Chadwick D
- Chadwick D
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- Chang Y
- Chapman S
- Charles B
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- Charney AW
- Charnock R
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- Chaudhary K
- Chavan S
- Chechi K
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- Cheng N
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- Chernitsov A
- Cherubini A
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- Cheyne C
- Chiba S
- Chihara Y
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- Childs D
- Chittoor G
- Chiu A
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- Chung R
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- Cirulli ET
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- Clark V
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- Clement I
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- Clerc O
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- Cordioli M
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- Coton Z
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- de Bree G
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- de Gordoa LO-R
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- De Grandi A
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- de Jong MD
- De la Horra C
- De Neef M
- de Pablo R
- de Rojas I
- de Salazar A
- de Silva T
- De Vivo O
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- de Vries H
- Deacon B
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- Death Y
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- di Bartolomeo C
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- Durrant G
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- Dutta AK
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- Wilkinson A
- Wilkinson B
- Willer CJ
- Williams A
- Williams A
- Williams A
- Williams D
- Williams F
- Williams G
- Williams H
- Williams K
- Williams M
- Williams M
- Williams P
- Williams S
- Williams T
- Willis H
- Wills M
- Willson J
- Wilson A
- Wilson DJ
- Wilson J
- Wilson JF
- Wilson L
- Winchester S
- Winnard S
- Winter-Goodwin B
- Wiselka M
- Wittig M
- Witzke O
- Wolf-Roberts R
- Wolford B
- Wolford B
- Wolterman RA
- Wolverson A
- Wong J
- Wood D
- Wood H-L
- Wood S
- Wood T
- Woodford C
- Woodruff M
- Woods L
- Woodyatt W
- Woolley AE
- Wooton DG
- Working UCLAHATLASDM
- Workman A
- Worner R
- Worsley L
- Wouters D
- Wozniak H
- Wray G
- Wren L
- Wright D
- Wright J
- Wright J
- Wright M
- Wrobel N
- Wrobel N
- Wu Y
- Wulandari R
- Wyllie DH
- Wynter I
- Xavier K
- Xue X
- Yadav A
- Yagi K
- Yamada M
- Yamada Y
- Yamagata K
- Yamasaki M
- Yang G
- Yang J
- Yang Z
- Yaspan B
- Yasui Y
- Yates B
- Yates B
- Yatomi M
- Ye C
- Yengo L
- Yermakovich D
- Yi X
- Yonekawa A
- Yoon H
- Yoon KJ
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Youlton N
- Younes SE
- Young P
- Yun N
- Zak A
- Zaki A
- Zambon M
- Zamikula J
- Zanella A
- Zanella I
- Zanelli G
- Zara F
- Zara F
- Zarate R
- Zarate R
- Zborowski AC
- Zeberg H
- Zechner M
- Zechner M
- Zguro K
- Zhai R
- Zhang JE
- Zhang M
- Zhao JH
- Zhen J
- Zheng C
- Zheng T
- Zhou W
- Zhou W
- Zhu W
- Zitter L
- Zlatopolsky M
- Zoller H
- Zollner S
- Zongo O
- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease