1,557 research outputs found
Type II Quasars from the Sloan Digital Sky Survey: V. Imaging host galaxies with the Hubble Space Telescope
Type II quasars are luminous Active Galactic Nuclei whose centers are
obscured by large amounts of gas and dust. In this paper we present 3-band HST
images of nine type II quasars with redshifts 0.2 < z < 0.4 selected from the
Sloan Digital Sky Survey based on their emission line properties. The intrinsic
luminosities of these AGN are estimated to be -24 > M_B > -26, but optical
obscuration allows their host galaxies to be studied unencumbered by bright
nuclei. Each object has been imaged in three continuum filters (`UV', `blue'
and `yellow') placed between the strong emission lines. The spectacular, high
quality images reveal a wealth of details about the structure of the host
galaxies and their environments. Six of the nine galaxies in the sample are
ellipticals with de Vaucouleurs light profiles, one object has a well-defined
disk component and the remaining two have marginal disks. Stellar populations
of type II quasar hosts are more luminous (by a median of 0.3-0.7 mag,
depending on the wavelength) and bluer (by about 0.4 mag) than are M* galaxies
at the same redshift. When smooth fits to stellar light are subtracted from the
images, we find both positive and negative residuals that become more prominent
toward shorter wavelengths. We argue that the negative residuals are due to
kpc-scale dust obscuration, while most positive residuals are due to the light
from the nucleus scattered off interstellar material in the host galaxy.
Scattered light makes a significant contribution to the broad band continuum
emission and can be the dominant component of the extended emission in the UV
in extreme cases.Comment: 51 pages, including 12 grey scale figures, 4 color figures, 5 tables.
In press in AJ. Version with higher-resolution images available at
http://www.astro.princeton.edu/~nadia/qso2.html. (Minor changes in response
to the referee report
Embryonic Stem Cells Are Redirected to Non-Tumorigenic Epithelial Cell Fate by Interaction with the Mammary Microenvironment
Experiments were conducted to redirect mouse Embryonic Stem (ES) cells from a tumorigenic phenotype to a normal mammary epithelial phenotype in vivo. Mixing LacZ-labeled ES cells with normal mouse mammary epithelial cells at ratios of 1:5 and 1:50 in phosphate buffered saline and immediately inoculating them into epithelium-divested mammary fat pads of immune-compromised mice accomplished this. Our results indicate that tumorigenesis occurs only when normal mammary ductal growth is not achieved in the inoculated fat pads. When normal mammary gland growth occurs, we find ES cells (LacZ+) progeny interspersed with normal mammary cell progeny in the mammary epithelial structures. We demonstrate that these progeny, marked by LacZ expression, differentiate into multiple epithelial subtypes including steroid receptor positive luminal cells and myoepithelial cells indicating that the ES cells are capable of epithelial multipotency in this context but do not form teratomas. In addition, in secondary transplants, ES cell progeny proliferate, contribute apparently normal mammary progeny, maintain their multipotency and do not produce teratomas
Candidate Type II Quasars at 2 < z < 4.3 in the Sloan Digital Sky Survey III
At low redshifts, dust-obscured quasars often have strong yet narrow
permitted lines in the rest-frame optical and ultraviolet, excited by the
central active nucleus, earning the designation Type II quasars. We present a
sample of 145 candidate Type II quasars at redshifts between 2 and 4.3,
encompassing the epoch at which quasar activity peaked in the universe. These
objects, selected from the quasar sample of the Baryon Oscillation
Spectroscopic Survey of the Sloan Digital Sky Survey III, are characterized by
weak continuum in the rest-frame ultraviolet (typical continuum magnitude of i
\approx 22) and strong lines of CIV and Ly \alpha, with Full Width at Half
Maximum less than 2000 kms-1. The continuum magnitudes correspond to an
absolute magnitude of -23 or brighter at redshift 3, too bright to be due
exclusively to the host galaxies of these objects. Roughly one third of the
objects are detected in the shorter-wavelength bands of the WISE survey; the
spectral energy distributions (SEDs) of these objects appear to be intermediate
between classic Type I and Type II quasars seen at lower redshift. Five objects
are detected at rest frame 6\mu m by Spitzer, implying bolometric luminosities
of several times 10^46 erg s-1. We have obtained polarization measurements for
two objects; they are roughly 3% polarized. We suggest that these objects are
luminous quasars, with modest dust extinction (A_V ~ 0.5 mag), whose
ultraviolet continuum also includes a substantial scattering contribution.
Alternatively, the line of sight to the central engines of these objects may be
partially obscured by optically thick material.Comment: 26 pages, 13 figures, 10 tables, 4 machine readable tables. Accepted
for publication in MNRA
Inverse problems in high pressure processes and food engineering
Depto. de Análisis Matemático y Matemática AplicadaInstituto de Matemática Interdisciplinar (IMI)Fac. de Ciencias MatemáticasTRUEpu
The incremental role of trait emotional intelligence on perceived cervical screening barriers
Researchers have become increasingly interested in investigating the role of the psychological aspects related to the perception of cervical screening barriers. This study investigates the influence of trait EI on perceived cervical screening barriers. Furthermore, this study investigates the incremental validity of trait EI beyond the Big Five, as well as emotion regulation in the perceived barrier towards the Pap test as revealed in a sample of 206 Italian women that were undergoing cervical screening. Results have shown that trait EI is negatively related to cervical screening barriers. Furthermore, trait EI can be considered as a strong incremental predictor of a woman's perception of screening over and above the Big Five, emotion regulation, age, sexual intercourse experience and past Pap test. Detailed information on the study findings and future research directions are discussed
Candidate Type II Quasars from the SDSS: III. Spectropolarimetry Reveals Hidden Type I Nuclei
We have conducted spectropolarimetry of 12 type II (obscured) quasar
candidates selected from the spectroscopic database of the Sloan Digital Sky
Survey based on their emission line properties. Polarization was detected in
all objects, with nine being highly polarized (> 3%) and with polarization
reaching as high as 17% in two objects. Broad lines were detected in the
polarized spectra of five objects. These observations prove beyond a reasonable
doubt that the objects in our sample are indeed type II quasars, in that they
harbor luminous UV-excess AGNs in their centers and that the direct view to the
AGN is highly obscured. For three of the objects in this paper, we have
obtained HST images in three bands. The HST observations, combined with the
spectropolarimetry data, imply that scattering off material outside the
obscuration plane is the dominant polarization mechanism. In all three objects
the sizes of scattering regions are a few kpc. For one object, the extent of
the scattering region, coupled with the characteristics of the polarized
spectrum, argue strongly that dust scattering rather than electron scattering
dominates the polarized light. Our observations are well-described by the basic
orientation-based unification model of toroidal obscuration and off-plane
scattering, implying that the model can be extended to include at least some
high-luminosity AGNs.Comment: 31 pages including 4 b/w pictures, 1 color HST image and 2 tables.
Submitted to AJ on Sept 26, accepted for March 2005. Minor modifications to
match the accepted versio
Study of the Effect of Reconstruction Parameters for Myocardial Perfusion Imaging in PET With a Novel Flow Phantom
Myocardial perfusion imaging (MPI) with positron emission tomography (PET) allows quantitative temporal measurements of the radioactive tracer distribution in tissue. The quantification for myocardial blood flow (MBF) is conducted with kinetic modeling of the image-derived time-activity curves (TACs) allowing derivation for MBF in units of mL/min per gram of tissue. The ordered-subset expectation maximization (OSEM) reconstruction algorithm with time-of-flight (TOF) and point spread function (PSF) modeling is now routinely employed in cardiac imaging. However, the varying counting statistics of the MPI measurements conducted with short-lived tracers present a challenge for the PET image reconstruction methods. Thus, the effect of the reconstruction methods on the flow quantification needs to be evaluated in a standardized manner. Recently, a novel PET flow phantom modeling the MBF has been developed for investigation of the standardization of the MBF measurements. In this study, the effect of the reconstruction parameters on the image-derived flow values against a known reference flow of the flow phantom was studied with [O-15]H2O. The effects were studied by comparison of TACs and relative errors of the image-derived flow values with respect to the phantom-derived reference flow value using 5 repeated PET scans with fixed acquisition parameters using a digital Discovery MI PET/CT system. The reconstruction methods applied were OSEM using both TOF and PSF (OSEM-TOF-PSF) with several matrix sizes (128 x 128, 192 x 192, 256 x 256, 384 x 384), Gaussian filter sizes (4, 8 mm) and OSEM without TOF and PSF (OSEM), with TOF (OSEM-TOF) and with PSF (OSEM-PSF) in addition to recently introduced regularized reconstruction method based on Bayesian-penalized maximum likelihood (Q.Clear). Between repeated measurements, the image-derived flow values showed high repeatability with a SD less than 2 mL/min as well as high accuracy with the maximum error of 7% with respect to the reference flow for all reconstructions. Overall, reconstruction settings had only a small impact on the resulting flow values. In conclusion, due to the small differences detected, any of the implemented reconstruction algorithms on the system can be applied in MPI studies for accurate flow quantification
Measurement uncertainty quantification for myocardial perfusion using cardiac positron emission tomography imaging
Perfusion, the flow of blood, and hence oxygen, is essential to the functioning of the heart. Reduced perfusion (or ischemia), is a reliable indicator of the presence of significant obstructive coronary artery disease (CAD), which is one of the biggest causes of death in Europe. Myocardial perfusion imaging is a non-invasive technique used in the diagnosis, management and prognosis of CAD and is a key component in the triage of patients into treatment and non-treatment groups. Cardiac positron emission tomography (PET) is an imaging technique with high sensitivity and specificity to CAD, however perfusion measurements are difficult to calibrate against a common reference standard, and confidence in them is generally not quantified in terms of measurement uncertainty. There are a number of steps involved in measuring perfusion using cardiac PET-from patient preparation to data analysis-each associated with potential sources of uncertainty. The absence of measurement uncertainty quantification can lead to inaccuracies in measurement results, a lack of comparability between devices or scanning facilities, and is likely to be detrimental to a decision-making process. In this paper, we identify some of the sources of measurement uncertainty in the cardiac PET perfusion measurement pipeline. We assess their relative contribution by performing a sensitivity analysis using experimental data of a flow phantom acquired on a PET scanner. The results of this analysis will inform users of how parameter choices in their imaging pipeline affect the output of their measurements, and serves as a starting point to develop an uncertainty quantification method.</p
Partitioning clustering algorithms for protein sequence data sets
<p>Abstract</p> <p>Background</p> <p>Genome-sequencing projects are currently producing an enormous amount of new sequences and cause the rapid increasing of protein sequence databases. The unsupervised classification of these data into functional groups or families, clustering, has become one of the principal research objectives in structural and functional genomics. Computer programs to automatically and accurately classify sequences into families become a necessity. A significant number of methods have addressed the clustering of protein sequences and most of them can be categorized in three major groups: hierarchical, graph-based and partitioning methods. Among the various sequence clustering methods in literature, hierarchical and graph-based approaches have been widely used. Although partitioning clustering techniques are extremely used in other fields, few applications have been found in the field of protein sequence clustering. It is not fully demonstrated if partitioning methods can be applied to protein sequence data and if these methods can be efficient compared to the published clustering methods.</p> <p>Methods</p> <p>We developed four partitioning clustering approaches using Smith-Waterman local-alignment algorithm to determine pair-wise similarities of sequences. Four different sets of protein sequences were used as evaluation data sets for the proposed methods.</p> <p>Results</p> <p>We show that these methods outperform several other published clustering methods in terms of correctly predicting a classifier and especially in terms of the correctness of the provided prediction. The software is available to academic users from the authors upon request.</p
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