Análise da variação terminológica denominativa em textos jurídicos: o caso do termo petição inicial

This article aims to present the analysis of the concept of pleading in legal texts. It is verified the possibilities of denominative variants for this term. The denominative variation was chosen because this research starts from a word list of variant candidates.  It was investigated what is understood by the concept of pleading (i.e., the text which initiates the legal process). Hence, it was identified, from the list of variant candidates, which of these words are really used to denominate the text in discussion considering the 20 samples of legal texts analyzed. In order to develop this research, it is considered the assumptions of Freixa (2002; 2006; 2014), Cabré (1999) etc. Therefore, besides identifying if denominative terminological variation occurs, it was verified how it happens in the studied texts.  Este artigo tem como objetivo apresentar a análise do conceito de petição em textos jurídicos verificando as possíveis variantes denominativas para o termo. Enveredamos pela análise da variação denominativa por partimos de uma listagem de termos que são candidatos a variantes. Investigamos o que entendemos como o conceito de petição, ou seja, texto que dá início ao processo jurídico. Com isso, visamos identificar, a partir da lista de candidatos a termos, quais desses são utilizados para denominar o texto em questão na amostra de 20 peças jurídicas que analisamos. Para realizarmos nossa análise, pautamo-nos, principalmente, em Freixa (2002; 2006; 2014), Cabré (1999) etc. Tendo isso, além de identificar se há variação denominativa verificamos como ela ocorre nos textos estudados

A unified lead-oriented synthesis of over fifty molecular scaffolds

Controlling the properties of lead molecules is critical in drug discovery, but sourcing large numbers of lead-like compounds for screening collections is a major challenge. A unified synthetic approach is described that enabled the synthesis of 52 diverse lead-like molecular scaffolds from a minimal set of 13 precursors. The divergent approach exploited a suite of robust, functional group-tolerant transformations. Crucially, after derivatisation, these scaffolds would target significant lead-like chemical space, and complement commercially-available compounds

Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea

Hydroxyurea (HU) is the most important advance in the treatment of sickle cell anaemia (SCA) for preventing complications and improving quality of life for patients. However, some aspects of treatment with HU remain unclear, including their effect on and potential toxicity to other blood cells such as neutrophils. This study used the measurement of Lactate Dehydrogenase (LDH) and Methyl ThiazolTetrazolium (MTT) and the comet assay to investigate the cytotoxicity and damage index (DI) of the DNA in the neutrophils of patients with SCA using HU.In the LDH and MTT assays, a cytoprotective effect was observed in the group of patients treated, as well as an absence of toxicity. When compared to patients without the treatment, the SS group (n=20, 13 women and 07 men, aged 18-69 years), and the group of healthy individuals (AA) used as a control group (n=52, 28 women and 24 men, aged 19-60 years), The SSHU group (n=21, 11 women and 10 men, aged 19-63 years) showed a significant reduction (p20 months), demonstrating that despite the cytoprotective effects in terms of cell viability, the use of HU can induce DNA damage in neutrophils