2 research outputs found
The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility
Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genesβ influence on the attack mechanism of RA, early diagnosis and treatment of RA.Π’ΠΎΠ»Π»-ΠΏΠΎΠ΄ΠΎΠ±Π½ΡΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΡ (TLRs) ΠΈΠ³ΡΠ°ΡΡ Π²Π°ΠΆΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΠΈΠ½Π΄ΡΠΊΡΠΈΠΈ ΠΈ ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ Π²ΡΠΎΠΆΠ΄Π΅Π½Π½ΠΎΠΉ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈΠ»ΠΈ Π°Π΄Π°ΠΏΡΠΈΠ²Π½ΡΡ
ΠΈΠΌΠΌΡΠ½Π½ΡΡ
ΠΎΡΠ²Π΅ΡΠ°Ρ
. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠΎ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈΠ·ΠΌΠ΅Π½ΡΠΈΠ²ΠΎΡΡΡ TLRs ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΡΠ²ΡΠ·Π°Π½Π° Ρ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΡΠΌ Π°ΡΡΡΠΈΡΠΎΠΌ (Π Π). Π¦Π΅Π»ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΠ΄Π½ΠΎΠ½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ΄Π½ΡΠΌ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠΌ Π² ΡΠΈΠ³Π½Π°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°Π½ΡΠ΄ΡΠΊΡΠΈΠΈ TLRs ΠΈ Π³Π΅Π½Π°ΠΌΠΈ ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊ Π Π. G-ΡΠΈΠΏ IL-1RAP rs766442 ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π³Π΅Π½Π°ΠΌΠΈ, ΠΏΡΠ΅Π΄ΠΎΡ
ΡΠ°Π½ΡΡΡΠΈΠΌΠΈ ΠΎΡ Π Π, Π² ΡΠΎ Π²ΡΠ΅ΠΌΡ ΠΊΠ°ΠΊ Π°Π»Π»Π΅Π»ΠΈ T-ΡΠΈΠΏΠ° IL-6R rs11265618 ΠΈ IL-1RAP rs766442 ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π³Π΅Π½Π°ΠΌΠΈ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΊ Π Π. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ Π² ΡΠΈΠ³Π½Π°Π»ΡΠ½ΠΎΠΌ ΠΏΡΡΠΈ TLRs ΠΌΠΎΠΆΠ΅Ρ Π²Π½Π΅ΡΡΠΈ Π²ΠΊΠ»Π°Π΄ Π² Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ°ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ² Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΠΏΡΠΈΡΡΡΠΏΠΎΠ² Π Π, ΡΠ°Π½Π½ΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π Π.The study was supported by Shandong Province young scientist in incentive fund (Grant β 2006BS03018) and National Natural Science Foundation of China (Grant β 30801025)