Hubungan Antara Self Efficacy Dengan Kualitas Hidup Pasien Chronic Kidney Disease Yang Menjalani Hemodialisa Di Rumah Sakit Umum Daerah Dr. Moewardi

Penderita gagal ginjal kronis yang menjalani hemodialisa memiliki kualitas hidup yang bervariasi dikarenakan banyak faktor diantaranya adalah Self Efficacy. Penelitian ini bertujuan untuk melihat hubungan antara Self Efficacy dengan kualitas hidup pasien gagal ginjal kronik. Penelitian ini berjenis kuantitatif korelasional dengan menggunakan pendekatan chi square. Populasi yang terdapat dalam penelitian ini yaitu 3995 pasien gagal ginjal kronik yang menjalani hemodialisa di RSUD dr. Moewardi. Hasil penelitian didapat bahwa sebanyak 24 sampel memiliki kualitas hidup baik dengan sisanya buruk, kemudian Self Efficacy didapatkan 20 sampel Self Efficacy rendah dan 22 sampel Self Efficacy tinggi. Berdasarkan chi square didapatkan hasil Rhitung = 0,672 sedangkan tingkat signifikasi didapat 0,001 lebih kecil dari 0,05 sehingga disimpulkan terdapat hubungan antara kedua variabel tersebut. Rhitung menunjukan korelasi tinggi antara kedua variabel. Dapat disimpulkan bahwa Self Efficacy memiliki peranan dalam meningkatkan kualitas hidup pasien gagal ginjal kronik yang menjalani hemodialisa. Peneliti selanjutnya dapat menggunakan faktor lain untuk menentukan pengaruh kualitas hidup

Hubungan Dukungan Keluarga Dengan Kemandirian Lansia Dalam Pemenuhan Aktivitas Sehari-Hari

The decline in health and physical limitations that occur in the elderly will require support from the family in fulfilling daily care. The purpose of this study was to analyze the relationship between family support and the independence of the elderly in fulfilling daily activities. This type of research is a type of quantitative research using a descriptive correlative design and a cross sectional approach. This study uses a non-probability sampling technique with purposive sampling type, the number of samples is 81 respondents in Tangkisan Village, Tawangsari District, Sukoharjo Regency. The results of this study were obtained family support in the village of Tangkisan which was included in the good category, namely 53 respondents (65.4%). And those included in the less category are 28 respondents (34.6%). The results of the independence of the elderly in the fulfillment of daily activities found that the number of elderly in the independent category was 40 people (49.4%) and the elderly with dependent categories were 41 people (50.6%). And the results through the Spearman Rho statistical test obtained the value of p = 0.000 and r = 0.902. Because the value of p (0.000) <α = 0.05, then H0 is rejected and H1 is accepted, meaning that there is a relationship between family support and the independence of the elderly in fulfilling daily activities. The conclusion of this study is that there is a positive and significant relationship between family support and the independence of the elderly in fulfilling daily activities in Tangkisan Village, Tawangsari Community Health Center, Sukoharjo Regency. Suggestions This research can be used as a reference for other researchers who will conduct research in the same field, but it is recommended in further research to increase the number of variables that affect the independence of the elderly

Invertebrate 7SK snRNAs

7SK RNA is a highly abundant noncoding RNA in mammalian cells whose function in transcriptional regulation has only recently been elucidated. Despite its highly conserved sequence throughout vertebrates, all attempts to discover 7SK RNA homologues in invertebrate species have failed so far. Here we report on a combined experimental and computational survey that succeeded in discovering 7SK RNAs in most of the major deuterostome clades and in two protostome phyla: mollusks and annelids. Despite major efforts, no candidates were found in any of the many available ecdysozoan genomes, however. The additional sequence data confirm the evolutionary conservation and hence functional importance of the previously described 3′ and 5′ stem-loop motifs, and provide evidence for a third, structurally well-conserved domain

Immunosenescence and lymphomagenesis

One of the most important determinants of aging-related changes is a complex biological process emerged recently and called \u201cimmunosenescence\u201d. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way. This review presents a brief overview of the interplay between aging, cancer and lymphoma, and the key topic of immunosenescence is addressed in the context of two main lymphoma groups, namely Non Hodgkin Lymphoma (NHL) and Hodgkin Lymphoma (HL). Epstein Barr Virus (EBV) plays a central role in the onset of neoplastic lymphoproliferation associated with immunological changes in aging, although the pathophysiology varies vastly among different disease entities. The interaction between immune dysfunction, immunosenescence and Epstein Barr Virus (EBV) infection appears to differ between NHL and HL, as well as between NHL subtypes

Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.

BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112

Clinical differences between younger and older adults with HIV/AIDS starting antiretroviral therapy in Uganda and Zimbabwe: a secondary analysis of the DART trial

Clinical and immunological data about HIV in older adults from low and middle income countries is scarce. We aimed to describe differences between younger and older adults with HIV starting antiretroviral therapy in two low-income African countries

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe