1,065 research outputs found
The Possible Role of Transplacentally-Acquired Antibodies to Infectious Agents, With Molecular Mimicry to Nervous System Sialic Acid Epitopes, as Causes of Neuromental Disorders: Prevention and Vaccine Implications
Proof of causality of most neuromental disorders (NMD's) is largely unavailable. Lessons from four-decade investigations of the epidemiology, immunology, pathogenesis, prevention and therapy of perinatal infectious agents, which invade directly the nervous system, have led us to propose a new indirect effect hypothesis: maternal transplacentally-acquired antibodies, to agents with epitope molecular mimicry with the developing nervous system, can cross the fetus/infant's blood–nervous system barriers to cause NMD's, clinically manifest years later
SIMPEL: Circuit model for photonic spike processing laser neurons
We propose an equivalent circuit model for photonic spike processing laser
neurons with an embedded saturable absorber---a simulation model for photonic
excitable lasers (SIMPEL). We show that by mapping the laser neuron rate
equations into a circuit model, SPICE analysis can be used as an efficient and
accurate engine for numerical calculations, capable of generalization to a
variety of different laser neuron types found in literature. The development of
this model parallels the Hodgkin--Huxley model of neuron biophysics, a circuit
framework which brought efficiency, modularity, and generalizability to the
study of neural dynamics. We employ the model to study various
signal-processing effects such as excitability with excitatory and inhibitory
pulses, binary all-or-nothing response, and bistable dynamics.Comment: 16 pages, 7 figure
Dynamical laser spike processing
Novel materials and devices in photonics have the potential to revolutionize
optical information processing, beyond conventional binary-logic approaches.
Laser systems offer a rich repertoire of useful dynamical behaviors, including
the excitable dynamics also found in the time-resolved "spiking" of neurons.
Spiking reconciles the expressiveness and efficiency of analog processing with
the robustness and scalability of digital processing. We demonstrate that
graphene-coupled laser systems offer a unified low-level spike optical
processing paradigm that goes well beyond previously studied laser dynamics. We
show that this platform can simultaneously exhibit logic-level restoration,
cascadability and input-output isolation---fundamental challenges in optical
information processing. We also implement low-level spike-processing tasks that
are critical for higher level processing: temporal pattern detection and stable
recurrent memory. We study these properties in the context of a fiber laser
system, but the addition of graphene leads to a number of advantages which stem
from its unique properties, including high absorption and fast carrier
relaxation. These could lead to significant speed and efficiency improvements
in unconventional laser processing devices, and ongoing research on graphene
microfabrication promises compatibility with integrated laser platforms.Comment: 13 pages, 7 figure
Principles of Neuromorphic Photonics
In an age overrun with information, the ability to process reams of data has
become crucial. The demand for data will continue to grow as smart gadgets
multiply and become increasingly integrated into our daily lives.
Next-generation industries in artificial intelligence services and
high-performance computing are so far supported by microelectronic platforms.
These data-intensive enterprises rely on continual improvements in hardware.
Their prospects are running up against a stark reality: conventional
one-size-fits-all solutions offered by digital electronics can no longer
satisfy this need, as Moore's law (exponential hardware scaling),
interconnection density, and the von Neumann architecture reach their limits.
With its superior speed and reconfigurability, analog photonics can provide
some relief to these problems; however, complex applications of analog
photonics have remained largely unexplored due to the absence of a robust
photonic integration industry. Recently, the landscape for
commercially-manufacturable photonic chips has been changing rapidly and now
promises to achieve economies of scale previously enjoyed solely by
microelectronics.
The scientific community has set out to build bridges between the domains of
photonic device physics and neural networks, giving rise to the field of
\emph{neuromorphic photonics}. This article reviews the recent progress in
integrated neuromorphic photonics. We provide an overview of neuromorphic
computing, discuss the associated technology (microelectronic and photonic)
platforms and compare their metric performance. We discuss photonic neural
network approaches and challenges for integrated neuromorphic photonic
processors while providing an in-depth description of photonic neurons and a
candidate interconnection architecture. We conclude with a future outlook of
neuro-inspired photonic processing.Comment: 28 pages, 19 figure
The Ontology of Intentional Agency in Light of Neurobiological Determinism: Philosophy Meets Folk Psychology
The moot point of the Western philosophical rhetoric about free will
consists in examining whether the claim of authorship to intentional, deliberative
actions fits into or is undermined by a one-way causal framework of determinism.
Philosophers who think that reconciliation between the two is possible are known as
metaphysical compatibilists. However, there are philosophers populating the other
end of the spectrum, known as the metaphysical libertarians, who maintain that claim
to intentional agency cannot be sustained unless it is assumed that indeterministic
causal processes pervade the action-implementation apparatus employed by the agent.
The metaphysical libertarians differ among themselves on the question of whether the
indeterministic causal relation exists between the series of intentional states and
processes, both conscious and unconscious, and the action, making claim for what has
come to be known as the event-causal view, or between the agent and the action,
arguing that a sort of agent causation is at work. In this paper, I have tried to propose
that certain features of both event-causal and agent-causal libertarian views need to be
combined in order to provide a more defendable compatibilist account accommodating
deliberative actions with deterministic causation. The ‘‘agent-executed-eventcausal
libertarianism’’, the account of agency I have tried to develop here, integrates
certain plausible features of the two competing accounts of libertarianism turning
them into a consistent whole. I hope to show in the process that the integration of these
two variants of libertarianism does not challenge what some accounts of metaphysical
compatibilism propose—that there exists a broader deterministic relation between the
web of mental and extra-mental components constituting the agent’s dispositional
system—the agent’s beliefs, desires, short-term and long-term goals based on them,
the acquired social, cultural and religious beliefs, the general and immediate and
situational environment in which the agent is placed, etc. on the one hand and the
decisions she makes over her lifetime on the basis of these factors. While in the
‘‘Introduction’’ the philosophically assumed anomaly between deterministic causation
and the intentional act of deciding has been briefly surveyed, the second section is
devoted to the task of bridging the gap between compatibilism and libertarianism. The
next section of the paper turns to an analysis of folk-psychological concepts and
intuitions about the effects of neurochemical processes and prior mental events on the
freedom of making choices. How philosophical insights can be beneficially informed
by taking into consideration folk-psychological intuitions has also been discussed,
thus setting up the background for such analysis. It has been suggested in the end that
support for the proposed theory of intentional agency can be found in the folk-psychological intuitions, when they are taken in the right perspective
Photonic spike processing: ultrafast laser neurons and an integrated photonic network
The marriage of two vibrant fields---photonics and neuromorphic
processing---is fundamentally enabled by the strong analogies within the
underlying physics between the dynamics of biological neurons and lasers, both
of which can be understood within the framework of nonlinear dynamical systems
theory. Whereas neuromorphic engineering exploits the biophysics of neuronal
computation algorithms to provide a wide range of computing and signal
processing applications, photonics offer an alternative approach to
neuromorphic systems by exploiting the high speed, high bandwidth, and low
crosstalk available to photonic interconnects which potentially grants the
capacity for complex, ultrafast categorization and decision-making. Here we
highlight some recent progress on this exciting field.Comment: 11 pages, 8 figure
Herpes Simplex Virus Type 2 Antibodies: High Prevalence in Monogamous Women in Costa Rica
We studied the prevalence of antibody to Herpes simplex virus types I and 2 (HSV-I and HSV-2) in 766 randomly selected Costa Rican women 25-59 years of age in a national household survey in 1984-1985. Overall, 97.1% were seropositive for HSV-l and 39.4% for HSV -2. Only 1.1% of HSV -2 seropositive women gave a history of symptomatic genital herpes. HSV-2 virus antibody increased with age and with the number of lifetime sexual partners. HSV -2 seroprevalence among women who reported only 1 lifetime sexual partner was almost twice as high as the prevalence among women who denied sexual experience (30.5% vs. 17.7%) and reached 79.2% among women with \u3c 4 partners. HSV-2 seroprevalence was lower among women whose partners used condoms: 28.9% for those who had used condoms for at least 2 years vs. 44.3% for those who never used condoms
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