New Marketing Initiatives for Binghamton University\u27s Center for Civic Engagement

Students are vital to fulfill the Center for Civic Engagement\u27s mission to strengthen relationships between Binghamton University and the community. As a new office, engaging and fostering support amongst students and instituting effective means of reaching them is an essential component for establishing a viable center. At the onset of its growing year, CCE;s marketing strategies were ill-equipped to reach a student demographic that is continually evolving and increasingly reliant on the internet and new technologies for its information needs. The ability to understand and effectively adapt to the changing expectations and preferences of students is a vital component to CCE\u27s efforts to appeal to a broader audience

Reaching Real-Time Moving Targets: The Use of Digital Communications to Inform and Mobilize College Students

College professionals and faculty continually look for effective ways to inform and mobilize their students. In pursuit of this goal, the newly-established Center for Civic Engagement (CCE) embarked on a fact-finding process to determine the effectiveness of current digital communication methods, identify challenges, and ascertain student preferences for information dissemination. After reviewing appropriate literature, new social media strategies were developed and launched, resulting in CCE’s award-winning marketing and social networking initiatives. This article provides insight into the particular mediums students prefer, development and application of strategies, and their level of effectiveness in engaging young adults

Reaching Real-Time Moving Targets: The Use of Digital Communications to Inform and Mobilize College Students

College professionals and faculty continually look for effective ways to inform and mobilize their students. In pursuit of this goal, the newly-established Center for Civic Engagement (CCE) embarked on a fact-finding process to determine the effectiveness of current digital communication methods, identify challenges, and ascertain student preferences for information dissemination. After reviewing appropriate literature, new social media strategies were developed and launched, resulting in CCEâs award-winning marketing and social networking initiatives. This article provides insight into the particular mediums students prefer, development and application of strategies, and their level of effectiveness in engaging young adults

Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis

The retinoblastoma tumor suppressor (pRB) inhibits tumorigenesis by restraining cell cycle progression via repression of the E2F transcription factor family and by promoting cell differentiation via activation of lineage-specific transcription factors. In contrast, the closely related pRB homologues, p107 and p130, are known to inhibit cell cycle progression by repressing the E2F transcription factor family, but are not known to have roles in promoting cell differentiation. Interestingly, the Rb promoter contains a critical cassette of binding sites (Sp1/Ets, ATF and E2F) that is conserved between mice and humans. Previously, our lab developed a wild type Rb promoter-LacZ transgenic reporter line (T157) that displayed dynamic and neuronal-specific expression (Agromayor et al., 2006). We generated mutant Rb promoter-LacZ transgenic lines and demonstrated that the conserved cassette controls Rb expression, positively through the Sp1/Ets site and negatively through the E2F site. Repression of the Rb promoter through this critical E2F site means that the E2F family lies both upstream and downstream of Rb, and suggests that Rb family members regulate the Rb promoter during neuronal development. To identify which Rb family member represses the Rb promoter during corticogenesis, we generated RbP-LacZ lines in genetic backgrounds deficient in various Rb family members and looked for deregulation of RbP-LacZ activity within the embryo (Aim 1). Surprisingly, RbP-LacZ activity responds in opposing ways with either loss of Rb or dual loss of p107 and p130, demonstrating that regulation of the Rb promoter by Rb family members during corticogenesis is complex. To determine whether direct or indirect mechanisms are responsible for the opposing changes in RbP-LacZ expression with loss of Rb family members in the developing cortex, we evaluated occupancy at the Rb promoter (ChIP analysis), proliferation, cell death (BrdU incorporation and TUNEL analysis) and changes in gene expression (RT-PCR) in wild type vs. mutant cortices from embryos lacking various Rb family members (Aim 2). Interestingly, we found evidence for both direct and indirect action of Rb family member inactivation on the Rb promoter. To determine if the opposing changes in RbP-LacZ activity with either loss of Rb or dual loss of p107 and p130 occurs in a cell autonomous or a non-cell autonomous manner, we optimized and analyzed primary cortical neuron cultures from wild type and mutant embryos to quantitate RbP-LacZ activity on a cell-by-cell basis (Aim 3). We compared changes in the frequency and intensity of RbP-LacZ activity, the distribution of neuronal subpopulations, identified the cells expressing RbP-LacZ activity and evaluated differences in these populations with loss of various Rb family members. Through these studies, we have discovered a complex relationship exists between Rb family members and Pax6 progenitors during corticogenesis, underscoring the intricate nature of the network connecting the Rb and E2f families in vivo

Reconstructing Social Relationships in a Post-Lockdown Suburban Area of Southern Italy Using Pastoral Counselling

UIDB/00472/2020 UIDP/00472/2020The growing interest in spirituality has enabled numerous avenues of pastoral counselling support, which can be a useful resource for improving quality of life in the context of significant social deprivation. The aim of this research was to investigate the role of the spiritual dimension of pastoral support interventions created to help the inhabitants of a strongly deprived territory in Southern Italy during the COVID-19 pandemic. Eight people between the ages of 28 and 67 took part in the study. A qualitative research design was applied via online interviews with the participants, who were operators of a pastoral counselling service located on the outskirts of a suburban town. The main emergent themes were the importance of religiosity and spirituality in the lives of the participants, the role that these two aspects play in the lives of those who carry out activities devoted to helping others, and the ways in which these dimensions are used within support programmes responding to the needs of an area characterized by socioeconomic and psychosocial problems. The interviews revealed how pastoral counselling can be useful in situations of stress in highly deprived areas.publishersversionepub_ahead_of_prin

Implementation of a Pressure Ulcer Prevention Protocol in the Perioperative Setting

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Heterogeneous response to target therapy in metastatic papillary renal cell carcinoma evaluated by morphologic and metabolic multimodality imaging

Papillary renal cell carcinoma (PRCC) accounts for about 15% to 20% of renal cell carcinoma and is histologically distinguished in type I and type II. The last one is associated with poorer prognosis. Treatment options for PRCC patients are surgery, immunotherapy, revolutionized by Nivolumab, and other target-therapy with an improvement in overall survival. Heterogenous response and a pseudo-progression may be observed in the initial phase of biological treatment that could induce premature discontinuation. Patient concerns: We present the case of a 44-year-old woman with left cervical palpable mass increased in size and without concomitant disease or previous surgery. Diagnosis: Neck ultrasonography, contrast-enhanced Computed Tomography, and 18F-FDG PET/CT were performed with the detection of lymph nodes involvement and a left renal lesion. Interventions: The patients underwent left radical nephrectomy and homolateral cervical and para-aortic lymphadenectomy, with histological diagnosis of PRCC, type II. After disease relapse, the inter-aortocaval lymph node was laparoscopically removed. Following the detection of further disease relapse in several lymph nodes and the lung, several lines of target-therapy were started; then disease progression and worsening of clinical and hematological status led us to start Nivolumab as last-line therapy. Outcomes: A heterogeneous response to therapies was documented with morphological and nuclear medicine imaging, however the concomitant deterioration of performance status and liver function led to discontinuation of Nivolumab; then the patient died, 30 months after diagnosis. Lessons: Here we describe the clinical case and radiological and nuclear medicine imaging investigations performed by our patient, highlighting that 18F-FDG PET/CT shows greater adequacy in assessing the response to therapy, avoiding premature drug discontinuation, and ensuring better management of a patient with advanced PRCC

Combating Fear of Missing Out (FoMO) on Social Media: The FoMO-R Method.

Background: The fear of missing out (FoMO) on social media refers to the apprehension that online content and interactions from others are unseen and reacted to in a timely fashion. FoMO can become problematic, leading to anxiety, interrupted sleep, lack of concentration and dependence on social media to generate gratification. The literature has mainly focused on understanding the FoMO experience, factors contributing to it and its consequences. Method: In this paper, we build on previous research and develop a FoMO Reduction (FoMO-R) approach that embraces technical elements such as autoreply, filtering, status, education on how FoMO occurs and skills on how to deal with it; e.g., self-talk and checklists. We evaluate the method through focus groups and a diary study involving 30 participants who self-declared to experience FoMO regularly. Results: The results show that the method was accepted by the participants and helped them to manage their FoMO. They also show that a set of extra functionalities in social media design is needed so that users can manage FoMO more effectively. Conclusion: FoMO can be reduced through socio-technical approaches, joining both social and technical skills, and literacy on how social media are designed and how social interactions should happen on them

Parp inhibitors and epithelial ovarian cancer: Molecular mechanisms, clinical development and future prospective (Review)

Epithelial ovarian cancer (EOC) has a poor prog- nosis. Since the introduction of paclitaxel as antineoplastic agent >20 years ago, only a few phase III randomized trials have shown challenging data regarding different therapeutic options for facing its aggressive clinical course and granting active therapies to patients. Different studies have shown the utility of poly(ADP-ribose) polymerase (PARP) inhibitors in women with EOC with or without BRCA mutations, both germ- line and somatic. Three PARP inhibitors, olaparib, rucaparib and niraparib, have been recently approved by the Food and Drug Administration for clinical use in EOC patients, though with different clinical indications and profiles of toxicity, while two other molecules, veliparib and talazoparib, are still under clinical investigation. The aim of the present paper is to evaluate the current status of PARP inhibitors in terms of molecular activity, pharmacodynamic properties and clinical applications