Testing Taylor’s Law in Urban Population Dynamics Worldwide with Simultaneous Equation Models

Knowledge of long-term population trends is still incomplete at the global scale. In this perspective, human and animal ecology has intensively studied the relationship between the Mean (M) size and the Variance (V) of specific attributes of subpopulations within a given regional system. One of the best-known relationships between these two attributes suitable to describe long-term population trends is governed by Taylor’s law (TL). The present article contributes to the recent literature on population trends worldwide by testing the long-term relationship (1950–2015) between the overall variance and mean in the total population of 1857 metropolitan agglomerations in 155 countries classified into 9 world macro-regions. To estimate the unknown parameter(s) of the V–M relation we made use of a simultaneous equation system using both linear (classical TL) and quadratic specifications, with the aim of ascertaining a wide range of simplified (or more complex) association rules between the two dimensions of demographic change. The empirical results show that TL is verified in all nine cases, although a quadratic relationship provides slightly better results than the classical, linear relationship. More specifically, similar estimates for both linear and quadratic relationships were characteristic of ‘new’ demographic continents with more recent and intense urbanization processes (the Americas, and African and Asian countries). The predominance of quadratic relationships characterized regions with long-established urbanization processes, such as Europe, Russia, and, partly, China and the Middle East. The relevance of the TL for a refined understanding of urbanization mechanisms worldwide, and the importance of a quadratic term for distinguishing metropolitan systems that have experienced different development paths, were finally discussed

Tackling Fuel Poverty in London

The challenge of economic and health inequalities caused by fuel poverty are rooted in the rise in fuel costs which have strong implications affecting the cost of living. Fuel costs and rising inflation due to economic and political reasons threaten individuals and families who are already struggling financially, putting them in/at risk of fuel poverty. The UK is one of the first countries to define the challenge of households living in fuel poverty prompting necessary actions, policies and interventions. This study presents the results of an empirical investigation following direct enquires to the Greater London Authority (GLA) and all of London boroughs via Freedom of Information (FOI) requests on retrofit interventions, including an overview of financial incentives and planning assessments with an aim to increase the number of home energy upgrades since April 2021. London adopted its own action plan in 2018 to renew its focus and alleviate more than 350,000 households in fuel poverty (GLA, 2018). The assessment and indicator for fuel poverty has changed over time, from the Low Income High Cost (LIHC) to Low Income Low Energy Efficiency (LILEE) indicator in 2021. However, identifying households in fuel poverty remains challenging and some indicators are somewhat disconnected from what is happening on the ground. The findings suggest that there is a need to establish tools and methodologies that are connected to the national and local context. Fuel poverty is affecting people’s health and well-being, particularly those already facing socio-economic and health inequalities. After the COVID pandemic, a political awareness of fuel poverty is found in the Mayoral manifesto, however the Fuel Poverty Action Plan does not have binding targets and is not regularly updated. Current Fuel Poverty Partnership Tasks are focusing on awareness and communication or the urgent support to households already affected, but not in tackling the root causes of fuel poverty in upgrading fuel poor homes. The uptake on retrofits from 2021 is still low and far from reaching 100k homes and the net zero target in 2030 is approaching fast. The study concludes that while LILEE is decreasing other indicators are increasing with rising energy prices. The London Building Stock Model is not widely used by boroughs, and it only maps the Energy Performance Certificate (EPC) rating which is not sufficient to identify households in fuel poverty. Most schemes such as Energy Companies Obligation (ECO) do not specifically target fuel poverty but have a wider scope of retrofit towards net zero. The Mayor of London should explore a new indicator tool by crossing data from LBSM with socio-economic data to identify fuel poor households more accurately. The indicator could potentially include geographical location, building typology (age, etc), socio-economic / demographics, leading to action plan and retrofit strategies

Wireless capsule endoscopy and proximal small bowel lesions in Crohn's disease

AIM: To investigate the prevalence of proximal small bowel (SB) lesions detected by wireless capsule endoscopy (WCE) in Crohn's disease (CD). METHODS: WCE was performed in 64 patients: 32 with CD of the distal ileum, and 32 controls with iron-deficiency anemia (IDA) or diarrhea. WCE was performed using the Given SB-WCE, followed by small intestine contrast ultrasonography (SICUS). Findings compatible with CD by using WCE included erosions, aphthoid or deep ulcers, and strictures/stenosis. RESULTS: WCE detected proximal SB lesions in 16/32 (50%) patients (14 aphthoid ulcers, 2 deep ulcers, one stricture), which appeared not to be related to clinical parameters [epigastric pain, age, smoking, non-steroidal anti-inflammatory drugs (NSAIDs), IDA]. Among patients with proximal SB lesions, 6 (37%) were smokers, 3 (19%) NSAID users, 3 (19%) had epigastric pain and 4 (25%) had IDA. SICUS detected proximal SB lesions in 3/32 patients (19%) also showing lesions with WCE. No correlations were observed between proximal SB lesions assessed by WCE or by SICUS (χ2 = 1.5, P = 0.2). CONCLUSION: The use of WCE allows the detection of previously unknown upper SB lesions in a high proportion of patients with a previous diagnosis of CD involving the distal ileum. © 2010 Baishideng

Nutritional Screening and Anthropometry in Patients Admitted From the Emergency Department

Background: Due to the high prevalence of malnutrition among hospitalized patients, screening and assessment of nutritional status should be routinely performed upon hospital admission. The main objective of this observational study was to evaluate the prevalence of and the risk for malnutrition, as identified by using three nutritional screening tests, and to observe whether some anthropometric and functional parameters used for nutritional evaluation were related to these test scores. Methods: This single-center observational study included 207 patients admitted from the emergency department for hospitalization in either the internal medicine or surgery units of our institution from September 2017 to December 2018. The prevalence of malnutrition among this patient sample was evaluated by using the Nutritional Risk Screening (NRS-2002), the Subjective Global Assessment (SGA) and the Global Leadership Initiative on Malnutrition (GLIM) criteria. Body mass index (BMI), bioimpedance analysis (BIA), handgrip strength (HGS) and calf circumference (CC) assessments were also performed. Results: According to the NRS-2002, 93% of the patients were at no risk or at low nutritional risk (NRS score < 3), and 7% were at a high nutritional risk (NRS score ≥ 3). On the other hand, according to the SGA, 46.3% of the patients were well-nourished (SGA-a), 49.8% were moderately malnourished (SGA-b), and 3.9% were severely malnourished (SGA-c). Finally, according to the GLIM criteria, 18% patients were malnourished. Body weight, body mass index (BMI), phase angle (PhA), CC and HGS were significantly lower in the patients with NRS scores ≥ 3, SGA-c and in patients with stage 1 and stage 2 malnutrition, according to the GLIM criteria. Conclusion: The NRS-2002, the SGA and the GLIM criteria appear to be valuable tools for the screening and assessment of nutritional status. In particular, the lowest NRS-2002, SGA and GLIM scores were associated with the lowest PhA and CC. Nevertheless, a weekly re-evaluation of patients with better screening and assessment scores is recommended to facilitate early detection of changes in nutritional status

PO-0632: Dose-volume related dysphagia in head and neck cancer Intensity Modulated Radiation Treatment

n/

Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents

Targeted approaches aiming at modulating NHERF1 activity, rather than its overall expression, would be preferred to preserve the normal functions of this versatile protein. We focused our attention on the NHERF1/PDZ1 domain that governs its membrane recruitment/displacement through a transient phosphorylation switch. We herein report the design and synthesis of novel NHERF1 PDZ1 domain inhibitors. These compounds have potential therapeutic value when used in combination with antagonists of β-catenin to augment apoptotic death of colorectal cancer cells refractory to currently available Wnt/β-catenin-targeted agents

Decipher the glioblastoma microenvironment: The first milestone for new groundbreaking therapeutic strategies

Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Despite the combination of novel therapeutical approaches, it remains a deadly malignancy with an abysmal prognosis. GBM is a polymorphic tumour from both molecular and histological points of view. It consists of different malignant cells and various stromal cells, contributing to tumour initiation, progression, and treatment response. GBM’s microenvironment is multifaceted and is made up of soluble factors, extracellular matrix components, tissue-resident cell types (e.g., neurons, astrocytes, endothelial cells, pericytes, and fibroblasts) together with resident (e.g., microglia) or recruited (e.g., bone marrow-derived macrophages) immune cells. These latter constitute the so-called immune microenvironment, accounting for a substantial GBM’s tumour volume. Despite the abundance of immune cells, an intense state of tumour immunosuppression is promoted and developed; this represents the significant challenge for cancer cells’ immune-mediated destruction. Though literature data suggest that distinct GBM’s subtypes harbour differences in their microenvironment, its role in treatment response remains obscure. However, an in-depth investigation of GBM’s microenvironment may lead to novel therapeutic opportunities to improve patients’ outcomes. This review will elucidate the GBM’s microenvironment composition, highlighting the current state of the art in immunotherapy approaches. We will focus on novel strategies of active and passive immunotherapies, including vaccination, gene therapy, checkpoint blockade, and adoptive T-cell therapies

A mouse mammary tumor virus env-like exogenous sequence is strictly related to progression of human sporadic breast carcinoma

A viral etiology of human breast cancer (HBC) has been postulated for decades since the identification of mouse mammary tumor virus (MMTV). The detection of MMTV env-like exogenous sequences (MMTVels) in 30% to 40% of invasive HBCs increased attention to this hypothesis. Looking for MMTVels during cancer progression may contribute to a better understanding of their role in HBC. Herein, we analyzed HBC preinvasive lesions for the presence of MMTVels. Samples were obtained by laser microdissection of FFPE tissues: 20 usual-type ductal hyperplasias, 22 atypical ductal hyperplasias (ADHs), 49 ductal carcinomas in situ (DCISs), 20 infiltrating ductal carcinomas (IDCs), and 26 normal epithelial cells collateral to a DCIS or an IDC. Controls included reductive mammoplastic tissue, thyroid and colon carcinoma, and blood samples from healthy donors. MMTVels were detected by fluorescence-nested PCR. DNA samples from the tissues of nine patients were analyzed by real-time quantitative PCR, revealing a different viral load correlated with stage of progression. Furthermore, as never previously described, the presence of MMTVels was investigated by chromogenic in situ hybridization. MMTVels were found in 19% of normal epithelial cells collateral to a DCIS or an IDC, 27% of ADHs, 82% of DCISs, and 35% of IDCs. No MMTVels were found in the control samples. Quantitative PCR and chromogenic in situ hybridization confirmed these results. These data could contribute to our understanding of the role of MMTVels in HBC. (Am J Pathol 2011, 179:2083-2090; DOI: 10.1016/j.ajpath.2011.06.046