Synthetic Biology: Mapping the Scientific Landscape

This article uses data from Thomson Reuters Web of Science to map and analyse the scientific landscape for synthetic biology. The article draws on recent advances in data visualisation and analytics with the aim of informing upcoming international policy debates on the governance of synthetic biology by the Subsidiary Body on Scientific, Technical and Technological Advice (SBSTTA) of the United Nations Convention on Biological Diversity. We use mapping techniques to identify how synthetic biology can best be understood and the range of institutions, researchers and funding agencies involved. Debates under the Convention are likely to focus on a possible moratorium on the field release of synthetic organisms, cells or genomes. Based on the empirical evidence we propose that guidance could be provided to funding agencies to respect the letter and spirit of the Convention on Biological Diversity in making research investments. Building on the recommendations of the United States Presidential Commission for the Study of Bioethical Issues we demonstrate that it is possible to promote independent and transparent monitoring of developments in synthetic biology using modern information tools. In particular, public and policy understanding and engagement with synthetic biology can be enhanced through the use of online interactive tools. As a step forward in this process we make existing data on the scientific literature on synthetic biology available in an online interactive workbook so that researchers, policy makers and civil society can explore the data and draw conclusions for themselves

Overview of recent physics results from the National Spherical Torus Experiment (NSTX)

The National Spherical Torus Experiment (NSTX) has made considerable progress in advancing the scientific understanding of high performance long-pulse plasmas needed for future spherical torus (ST) devices and ITER. Plasma durations up to 1.6 s (five current redistribution times) have been achieved at plasma currents of 0.7 MA with non-inductive current fractions above 65% while simultaneously achieving β and β values of 17% and 5.7 (%m T MA ), respectively. A newly available motional Stark effect diagnostic has enabled validation of current-drive sources and improved the understanding of NSTX 'hybrid'-like scenarios. In MHD research, ex-vessel radial field coils have been utilized to infer and correct intrinsic EFs, provide rotation control and actively stabilize the n ≤ 1 resistive wall mode at ITER-relevant low plasma rotation values. In transport and turbulence research, the low aspect ratio and a wide range of achievable β in the NSTX provide unique data for confinement scaling studies, and a new microwave scattering diagnostic is being used to investigate turbulent density fluctuations with wavenumbers extending from ion to electron gyro-scales. In energetic particle research, cyclic neutron rate drops have been associated with the destabilization of multiple large toroidal Alfven eigenmodes (TAEs) analogous to the 'sea-of-TAE' modes predicted for ITER, and three-wave coupling processes have been observed for the first time. In boundary physics research, advanced shape control has enabled studies of the role of magnetic balance in H-mode access and edge localized mode stability. Peak divertor heat flux has been reduced by a factor of 5 using an H-mode-compatible radiative divertor, and lithium conditioning has demonstrated particle pumping and results in improved thermal confinement. Finally, non-solenoidal plasma start-up experiments have achieved plasma currents of 160 kA on closed magnetic flux surfaces utilizing coaxial helicity injection. © 2007 IAEA. T N -

ERBBs in the gastrointestinal tract: Recent progress and new perspectives

The gastrointestinal epithelium does much more than provide a physical barrier between the intestinal lumen and our internal milieu. It is actively engaged in absorption and secretion of salt and water via ion transporters, exchangers and selective ion channels. It is also a continuously self-renewing epithelium that undergoes ordered growth and differentiation along its vertical axis. From this dual perspective, we will consider the actions of the ERBB family of ligands and receptors in the maintenance of gastrointestinal homeostasis and discuss instances when the actions of this family go awry such as in cancer and Ménétrier's disease