Synthesis and molecular docking studies of coumarin-imidazole conjugates as potential antimicrobial agents

110-125One-pot multi-component synthesis of tri and tetra-substituted coumarin-imidazole conjugates have been achieved in good to excellent yield under conventional and microwave methods in optimized catalyst condition. Further, they have been evaluated for antimicrobial activity against Gram positive Bacillus flexus and Gram negative Pseudomonas Spp. bacterial strains and two strains of fungi Scopulariopsis spp. and Aspergillus tereus organisms. The results of microbial activity are promising against tested organisms. The molecular docking study has been performed for all the compounds and docking scores are excellent. Synthesized compounds have been characterized by IR, NMR, mass and a few of them by single crystal X-ray analysis

Synthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents

The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a-o via sequential multicomponent reaction using catalytic amount of triethylamine (TEA). These new coumarin scaffolds have been successfully explored for the effective inflammatory as well as microbial infection inhibitors. The antimicrobial activity results of the title compounds have shown potent activity against both gram positive and gram negative bacterial, and fungal stains. Additionally, anti-inflammatory activity of all the compounds has been found to be quite promising in comparison with standard Diclofenac sodium. Furthermore, the in silico docking study has been performed for all the compounds with S. aureus DNA gyrase and cyclooxygenase-2 (PDB ID 4PH9). The computational results are in good agreement with the in vitro antibacterial and anti-inflammatory experimental results.

Synthesis, in vitro biological evaluation and molecular docking study of coumarin-1,4-dihydropyridine derivatives as potent anti-inflammatory agents

418-432The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a-o via sequential multicomponent reaction using catalytic amount of triethylamine (TEA). These new coumarin scaffolds have been successfully explored for the effective inflammatory as well as microbial infection inhibitors. The antimicrobial activity results of the title compounds have shown potent activity against both gram positive and gram negative bacterial, and fungal stains. Additionally, anti-inflammatory activity of all the compounds has been found to be quite promising in comparison with standard Diclofenac sodium. Furthermore, the in silico docking study has been performed for all the compounds with S. aureus DNA gyrase and cyclooxygenase-2 (PDB ID 4PH9). The computational results are in good agreement with the in vitro antibacterial and anti-inflammatory experimental results

A Phyto Pharmacological Comparitive Review on Curcuma Species

Since the dawn of time, medicinal plants have been employed by local populations as a source of healing throughout the healthcare system to demonstrate their efficacy. Some of the results have sparked the development of plant-based medications. The most intricate of interactions would be the investigation of how plants work. This essay examines the function of contemporary pharmacology in relation to a variety of plant derived medicines that has been used for millennia and were know to ancient civilizations. The skill of pharmacists and doctors to engage to the challenges that have arose with the propagation of professional services in the assistance of mans life has increased as a result of wisdom of the development of ideas related to the use of herbal medicines as well as the evolution of awareness. It has been noticed that the plant contained antibacterial, antioxidant, analgesic antifungal, antiasthmatic ,smooth pain reliever, locomotor depressant, anti convulsant and muscle relaxing actions as well as anti inflammatory characteristics. It is now thought of as a useful source of distinctive natural compounds for the creation of medicines against different diseases. According to phytochemical studies, the main chemical components of Curcuma aromatica and Curcuma caesia are terpenoids, flavonoids, phenolic compounds, tannins, inorganic compounds, organic acids and anthocyanin

An efficient and catalyst free methylthiolation of 4-(bromomethyl)-2<i>H</i>-chromen-2-ones with DMSO

<p></p> <p>The first simple, metal free, and efficient protocol has been established for the methylthiolation of structurally diverse 4-bromomethyl-2<i>H</i>-chromen-2-ones using dimethyl sulfoxide (DMSO) as methylthiolation source at higher temperature. The experimental method is highly economical and provides excellent yields of highly pure products which do not require further purification. All novel 4-[(methylthio)methyl]-2<i>H</i>-chromen-2-ones were characterized by ¹H, ¹³C NMR, and single-crystal X-ray analysis.</p

Design, synthesis, characterization, photophysical and pH chemosensor studies of novel 2,4,6-trisubstituted pyridines

<p>For the application in organic electronics as well as pH meters, a series of novel 2,4,6-trisubstituted pyridines have been synthesized by the reaction of substituted aromatic aldehydes and substituted 3-acetylcoumarin with ammonium acetate. The structures of all the new compounds were characterized by IR, NMR, and GC–MS analysis. The important photo physical prerequisites for organoelectronic such as optical absorption and thermal stability were determined for the synthesized molecules. Optical properties were studied by UV–visible absorption and fluorescence spectroscopy. Optical band gaps of the 2,4,6-trisubstituted pyridines were found to be around 3.01–3.06 eV as calculated from their onset absorption edge. The pH-dependent changes in the fluorescence intensity suggest that 2,4,6-trisubstituted pyridines are useful applicants in intracellular pH meters.</p