FORMULATION DEVELOPMENT AND EVALUATION OF NIOSOMAL GEL OF COLLECTIVE ANTI-FUNGAL AGENTS

Objectives: Tea tree oil (TTO) and Eucalyptus oil (EO) are essential oils derived from the leaves and terminal branches of Melaleuca alternifolia and Eucalyptus globulus. Both oils have narrative topical antifungal agents. Niosomal vesicles were chosen for Tea tree and EO dispersion in this investigation because of their ability to protect enclosed drugs, reduce drug dose amount, target drug delivery, increase residence time and penetration. Methods: TTO and EO containing niosomes were made using a modified thin-film hydration process and Carbopol 934 as a gelling agent to produce a smooth antifungal niosomal gel. Results: TTO and EO entrapment efficiency was found to be 84.89±0.19% and 86.86±0.57%, respectively, and percent cumulative drug diffusion of TTO and EO was found to be 84.21% and 85.22% in the prepared optimized batch [N9]. Transmission electron microscopy revealed vesicular, spherical particles in the nano range with a smooth surface. The optimum batch [N9] of niosomal gel was made with 1% w/w carbopol 934. TTO 84.9% and EO 86.89%, respectively, were found to have prolonged drug release in an in vitro release investigation utilizing the dialysis bag method. The G9 batch niosomal gel was found to be stable by performing an accelerated stability study for 3 months. Conclusion: It was concluded that the best formulation batch G9 shows better-sustained release, enhanced residence time, and stability

Dissolution Rate Enhancement of Lansoprazole Tablet in Hydrophilic Carrier Solid Dispersions by Solvent Evaporation Methods

Solid dispersion technique has been developed for improving solubility of water-insoluble drugs, aiming to achieve a better oral bioavailability. The objectives of present investigation is to improve the solubility and rate of dissolution of poorly aqueous soluble drug lansoprazole by preparing solid dispersion with hydrophilic carrier Poly Ethylene Glycol 6000, hydroxy propyl methyl cellulose, Polyvinyl pyrrolidone by using solvent evaporation method and selecting the best solid dispersion. The drug and excipient compatibility study of selected solid dispersion was performed by FTIR and DSC. This study showed no interaction in drug and carrier. The designed granulation method was employed to prepare solid dispersion tablets and the formulation was optimized through investigating the dissolution behaviours. The results indicated PEG and Polyvinyl pyrrolidone in combination of solid dispersion showed the best effect both on physical characterizations and dissolution studies. Furthermore, all type of solid dispersions significantly improved the dissolution rates when compared to pure drug and its corresponding physical mixture (PM). All the evaluations were performed and complies with the pharmacopoeial standards. The formulation F7 showed 98.88% of cumulative drug release within 8 min with zero order release pattern. The solid dispersion tablets prepared in simplified tableting method exhibited better operability, stability and dissolution behaviour than the tablets prepared in traditional ways, which brought more opportunities to solid dispersion technique for industrial productio

Quantum Dots: Method of Preparation and Biological Application

Quantum dots are inorganic semiconductor crystal of nanometer size which having distinctive conductive property depend on its size & shape. After administration of quantum dots parentally they identify target and bound them. Also quantum dots having light emitting property depend on size & shape. Quantum dots are prepared by chemical synthesis method include both organic & water phase synthesis & also by top- bottom approach. Tumor cell targeting & detection of pathogen & toxin are the main application of quantum dots & also in targeting drug delivery system. This review provides the overview of method of preparation of quantum dots & its biological application. Keywords: Quantum dot, targeting drug delivery, biological applicatio

Design and Performance Evaluation of Resource Allocation Mechanisms in Optical Data Center Networks

A datacenter hosts hundreds of thousands of servers and a huge amount of bandwidth is required to accommodate communication between thousands of servers. Several packet switched based datacenter architectures are proposed to cater the high bandwidth requirement using multilayer network topologies, however at the cost of increased network complexity and high power consumption. In recent years, the focus has shifted from packet switching to optical circuit switching to build the data center networks as it can support on demand connectivity and high bit rates with low power consumption. On the other hand, with the advent of Software Defined Networking (SDN) and Network Function Virtualization (NFV), the role of datacenters has become more crucial. It has increased the need of dynamicity and flexibility within a datacenter adding more complexity to datacenter networking. With NFV, service chaining can be achieved in a datacenter where virtualized network functions (VNFs) running on commodity servers in a datacenter are instantiated/terminated dynamically. A datacenter also needs to cater large capacity requirement as service chaining involves steering of large aggregated flows. Use of optical circuit switching in data center networks is quite promising to meet such dynamic and high capacity traffic requirements. In this thesis work, a novel and modular optical data center network (DCN) architecture that uses multi-directional wavelength switches (MD-WSS) is introduced. VNF service chaining use case is considered for evaluation of this DCN and the end-to-end service chaining problem is formulated as three inter-connected sub-problems: multiplexing of VNF service chains, VNFs placement in the datacenter and routing and wavelength assignment. This thesis presents integer linear programming (ILP) formulation and heuristics for solving these problems, and numerically evaluate them.Ett datacenter inrymmer hundratusentals servrar och en stor mängd bandbredd krävs för att skicka data mellan tusentals servrar. Flera datacenter baserade på paketförmedlande arkitekturer föreslås för att tillgodose kravet på hög bandbredd med hjälp av flerskiktsnätverkstopologier, men på bekostnad av ökad komplexitet i nätverken och hög energiförbrukning. Under de senaste åren har fokus skiftat från paketförmedling till optisk kretsomkoppling for att bygga datacenternätverk som kan stödja på-begäran-anslutningar och höga bithastigheter med låg strömförbrukning. Å andra sidan, med tillkomsten av Software Defined Networking (SDN) och nätverksfunktionen Virtualisering (NFV), har betydelsen av datacenter blivit mer avgörande. Det har ökat behovet av dynamik och flexibilitet inom ett datacenter, vilket leder till storre komplexitet i datacenternätverken. Med NFV kan tjänstekedjor åstadkommas i ett datacenter, där virtualiserade nätverksfunktioner (VNFs) som körs på servrar i ett datacenter kan instansieras och avslutas dynamiskt. Ett datacenter måste också tillgodose kravet på stor kapacitet eftersom tjänstekedjan innebär styrning av stora aggregerade flöden. Användningen av optisk kretsomkoppling i datacenternätverk ser ganska lovande ut for att uppfylla sådana trafikkrav dynamik och hög kapacitet. I detta examensarbete, har en ny och modulär optisk datacenternätverksarkitektur (DCN) som använder flerriktningvåglängdsswitchar (MD-WSS) införs. Ett användningsfall av VNF-tjänstekedjor noga övervägd för utvärdering av denna DCN och end-to-end-servicekedjans problem formuleras som tre sammankopplade delproblem: multiplexering av VNF-servicekedjor, VNF placering i datacentret och routing och våglängd uppdrag. Denna avhandling presenterar heltalsprogrammering (ILP) formulering och heuristik för att lösa dessa problem och numeriskt utvärdera dem

FORMULATION DEVELOPMENT AND EVALUATION OF NIOSOMAL GEL OF COLLECTIVE ANTI-FUNGAL AGENTS

Objectives: Tea tree oil (TTO) and Eucalyptus oil (EO) are essential oils derived from the leaves and terminal branches of Melaleuca alternifolia and Eucalyptus globulus. Both oils have narrative topical antifungal agents. Niosomal vesicles were chosen for Tea tree and EO dispersion in this investigation because of their ability to protect enclosed drugs, reduce drug dose amount, target drug delivery, increase residence time and penetration. Methods: TTO and EO containing niosomes were made using a modified thin-film hydration process and Carbopol 934 as a gelling agent to produce a smooth antifungal niosomal gel. Results: TTO and EO entrapment efficiency was found to be 84.89±0.19% and 86.86±0.57%, respectively, and percent cumulative drug diffusion of TTO and EO was found to be 84.21% and 85.22% in the prepared optimized batch [N9]. Transmission electron microscopy revealed vesicular, spherical particles in the nano range with a smooth surface. The optimum batch [N9] of niosomal gel was made with 1% w/w carbopol 934. TTO 84.9% and EO 86.89%, respectively, were found to have prolonged drug release in an in vitro release investigation utilizing the dialysis bag method. The G9 batch niosomal gel was found to be stable by performing an accelerated stability study for 3 months. Conclusion: It was concluded that the best formulation batch G9 shows better-sustained release, enhanced residence time, and stability.</jats:p

Emerg Infect Dis

Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean\uc2\ua01.4, nondiarrheal mean\uc2\ua00.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene

Skirmishing Disconcerting Covid-19 by Drug Reassigning

Background: COVID-19 is a most life threatening condition, therefore it is declared a pandemic by WHO as it has affected the whole world. Even though there are many advanced drug discoveries, viral afflictions are a broad area for researchers. Unfortunately, to date, no drug can treat this lethal infection. COVID -19 has raised the death rate crucially; therefore, it needs the reassigning of drugs for the control of affliction. In some cases, it shows that drug reassigning may cause adverse reactions. But in some countries, these drugs manifest fruitful effects for COVID patients. This article focuses on the effective drug moieties found in in-vitro studies. These drug moieties need further clinical testing based on their in-vitro clinical data. These moieties have shown hope as promising drugs for treating the deadly infection. Objective: The current manuscript is prepared with the main objectives of studying the various drugs and their benefits for the preparation of a vaccine for COVID-19 pandemics and studying the clinical trial status of drugs that are in the final stage of vaccine development. Discussion and Conclusion: The vaccine development process is in progress, and has almost reached the final stage. There are drug reassignments for suppressing the COVID-19 by using various drugs such as Remdesivir, Sarilumab, Favipiravir, Tocilizumab, etc.; the whole world suffered a huge loss due to this pandemic, and the wait for the vaccine will be over shortly. </jats:sec

Most promising solid dispersion technique of oral dispersible tablet

AbstractBackgroundThe most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained.Main textThis review article focuses on the progress in methods of manufacturing and various latest technologies involved in the development of oral disintegrating tablet. The solid dispersion technique is one of the novel techniques to manufacturing the oral dispersible tablet. Solid dispersion is basically a drug polymer two component system.ConclusionThis review article focuses on advantages, disadvantages, materials used as carrier for solid dispersions, methods of preparation of solid dispersion, classification of solid dispersion, promising drugs that can be incorporated into oral disintegrating tablet by solid dispersion techniques, and recent research in solid dispersion technique using polymers as carriers.</jats:sec