Effect of porosity on PVdF-co-HFP-PMMA-based electrolyte

A novel MPPBEM based on PVdF-co-HFP–PMMA was prepared with a preferential polymer dissolution process. The $N_2$ gas adsorption/desorption and SEM analysis were used to reveal the porous structure of the polymer matrix and attain the maximum pore size in the range of 251 nm. AC-impedance spectroscopy measurement was carried out to investigate the ionic conductivity of MPPBEMs and achieved a maximum ionic conductivity of $10.23 \times 10^{-3} S cm^{-1}$ at room temperature. The lithium transference numbers of MPPBEMs were measured using the DC-polarization method coupled withAC-impedance spectra are found to be above 0.639. Finally, the electrode/electrolyte interfacial resistance was evaluated by monitoring the impedance response at different time intervals

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer

Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules that are found in a wide range of proteins with diverse catalytic and scaffolding functions and are present in most tissues. BRDs selectively recognize and bind to acetylated Lys residues — particularly in histones — and thereby have important roles in the regulation of gene expression. BRD-containing proteins are frequently dysregulated in cancer, they participate in gene fusions that generate diverse, frequently oncogenic proteins, and many cancer-causing mutations have been mapped to the BRDs themselves. Importantly, BRDs can be targeted by small-molecule inhibitors, which has stimulated many translational research projects that seek to attenuate the aberrant functions of BRD-containing proteins in disease