Thermal noise in half infinite mirrors with non-uniform loss: a slab of excess loss in a half infinite mirror

We calculate the thermal noise in half-infinite mirrors containing a layer of arbitrary thickness and depth made of excessively lossy material but with the same elastic material properties as the substrate. For the special case of a thin lossy layer on the surface of the mirror, the excess noise scales as the ratio of the coating loss to the substrate loss and as the ratio of the coating thickness to the laser beam spot size. Assuming a silica substrate with a loss function of 3x10-8 the coating loss must be less than 3x10-5 for a 6 cm spot size and a 7 micrometers thick coating to avoid increasing the spectral density of displacement noise by more than 10%. A similar number is obtained for sapphire test masses.Comment: Passed LSC (internal) review. Submitted to Phys. Rev. D. (5/2001) Replacement: Minor typo in Eq. 17 correcte

Assessment of the Potential Impact and Cost-effectiveness of Self-Testing for HIV in Low-Income Countries.

Studies have demonstrated that self-testing for human immunodeficiency virus (HIV) is highly acceptable among individuals and could allow cost savings, compared with provider-delivered HIV testing and counseling (PHTC), although the longer-term population-level effects are uncertain. We evaluated the cost-effectiveness of introducing self-testing in 2015 over a 20-year time frame in a country such as Zimbabwe

Effect of short range order on electronic and magnetic properties of disordered Co based alloys

We here study electronic structure and magnetic properties of disordered CoPd and CoPt alloys using Augmented Space Recursion technique coupled with the tight-binding linearized muffin tin orbital (TB-LMTO) method. Effect of short range ordering present in disordered phase of alloys on electronic and magnetic properties has been discussed. We present results for magnetic moments, Curie temperatures and electronic band energies with varying degrees of short range order for different concentrations of Co and try to understand and compare the magnetic properties and ordering phenomena in these systems.Comment: 15 pages,17 postscript figures,uses own style file

Internal thermal noise in the LIGO test masses : a direct approach

The internal thermal noise in LIGO's test masses is analyzed by a new technique, a direct application of the Fluctuation-Dissipation Theorem to LIGO's readout observable, $x(t)=$(longitudinal position of test-mass face, weighted by laser beam's Gaussian profile). Previous analyses, which relied on a normal-mode decomposition of the test-mass motion, were valid only if the dissipation is uniformally distributed over the test-mass interior, and they converged reliably to a final answer only when the beam size was a non-negligible fraction of the test-mass cross section. This paper's direct analysis, by contrast, can handle inhomogeneous dissipation and arbitrary beam sizes. In the domain of validity of the previous analysis, the two methods give the same answer for $S_x(f)$, the spectral density of thermal noise, to within expected accuracy. The new analysis predicts that thermal noise due to dissipation concentrated in the test mass's front face (e.g. due to mirror coating) scales as $1/r_0^2$, by contrast with homogeneous dissipation, which scales as $1/r_0$ ($r_0$ is the beam radius); so surface dissipation could become significant for small beam sizes.Comment: 6 pages, RevTex, 1 figur

Continuous Avalanche Segregation of Granular Mixtures in Thin Rotating Drums

We study segregation of granular mixtures in the continuous avalanche regime (for frequencies above ~ 1 rpm) in thin rotating drums using a continuum theory for surface flows of grains. The theory predicts profiles in agreement with experiments only when we consider a flux dependent velocity of flowing grains. We find the segregation of species of different size and surface properties, with the smallest and roughest grains being found preferentially at the center of the drum. For a wide difference between the species we find a complete segregation in agreement with experiments. In addition, we predict a transition to a smooth segregation regime - with an power-law decay of the concentrations as a function of radial coordinate - as the size ratio between the grains is decreased towards one.Comment: 4 pages, 4 figures, http://polymer.bu.edu/~hmaks

Evaluating HIV treatment as prevention in the European context

Executive summary The goal of this project is to gather evidence regarding the population-level, and to some extent, individual-level effects of the use of antiretroviral treatment (ART) to prevent HIV infection, and to relate this to current HIV treatment guidelines. To inform the project, formal literature reviews were performed for the three main areas of interest: the effect of antiretroviral therapy in adults on preventing sexual transmission of HIV, prevention of mother-to-child transmission (pMTCT) and post exposure prophylaxis (PEP). The strongest evidence with regard to the effect of treatment of HIV positive individuals to prevent onwards sexual transmission comes from the recent randomised controlled trial (RCT), HPTN052. This study demonstrated that early versus delayed ART led to a 96% relative reduction in onwards linked transmission. Several observational studies of HIV sero-discordant heterosexual couples have also reported that transmission is rare in patients on ART, particularly in those with low HIV-RNA concentrations. However, the findings of HPTN052 and these observational studies are mainly applicable to vaginal heterosexual sex. No direct empirical evidence regarding the relationship between ART use and the risk of HIV transmission through anal intercourse is currently available. Whilst the major HIV treatment guidelines do not explicitly recommend prescribing antiretroviral treatment to prevent onwards transmission, they do not rule out individuals starting ART at a high CD4 count on a case-by-case basis. However, one must also consider the impact of earlier treatment on the HIV positive individual with regard to side effects, and development of drug resistance. Early studies showed that pMTCT regimens containing a single antiretroviral agent (short course zidovudine or single dose nevirapine) or two antiretroviral agents (zidovudine and lamivudine with or without single dose nevirapine) led to clinically important reductions in MTCT rates. However, the most substantial reductions in MTCT rates occurred when combination antiretroviral regimens (more than three antiretroviral drugs) were introduced. These regimens involve the receipt of ART before the third trimester of pregnancy, intrapartum treatment, maternal post-partum treatment and some form of neonatal treatment. There is some evidence from RCTs and extensive evidence from observational studies of the efficacy of these combination regimens, with very low rates of transmission of around 0% to 6%, in settings with no or very little breastfeeding, and 1%-9% when breastfeeding occurs. Furthermore, in settings where avoidance of breastfeeding is not possible, there are a number of studies demonstrating that receipt of maternal and/or neonatal ART during the six months after birth can reduce the risk of perinatal transmissions. All treatment guidelines recommend that HIV-positive pregnant women should receive ART to prevent MTCT, although the exact timing of when ART should begin is not always explicit. Furthermore, where mentioned, use of neonatal ART is also recommended, regardless of whether infants are breastfed. Much of the data supporting the use of PEP are based on animal models, which suggest that PEP is most efficacious if commenced as soon as possible after exposure. When considering occupational exposure to HIV, human studies are limited, as no RCTs exist for ethical reasons. Evidence for efficacy is based on one case control study which demonstrated an 81% reduction in transmission of HIV through the use of zidovudine. Other studies have demonstrated that PEP following occupational exposure is not always effective and there are cases of PEP failure. Similarly, there are also no RCTs assessing the efficacy of PEP for prevention of HIV transmission after sexual exposure, and limited evidence from observational data. Most treatment guidelines agree that PEP is not always effective and PEP policies need to emphasise the importance of risk prevention in the first place in all settings where there is a risk of HIV transmission. Side effects are not uncommon when using PEP, so it is important to consider carefully whether an individual should receive PEP and some studies have suggested that increase in availability of PEP may lead to an increase in risky sex behaviour. Antiretroviral treatment has well documented benefits in reducing transmission of HIV and, in particular, has had a major population level impact on HIV acquisition in children from HIV positive mothers. Further research is needed to help us understand how we can best use ART to prevent HIV infections through other transmission routes, and to develop evidence-based policy recommendations, particularly in the European context

Atividade amilolítica e qualidade fisiológica de sementes armazenadas de milho super doce tratadas com ácido giberélico.

O uso de reguladores de crescimento na fase de germinação melhora o desempenhodas plântulas, acelerando a velocidade de emergência e realçando o potencial das sementes devárias espécies, mesmo sob condições adversas. Este trabalho teve como objetivo avaliar ainfluência do ácido giberélico na atividade amilolítica e no vigor de sementes armazenadas demilho super doce. O experimento foi conduzido nos Laboratórios de Análise de Sementes doDepartamento de Produção Vegetal/FCA e no Laboratório de Bioquímica de Plantas doDepartamento de Química e Bioquímica/IB da Universidade Estadual Paulista (UNESP/Botucatu),entre os meses de julho e setembro de 2001, onde foram feitas as avaliações da qualidade fisiológica,através dos testes de germinação, vigor e bioquímicos. Sementes de milho super doce da cultivarDO-04, foram acondicionadas em sacos de papel e armazenadas por oito meses em câmara seca(40% UR). Após este período, foram colocadas para germinar em rolos de papel toalha, embebidoscom GA3 nas concentrações zero; 50; 100; 150 e 200mg.L-1. Foram avaliadas a germinação, vigore atividade amilolítica das sementes. As sementes submetidas à pré-embebição em solução de50mg.L-1 de ácido giberélico, apresentaram maior germinação e vigor, menor teor de proteínastotais e maior atividade amilolítica

Equal-time two-point correlation functions in Coulomb gauge Yang-Mills theory

We apply a functional perturbative approach to the calculation of the equal-time two-point correlation functions and the potential between static color charges to one-loop order in Coulomb gauge Yang-Mills theory. The functional approach proceeds through a solution of the Schroedinger equation for the vacuum wave functional to order g^2 and derives the equal-time correlation functions from a functional integral representation via new diagrammatic rules. We show that the results coincide with those obtained from the usual Lagrangian functional integral approach, extract the beta function, and determine the anomalous dimensions of the equal-time gluon and ghost two-point functions and the static potential under the assumption of multiplicative renormalizability to all orders.Comment: 33 pages, 7 figures with Feyman diagrams generated with pstricks; revised version with additional references and comments on possible applications added in the conclusions; accepted for publication in Nucl. Phys.

3D Distribution of Molecular Gas in the Barred Milky Way

We present a new model of the three-dimensional distribution of molecular gas in the Milky Way Galaxy, based on CO line data. Our analysis is based on a gas-flow simulation of the inner Galaxy using smoothed-particle hydrodynamics (SPH) using a realistic barred gravitional potential derived from the observed COBE/DIRBE near-IR light distribution. The gas model prescribes the gas orbits much better than a simple circular rotation model and is highly constrained by observations, but it cannot predict local details. In this study, we provide a 3D map of the observed molecular gas distribution using the velocity field from the SPH model. A comparison with studies of the Galactic Center region suggests that the main structures are reproduced but somewhat stretched along the line-of-sight, probably on account of limited resolution of the underlying SPH simulation. The gas model will be publicly available and may prove useful in a number of applications, among them the analysis of diffuse gamma-ray emission as measured with GLAST.Comment: ApJ in pres

Scaling Properties and Wave Interactions in Confined Supersonic Turbulent Bluff-Body Wakes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76227/1/AIAA-19772-438.pd