Cells of the adult human heart

Abstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies

Cells of the adult human heart

Abstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies

A tempestade global da lei e ordem: sobre punição e neoliberalismo

Este artigo reflete sobre a recepção internacional ao livro Prisões da miséria como reveladora da expansão penal nas sociedades avançadas na década de 2000. Ele revela que a tempestade global da "lei e ordem" inspirada pelos Estados Unidos, que o livro detectou em 1999, continuou a espalhar-se por toda a parte. Na verdade, ela estendeu-se dos países do Primeiro Mundo para os do Segundo Mundo e alterou a política e as práticas de punição em todo o globo de uma forma que ninguém previa e que ninguém teria pensado como possível há cerca de 15 anos. O artigo estende a análise para o papel dos institutos de consultoria (em especial o Manhattan Institute) na difusão das noções de combate ao crime e das panacéias no estilo estadunidense na América Latina como um elemento da circulação internacional dos pacotes de política pró-mercado que alimentam a gerência punitiva da pobreza. O artigo elabora e revê o modelo original do nexo entre neoliberalismo e penalidade punitiva, levando a análise da montagem do Estado na era da insegurança social, desenvolvida no livro Punindo os pobres

A tale of two cognitions: The Evolution of Social Constructivism in International Relations

Abstract Constructivism in International Relations (IR) is popular, but constructivists seem disappointed. Allegedly something has been lost. Such criticisms are misplaced. There was never a uniform Constructivism. Since constructivism is socially constructed, to argue that constructivism has evolved “wrongly” is odd. This paper explains the dissatisfaction with constructivism followed by a second reading of its evolution as a tale of two cognitions. These two cognitions distinguish genera in the constructivist “family”. A criticism against one genus based on the cognition of the other is unfair. A focus on cognitions and the use of genera helps in perceiving constructivism’s future evolution